Previous issue | Volume 94 | ESPE2021

59th Annual ESPE (ESPE 2021 Online)

Online,
22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

ePoster Category 2

Fat, metabolism and obesity

hrp0094p2-171 | Fat, metabolism and obesity | ESPE2021

Association of calprotectin with obesity in prepubertal children

Yoon Jong Seo , Young Kim Eun , Hee Yi Kyung , Suk Shim Young , Hwang IL Tae ,

Background: Perturbation of inflammation is critically linked to nutrient metabolic pathways and obesity-associated complications, such as insulin resistance and type 2 diabetes (T2DM). The S100 family of proteins, including S100A8/A9 (calprotectin), have been implicated in disease pathogenesis and investigated as potential markers of inflammation. In adults, increased circulating levels of calprotectin have been reported in obesity-related chronic low-grade i...

hrp0094p2-172 | Fat, metabolism and obesity | ESPE2021

Metabolic syndrome and birth anthropometric data in Prader-Willi syndrome.

Salvatoni Alessandro , Agosti Massimo , Azzolini Sara , Bonaita Valentina , Crino Antonino , Delvecchio Maurizio , Augusta Greggio Nella , Iughetti Lorenzo , Madeo Simona F , Nosetti Luana , Osimani Sara , Paino Roberta , Rutigliano Irene , Sacco Michele , Salvatore Silvia , Sartorio Alessandro , Grugni Graziano ,

Introduction: Previous studies showed that non-obese children and adults with Prader-Willi syndrome (PWS) have a low frequency of metabolic syndrome (MetS), while obese ones have a frequency similar to that of non-PWS obese. It is known that individuals born small for gestational age (SGA) have a greater predisposition to the development of MetS. Recent neonatal percentiles of subjects with PWS (Salvatoni et al, Am J Med Genet Part A, 2019) documented...

hrp0094p2-173 | Fat, metabolism and obesity | ESPE2021

Evaluation of the BigO system during the COVID-19 outbreak in Greece

Kassari Penio , Tragomalou Athanasia , Vourdoumpa Aikaterini , Koutaki Diamanto , Papadopoulou Marina , Manou Maria , Ioakeimidis Ioannis , Filis Konstantinos , Theodoropoulou Eleni , Lymperopoulos Giorgos , Ferri Daniel , Karavidopoulou Youla , Stefanopoulos Leandros , Diou Christos , Lekka Eirini , Maglaveras Nicos , Delopoulos Anastasios , Charmandari Evangelia ,

Background: Since December 2019, the world has witnessed a global pandemic due to SARS-CoV-2 coronavirus (COVID-19), which has led to lifestyle changes as a result of Public Health Regulations and Guidelines introduced by governments worldwide.Objective: To determine the body mass index (BMI) trajectory in children and adolescents with overweight and obesity with respect to the COVID-19 outbreak in Greece.<p class="a...

hrp0094p2-174 | Fat, metabolism and obesity | ESPE2021

The relationship between sleep time and obesity in childhood

Zeynep Altun Ekin , Bilir Pelin , Ergur Ayca Torel ,

Childhood obesity (CO) is an important risk factor for the development of many chronic metabolic diseases in adulthood. Sleep patterns are known to affect leptin and ghrelin levels in the body. Recent studies using Functional Magnetic Resonance Imaging (fMRI) have shown that insufficient sleep time leads to unhealthy eating behaviors in the brain. The aim of this study is to investigate the association between sleep time in childhood and obesity. Consistent with this associati...

hrp0094p2-175 | Fat, metabolism and obesity | ESPE2021

The relationship between acanthosis nigricans and vitamin D in obese children and adolescents

Zeynep Altun Ekin , Ergur Ayca Torel , Bilir Pelin ,

Studies show that vitamin D deficiency can have negative effects on glucose homeostasis, although the mechanism for this is still unclear. The possible mechanism may be related to the presence of vitamin D receptors and their metabolizing enzymes in insulin-sensitive cell types, such as pancreatic cells and adipocytes. The aim of this study is to compare how serum 25- OH D level and HOMA-IR index are related to acanthosis nigricans (AN) and which of them is a better marker for...

