ESPE Abstracts

Introduction: The optimal level of 25-OH-Vitamin D in children is not clear since most studies have been performed on adults. Creating normal levels is problematic since the recommended level of vitamin D is based on the effect of vitamin D on other parameters and not upon its level in the population.

Methods: This is a "big-data" study in which we analyzed Vitamin D tests from 49,935 children sampled in Clalit Health Services, Jerusalem district between 2009 and 2019. The number of samples with associated data were as follows: corrected calcium – 16,333, phosphate – 3174 and PTH - 449. We tested correlations between each parameter and vitamin D.

Results: There was a positive correlation between 25-OH-Vitamin D levels and three different parameters corrected calcium, phosphate and PTH. The level at which further increase in vitamin D did not cause further significant alteration in the corresponding parameter was for calcium and phosphate - at least 100 nmol/l (40 ng/ml), and for PTH there was a significant negative correlation up to 40 nmol/l but the trend continued up to 100 nmol/l.

Conclusion: It appears that the recommended level of 25-OH-D in children should be slightly higher than for adults, in the range of 100 nmol/l.