ESPE Abstracts (2019) 92 T8

ESPE2019 Poster Presentations Top 20 Poster (20 abstracts)

Bone Mineral Density (BMD) in Women with Turner Syndrome (TS) from the DSD-LIFE Cohort, an Epidemiological Study

Catherine Pienkowski 1,2 , Yasmine El Allali 2 , Audrey Cartault 1,2 , Perrine Ernoult 1 , Solange Grunenwald 1 , Nicole Reish 3 , Hedi Claahsen-Van Der Grinten 4 & Jean-Pierre Salles 2

1Reference Centre of Rare Gynaecology Disease; Paediatric Hospital, University hospital, Toulouse, France. 2Endocrinology, Obesity, Bone diseases, and Medical Gynaecology Paediatric Unit, Children Hospital, University hospital, Toulouse, France. 3Oberärztin, Medizinische Klinik IV, Klinikum der Universität München, Ziemssenstraße 1 80336 München, München, Germany. 4Afdeling kinderendocrinologie, Amalia kinderziekenhuis, Radboud Universiteit Medisch Centrum, Nijmegen, Netherlands

Aim: The objective of the study was to determine bone mineralisation density in Turner syndrome (TS) from DSD life cohort, and to analyse the trabecular (lumbar spine = LS) and cortical bone (femoral neck = FN) mineralisation.

Materials and Methods: This study was part of the DSD-LIFE study, a cross-sectional clinical outcome study of the BMD of TS adult patients from paediatric cohorts. BMD of the LS and FN were expressed in g/cm2 and in women's T scores. Osteoporosis was defined for T score < -2.5 and osteopenia between -1 and -2.5 T score.

Results: In the DSD-LIFE cohort, 113 patients with TS had data of BMD in 4 European countries (Germany n= 34, Netherlands n=41, Poland n=3 and France n=39). History of fracture was found for 8.3% patients. 10.9% of the cohort presented osteoporosis.

Mean age was 30.15 ± 11.1 years. Mean height was 152.4 ± 6.9 cm, mean weight was 59.1 ± 13.6 kg and mean BMI was 25.5 ± 5.6 kg/m2. Mean gynaecological age (GA) (number of years after menarche) was 14.7 ±10 years with a mean age of puberty induction at 14 years ±3 years.

The median for BMD of FN was 0.84g/cm² (IQR 0.75 ; 0.92 g/cm² ) with T score of -0.7 SD ( IQR -1.5 ; -0.2 SD). The median for BMD of LS was 1.0 g/cm² (IQR 0.93 ; 1.09g/cm² ) with T score of -0.6 SD (IQR -1.4 ; -0.1 SD). No difference was noted according to karyotype (45X n=58, and no monosomy n=59). No difference was noted according to induction (n=55) or spontaneous puberty (n=26) and according the hormonal treatment. DMO decrease significantly with age and with GA for the FN (r=-0.2181, P=0.0450) but not for LS. DMO (FN or LS) was not significantly different between the group of woman under 150 cm and the group of woman above 150 cm.

Conclusion: The data of this study report a positive efficiency of estrogenic substitution on bone in TS adult and highlights the need to encourage hormonal treatment compliance for those patients.

Volume 92

58th Annual ESPE

Vienna, Austria
19 Sep 2019 - 21 Sep 2019

European Society for Paediatric Endocrinology 

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