hrp0094p2-176 | Fat, metabolism and obesity | ESPE2021

Exploring Urinary Bile Acids as Potential Markers of Metabolism: Reference Values in Children by Targeted LC-MS/MS

Schauermann Marcel , Wang Rong , Hartmann Michaela F. , Remer Thomas , Hua Yifan , Shmoish Michael , Bereket Abdullah , Wasniewska Malgorzata , Hochberg Ze’ev , Gawlik Aneta , Wudy Stefan A. ,

Bile acids (BA) are C24 steroids synthesized from cholesterol in liver. Originally, they were mainly considered to function as emulsifiers supporting resorption of lipophilic food compounds and excretion of metabolic products. Recently, their additional biological and endocrine functions in the regulation of metabolism have aroused interest of researchers. In contrast to BA in blood, it is surprising that hardly any data exist on BA in the most accessible human biof...

hrp0094p2-177 | Fat, metabolism and obesity | ESPE2021

A novel mitochondrial tRNAThr 15894G>A mutation is potentially risk factor in a Chinese family with obesity

Wang Jinling , Ji Yanchun , Fu Junfen ,

A Chinese family of Han with symptoms of matrilineally-inherited obesity was assessed and its clinical, genetic, and molecular profiling was conducted. Obesity was observed in matrilineal relatives (3 out of 14) of a single generation (of 3 alive generations) of this family. On pedigree analysis and sequencing of their mitochondrial DNA, a novel homoplasmic mutation of the mitochondrial tRNAThr gene (15894G>A) was identified in these individuals. This mutation c...

hrp0094p2-178 | Fat, metabolism and obesity | ESPE2021

Obesity is potentially associated with a novel mitochondrial tRNAGly 10029A>G mutation in a Chinese family

Wang Jinling , Ji Yanchun , Fu Junfen

In this study, we conducted a clinical, genetic, and molecular profiling of a Han Chinese family with evident of matrilineally-inherited obesity. Obesity was evident in 2/6 matrilineal relatives in a single generation of this family (of 3 available generations). When the mitochondrial DNA of these individuals was sequences and a pedigree analysis was performed, we were able to identify a novel homoplasmic mutation of the mitochondrial tRNAGly gene (10029A>G) in t...

hrp0094p2-179 | Fat, metabolism and obesity | ESPE2021

Frequency of MC4R Pathway Variants in a Large US Cohort of Pediatric and Adult Patients with Severe Obesity

Bend Eric , Antao Tiago , Ichetovkin Ilia , Norton Rick , Garfield Alastair , Moeller Ida ,

Background: The melanocortin-4 receptor (MC4R) pathway is critical for the regulation of energy balance. Variants in a number of genes within this pathway have well-established associations with severe obesity. However, the overall frequency of rare variants in these genes has not been assessed systematically in a clinically relevant population, and it is unknown whether variant frequency differs depending on the age of ascertainment. Genetic testing can impro...

hrp0094p2-180 | Fat, metabolism and obesity | ESPE2021

Impact of the COVID-19 pandemic and related lockdown measures on lifestyle behaviours and quality of life in children and adolescents with severe obesity

Welling MS , Abawi O , van den Eynde E , van Rossum EFC , Halberstadt J , Brandsma AE , Kleinendorst L , van den Akker ELT , van der Voorn B ,

Introduction: Lockdown measures following the COVID-19 pandemic are shown to have greatly affected lifestyle behaviours and health-related quality of life (HRQoL) of children. The impact on children with severe obesity has not yet been described. Aim of this study was to investigate the impact of COVID-19 lockdown on eating behaviours, physical activity (PA), screen time, and HRQoL of children (including adolescents) with severe obesity....

hrp0094p2-181 | Fat, metabolism and obesity | ESPE2021

Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children

Carreras-Badosa Gemma , Gomez-Vilarrubla Ariadna , Mas-Pares Berta , Puerto-Carranza Elsa , Diaz-Roldan Ferran , Riera-Perez Elena , de Zegher Francis , Ibanez Lourdes , Bassols Judit , Lopez-Bermejo Abel ,

Introduction: Both the innate and adaptive immune responses are deregulated in individuals with obesity and are a key driver of its associated metabolic alterations. Although the anti-inflammatory growth differentiation factor 15 (GDF-15) is a candidate protein against obesity, its mechanisms regulating the immune responses are not fully understood.Methods: We examined whether serum GDF-15 was related to serum levels of ...

