ESPE Abstracts

Introduction: Children with Small for Gestational Age (SGA) are known to have lower neurocognitive development and an increased in cardiovascular risk in adulthood. 10% of SGA don´t usually do the catch-up and if they meet criteria they have indication to follow Growth Hormone (GH) treatment.

Objectives: To establish the difference between SGA diagnosed children who did or did not catch-up (treated with GH), in terms of: newborn anthropometry (weight at birth (WB) and Length at birth (LB), Final Height (FH) relative to their Target Height (TH): (FH-TH), Body Mass Index (BMI), lipid profile, metabolism of carbohydrate, blood pressure (BP) and academic level valued as studies conducted.

Materials and Methods: Data are collected from a sample of 61 adults born PEG (treated and not treated with GH). Informed consent was obtained by phone, as well as clinical-analytical data that were contrasted with The Clinical History. Those who were premature, multiple parity and those with syndromes were excluded. NOT CACHT-UP GROUP: 30 adults (15 female). Age (mean: 22.8 years); range: 18-30 y. At the birth: WB (sds); mean: -2 sds; range: -3.8- (-0.4); LB (SDS); mean: -2.37 (-0.55 to -4.44). Final height (cm) in female, mean: 153 (r: 148-163.5) and males: 167 (r: 160-170.5). The FH-TH (sds): -0.57 (r: -2.05-1). The actual BMI is 19.8 (r: 15.2-25). Only a patient has overweight. The 48.4% have University studies. CACHT-UP GROUP: 31 adults (15 female). Age (mean: 27.5 years); range: 23-32 y. At the birth: WB (sds); mean: -3 sds; range: -4.5- (--1.6); LB (SDS); mean: -3.2 (r: -4.7 to -1.99). Final height (cm) in female, mean: 160.8 (r: 152-174) and males: 169.7 (r: 160-189.0). The FH-TH (sds): -0.31 (r: -2.7-1.54). The actual BMI is 23.6 (r: 17.2-31.1).Three adults have obesity and six have overweight. The 25% have abnormal lipid profile or abnormal BP. The 38% have University studies. Anthropometric data at birth are significate smaller in catch-up group (P < 0.001). The mean final height is significate higher in Catch-up group (P < 0.001). No difference in FH-TH. The BMI is significate higher in Catch-up group (p: 0.001).

Conclusions: - Anthropometry at birth is lower in those who recovered size, but the final size is larger. - Both groups reach similar academic levels - There are no differences between the two groups in FH-TH. - BMI is higher in those who did catch-up and they presents more cardiovascular risk.