hrp0094p2-182 | Fat, metabolism and obesity | ESPE2021

Describing the Natural History of Clinical, Biochemical and Radiological outcomes of children with Familial Partial Lipodystrophy type 2 (FPLD2) attending a National Service for Severe Insulin Resistance: a Retrospective Cohort Study

Xuan Zhong Zhu , Stears Anna , Harris Julie , Wilber Ellen , Savage David , O’Rahilly Stephen , Williams Rachel ,

Background: FPLD2 results from autosomal dominant mutations in the LMNA gene. The physical appearance develops through adolescence where subcutaneous fat deposits of the limbs, trunk, buttocks and legs do not develop resulting in a muscular appearance. The metabolic phenotype includes elevations in triglyceride concentrations and hepatosteatosis with resultant insulin resistance. Co-morbidities that may manifest during young adulthood include early-onset diabe...

hrp0094p2-183 | Fat, metabolism and obesity | ESPE2021

Evaluation of the BigO system in a clinical setting in Greece

Kassari Penio , Tragomalou Athanasia , Vourdoumpa Aikaterini , Koutaki Diamanto , Papadopoulou Marina , Manou Maria , Ioakeimidis Ioannis , Filis Konstantinos , Theodoropoulou Eleni , Lymperopoulos Giorgos , Ferri Daniel , Karavidopoulou Youla , Stefanopoulos Leandros , Diou Christos , Lekka Eirini , Maglaveras Nicos , Delopoulos Anastasios , Charmandari Evangelia ,

Background: Obesity in childhood and adolescence represents one of the most important public health problems. Over the last decade, the widespread use of personal digital technologies, such as smart mobiles and accelerometers, create new possibilities for collecting bevavioral data objectively.Objective: To evaluate the body mass index (BMI) trajectory after at least one month’s use of the BigO system.<p class="...

hrp0094p2-184 | Fat, metabolism and obesity | ESPE2021

Assessment of DRD2 dopamine receptor gene rs6277 in pediatric obesity: a case-control study

Machado Pinto Renata , Alves Nygell S , Fortes Jakeline S , Monteiro Rubia V , Minasi Lysa B , da Cruz Aparecido Divino ,

Introduction: Obesity is a multifactorial disease resulting from an interplay between genetics and the environment. Metabolic, nutritional, psychosocial, and lifestyle factors participate, promoting various degrees of overweight or obesity. Pediatric obesity increases after infancy and is higher in early adulthood, showing a heritability of up to 85%. Genetic variants associated with BMI in children can exert their effects by affecting eating behavior, as is t...

hrp0094p2-185 | Fat, metabolism and obesity | ESPE2021

A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program is Associated with Increased Leukocyte Telomere Length in Children and Adolescents with Overweight and Obesity

Paltoglou George , Raftopoulou Christina , Nicolaidis Nicolas , Genitsaridi Sophia , Karabatsou Sophia , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia ,

Background/Aim: Leucocyte telomere length (LTL) is a robust marker of biological aging and is associated with obesity and cardiometabolic risk factors even in childhood and adolescence. The aim of the present study was to assess the effect of a structured, comprehensive, multidisciplinary, personalized, lifestyle intervention program of healthy diet and physical exercise on LTL in children and adolescents with overweight and obese.Materi...

hrp0094p2-186 | Fat, metabolism and obesity | ESPE2021

Diagnostic accuracy of Tri-Ponderal mass index (kg/m3) for identifying glucose intolerance in obese children and adolescents.

Arciniegas Larry , Mogas Eduard , Tomasini Rosangela , Fabregas Ana , Clemente Maria , Yeste Diego ,

Introduction: The identification of obese patients with increased susceptibility and risk for glucose intolerance and type 2 diabetes requires an oral glucose tolerance test (OGTT). Reference values for Body mass index (BMI) and Tri-Ponderal mass index (TMI) according to age and sex of healthy children in Spain without malnutrition or obesity have recently been published (*). TMI values remain very uniform in both boys and girls from the age of 8 to 18 years, ...

hrp0094p2-187 | Fat, metabolism and obesity | ESPE2021

Effect of Semaglutide on body weight in obese children with craniopharyngioma: a preliminary report

Jourdren Marie , Coutant Regis , Bouhours Nouet Natacha , Amsellem Jager Jessica , Donzeau Aurelie , Levaillant Lucie , Delion Mathieu ,

Background: Pituitary insufficiency and severe obesity are common sequelae of craniopharyngioma and its treatment. Once weekly glucagon-like Peptide 1 (GLP1) analog’s semaglutide has recently shown efficacy in adults with common obesity.Objective: We evaluated the efficacy and safety of Semaglutide, a once-weekly GLP-1 analog, in 6 children with craniopharyngioma and morbid obesity.Subjects an...

hrp0094p2-188 | Fat, metabolism and obesity | ESPE2021

Development of a predictive normogram to assess the risk of liver steatosis in childhood obesity

Martos-Moreno Gabriel A. , Maria Andres-Esteban Eva , Martinez-Villanueva Julian , Sirvent Sara , Hawkins Federico G. , Argente Jesus ,

Background: Liver steatosis (LS) results from ectopic fat deposition and can be present in obesity even at early ages. Similar to insulin resistance, the onset of LS does not seem to depend exclusively upon the severity of obesity and shows a large interindividual variability.Objective: Our objective was to develop a predictive normogram for LS in children and adolescents with obesity ba...

hrp0094p2-189 | Fat, metabolism and obesity | ESPE2021

Prospective evaluation of liver stiffness in obese children: the role of shear wave elastography.

Corica Domenico , Bottari Antonio , Aversa Tommaso , Anna Morabito Letteria , Curatola Selenia , Alibrandi Angela , Ascenti Giorgio , Wasniewska Malgorzata ,

Objectives: The increased incidence of childhood obesity and related non-alcoholic fatty liver disease (NAFLD) has determined the need to identify a non-invasive technique to diagnose and monitor NAFLD. Two-dimensional shear wave elastography (2D-SWE) has emerged as a reliable, non-invasive, tool to evaluate liver tissue elasticity in clinical practice. Aims of this study were to longitudinally evaluate 2D-SWE changes in relation to weight loss, metabolic prof...

hrp0094p2-190 | Fat, metabolism and obesity | ESPE2021

Evaluation of the nutritional behavior of small and large for gestational age children

Prylutskaya Veranika , Solntsava Anzhalika , Dashkevich Helena , Sukalo Alexander , Shyshko Julia ,

Background: In recent years a special interest of researchers is focused on questions related to the early stages of the formation of food behavior (FB), considering their close connection with socially significant problems of the present - obesity, metabolic syndrome, cardiovascular pathology, etc.Aims: To assess the characteristics of the children’ nutritional behavior, taking into account the level of physical development at birt...

hrp0094p2-191 | Fat, metabolism and obesity | ESPE2021

Resting energy expenditure and body composition in children and adolescents with severe obesity due to (suspected) medical causes: comparison between different subtypes of obesity

Abawi Ozair , Koster Emma , Welling Mila , Boeters Sanne , van Rossum Elisabeth , van der Voorn Bibian , de Groot Cornelis , van den Akker Erica ,

Background: Paediatric obesity is a multifactorial disease characterized by an imbalance between energy intake and expenditure. In rare cases, obesity is caused by underlying medical disorders arising from disruptions in the leptin-melanocortin pathway, which regulates satiety and energy expenditure.Aim: To investigate resting energy expenditure (REE) in relation to body composition in children and adolescents with sever...

hrp0094p2-192 | Fat, metabolism and obesity | ESPE2021

Exercise-induced expression of myokines in adolescents with simple obesity.

Kasyanova Yulia , Vasyukova Olga , Okorokov Pavel , Bezlepkina Olga , Peterkova Valentina , Malysheva Natalya ,

Myokines - biologically active proteins produces and secretes by skeletal muscles in response to physical activity (PA). They play a role in lipid and glucose metabolism, myogenesis and osteogenesis, thermogenesis activity. Exercise-induced expression of myokines in adolescents with simple obesity insufficiently studied.Objective: to determine which intensity and duration of PA maximally changes the level of myokines (interleukin-6 (IL-6...

hrp0094p2-193 | Fat, metabolism and obesity | ESPE2021

Early decline in Sertoli cell function during puberty in overweight and obese boys: a cross-sectional study

Rerat Solene , Amsellem-Jager Jessica , L’hours Marie-Clemence , Bouhours-Nouet Natacha , Donzeau Aurelie , Rouleau Stephanie , Levaillant Lucie , Emeriau Fabienne , Moal Valerie , Boux de Casson Florence , Lahlou Najiba , Coutant Regis ,

Context: Alterations in semen characteristics and Sertoli and Leydig cell function have been described in obese male adults. Whether these alterations occur before adulthood has not been fully evaluated.Objective and Design: Cross sectional study from 2010 to 2018 describing gonadic function in overweight-obese (ow/ob) boys through childhood and adolescence.Setting: Monocentric study in the Pediatric Endocrinology ...

hrp0094p2-194 | Fat, metabolism and obesity | ESPE2021

Vitamin D deficiency in obese children

Mikhno Hanna , Solntsava Anzhalika ,

Objective: determination of changes in metabolic status and vitamin D concentrations in obese children.Methods: We examined 221 children in the University Hospital (Minsk) from 2019 to 2021 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) - 159...

hrp0094p2-195 | Fat, metabolism and obesity | ESPE2021

Assessment of Hyperphagia in Patients with Monogenic Obesity

Zorn Stefanie , von Schnurbein Julia , Schirmer Melanie , Kohlsdorf Katja , Brandt Stephanie , Wabitsch Martin ,

Introduction: Besides an excessive, early-childhood weight gain, hyperphagia is the key symptom in patients with monogenic obesity. However, the assessment of hyperphagia is still challenging. Here, we applied the hyperphagia questionnaire developed for patients with Prader-Willi-Syndrome (PWS) to assess the severity of hyperphagia in patients with monogenic obesity.Methods: Pediatric patients with biallelic pathogenic l...

hrp0094p2-196 | Fat, metabolism and obesity | ESPE2021

Machine Learning Quest for Predictive Markers of Lifestyle Modification Outcomes in Pediatric Obesity Treatment

Gawlik Aneta , Shmoish Michael , Bereket Abdullah , Wasniewska Malgorzata , Antosz Aleksandra , Kırkgoz Tarık , Turan Serap , Guran Tulay , Aversa Tommaso , Corica Domenico , Wudy Stefan A. , Hartmann Michaela F. , Gruszczynska Katarzyna , Hochberg Ze’ev ,

Context: The traditional approach to childhood obesity management is lifestyle modification/LSM. Nevertheless, the response rate is variable and difficult to predict.Aim: A systematic search for markers to predict outcomes of simple LSM in pediatric obesity management.Patients/Methods: Out of 240 children with obesity (BMI>97%), recruited to a prospective ‘multi-OMICS’ study granted b...

hrp0094p2-197 | Fat, metabolism and obesity | ESPE2021

Triponderal mass index for the categorisation of childhood obesity on the basis of 58.364 observations of 7.792 patients

Corripio Raquel , Alder Lorna , Perez Jacobo , Sanchez-Garvin Dunia , Rivera Josefa ,

Introduction: childhood obesity constitutes a relevant problem of public health. Body mass index (BMI) is the most used anthropometric parameter for its definition: >2 z-score deviation (SD) according to age and sex for reference charts. Recent studies have proposed triponderal mass index (TMI) to identify metabolic risk by obesity. TMI presents the advantage to be a constant value simplifying the calculations.Aims: determine the use...

hrp0094p2-198 | Fat, metabolism and obesity | ESPE2021

Successful weight loss and resolution of hepatic fibrosis in a girl with severe obesity

Apperley Louise , Erlandson-Parry Karen , Clarke Ellie , Gait Lucy , Auth Marcus , Senniappan Senthil ,

Introduction: Childhood obesity is continuing to increase worldwide resulting in a rise in the number of individuals with complications secondary to obesity. Non-alcoholic fatty liver disease (NAFLD) is seen in both adult and paediatric populations and if not treated appropriately is potentially life-threatening, as it may progress to advanced fibrosis, cirrhosis or hepatocellular carcinoma. NAFLD has now become the most common indication for liver transplant ...

hrp0094p2-199 | Fat, metabolism and obesity | ESPE2021

Association of Thyroid-Stimulating Hormone and Free Thyroxine Concentrations with Cardiometabolic Risk Factors in Euthyroid Obese Children and Adolescents with Metabolic Syndrome

Binou Maria , Tragomalou Athanasia , Manou Maria , Tragomalou Nansy ,

Background: Obesity in childhood and adolescence represents a major public health problem of our century and the leading cause of premature cardiovascular disease (CVD). A moderate elevation of thyroid-stimulating hormone (TSH) concentrations is frequently observed in obese children.Aim: The aim of our study was to evaluate the association of TSH and free thyroxine (FT4) concentrations with the clustering of cardiometabo...

hrp0094p2-200 | Fat, metabolism and obesity | ESPE2021

Impact of weight loss on gonadic function in overweight and obese boys

Rerat Solene , Coutant Regis , Beaumesnil Marion , L’hours Marie-clemence , Bouhours-Nouet Natacha , Donzeau Aurelie , Rouleau Stephanie , Levaillant Lucie , Emeriau Fabienne , Moal Valerie , Boux de casson Florence , Amsellem-Jager Jessica ,

Introduction: In obese boys, alteration of Sertoli and Leydig cell functions have been described, but potential reversibility of these alterations after weight loss during childhood has not been fully evaluated.Objective: Evaluate the impact of weight loss on gonadic function in obese boys.Setting: Monocentric study in the Pediatric Endocrinology Unit of Angers University Hospital ant its follow-up...

hrp0094p2-201 | Fat, metabolism and obesity | ESPE2021

Weight status and body composition of children and adolescents during the COVID-19 pandemic

Brener Avivit , Azoulay Erez , Yackobovitch-Gavan Michal , Lopez Adar , Sheppes Tamar , Yaacov Hadar , Gilboa Inbar , Waksman Yarden , Lebenthal Yael ,

Background: The COVID-19 pandemic has tremendous effects on lifestyle that could potentially cause health-related problems. Therefore, extreme preventive measures were taken, including the closure of schools and after school activities. This dramatic alteration in daily routine could lead to adverse consequence of increasing obesity. In this study we aimed to investigate the change in weight status and body composition parameters of children and adolescents du...

hrp0094p2-202 | Fat, metabolism and obesity | ESPE2021

The challenges faced in the management of Congenital Generalized Lipodystrophy.

Abdelmeguid Yasmine , Elashry Reham , Elsayed Shaymaa , Raafat Shaymaa ,

Background: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease. The prevalence has been reported to be 1 in 10million with around 500 cases worldwide. The absence of functional adipocytes results in storage of lipids in other tissues, including muscle & liver. The diagnosis of CGL is based on clinical data; however, there is phenotypic heterogeneity. Metreleptin injections cause decreased appetite & is beneficial in loweri...

hrp0094p2-203 | Fat, metabolism and obesity | ESPE2021

Anthropometric and clinical situation in two groups of young adults born Small for Gestational Age (a group with catch-up and another without catch-up and treated with Growth Hormone)

Vela Amaya , Gonzalez Maria Regina , Diaz Cristina , Elorza Amaia , Grau Gema , Rodriguez Amaya , Rica Itxaso ,

Introduction: Children with Small for Gestational Age (SGA) are known to have lower neurocognitive development and an increased in cardiovascular risk in adulthood. 10% of SGA don´t usually do the catch-up and if they meet criteria they have indication to follow Growth Hormone (GH) treatment.Objectives: To establish the difference between SGA diagnosed children who did or did not catch-up (treated with GH), in terms...

hrp0094p2-204 | Fat, metabolism and obesity | ESPE2021

Changes in objectively measured physical activity after 2-year lifestyle intervention in pediatric patients with abdominal obesity

Ojeda-Rodriguez Ana , Morell-Azanza Lydia , Luis Leon Jose , Macias Maria , Chueca Maria , Marti Amelia , Cristina Azcona-Sanjulian Maria ,

Introduction: it has been widely demonstrated that high physical activity (PA) levels prevent obesity development. The practice of moderate, regular PA reduces abdominal obesity, hypertension, insulin resistance, dyslipidemia and improves risk factors for obesity-related comorbidities (e.g. diabetes or cardiovascular diseases) independently of weight loss. However, in the childhood population, where sedentary behavior has increased in recent decades, few studi...

hrp0094p2-205 | Fat, metabolism and obesity | ESPE2021

Assessment of cardiometabolic risk factor clustering in obese children and adolescents with metabolic syndrome

Tragomalou Athanasia , Manou Maria , Loukopoulou Sofia , Binou Maria , Papadopoulou Marina , Kassari Penio , Charmandari Evangelia ,

Background: Obesity in childhood and adolescence has reached epidemic proportions. Endothelial dysfunction, as a consequence of dyslipidemia, hypertension, insulin resistance and inflammation, imposes a substantial risk for the development of metabolic syndrome (MS) in childhood and compromises the health of the pediatric population by promoting premature development of atherosclerotic cardiovascular disease.Aim: To inve...

hrp0094p2-206 | Fat, metabolism and obesity | ESPE2021

HOMA-IR in obese children with BMI ≥2.5SDS, but not <2.5SDS, differ significantly from normal weight children

Leka-Emiri Sofia , Dikou Maria , Evangelopoulou Catherine , Kafetzi Maria , Petrou Vasilios , Vlachopapadopoulou Elpis , Michalacos Stefanos ,

Objective: Compare HOMA-IR between obese and normal weight children.Methods: 292 children (156 females), BMI (≥0SD), Tanner stage 1/>2: 163/129, divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) were analyzed retrospectively from the medical records. Age, sex, fasting blood glucose and insulin as well as the ho...

hrp0094p2-207 | Fat, metabolism and obesity | ESPE2021

Restriction of physical activity is the main cause of childhood obesity during the COVID-19 pandemic – reflections from a study conducted in 3 clinical centers in southern Poland

Zachurzok Agnieszka , Wojcik Małgorzata , Gawlik Aneta , Starzyk Jerzy B. , Mazur Artur ,

Background: The aim of this study was to analyze the impact of the COVID-19 pandemic lockdown on behaviors and subsequent changes in BMI in children from southern Poland.Methods: The study included 206 participants (104 females and 102 males) with a complete analysis of 177 (96 females and 81 males) with a mean age of 12.8 ± 2.6 years admitted to three pediatric endocrinology clinics (Rzeszów, Kraków, and ...

hrp0094p2-208 | Fat, metabolism and obesity | ESPE2021

OSAS in childhood obesity is a more frequent and earlier complication than expected

Deiana Giuseppina , Maltoni Giulio , Zucchini Stefano , Gallucci Marcella , Levi della Vida Francesca , Barberi Carolina , Pession Andrea , Cassio Alessandra ,

Introduction: Childhood obesity is associated with several complications, involving many systems. The prevalence of respiratory problems, such as obstructive sleep apnea syndrome (OSAS), is higher in obese children and adolescents. In fact, OSAS affects 13–59% of obese children and the severity is strongly associated with weight excess. Although overnight pulse oximetry (PO) can be used for diagnosing OSAS, a complete night polysomnography (PSG), which re...

hrp0094p2-209 | Fat, metabolism and obesity | ESPE2021

A novel homozygous variant of the leptin receptor (LEPR) gene causing familiar early-onset severe obesity in two siblings

Molinari Silvia , Ceccarini Giovanni , Masera Nicoletta , Spano Alice , Maitz Silvia , Fossati Chiara , Lazzerotti Alessandra , Santini Ferruccio , Cattoni Alessandro ,

Introduction: The leptin-melanocortin pathway is a well-studied pivotal player of body weight regulation and energy homeostasis. Pathogenic mutations of the genes involved in this pathway may result in early-onset severe obesity (ESO).Case Report: We hereby report the case of a 14-year-old girl who was referred to our pediatric outpatient clinic for the evaluation of ESO. Her parents were non-obese first cousins born in Morocco. At the t...

hrp0094p2-210 | Fat, metabolism and obesity | ESPE2021

Sleep quality and metabolic syndrome in pediatric patients with abdominal obesity

Catalan Ana , Ana Ojeda-Rodriguez , Gea Alfredo , Macias Maria , Chueca Maria , Berrade Sara , Marti Amelia , Azcona-Sanjulian Maria Cristina ,

Aim: to evaluate sleep quality by accelerometry and its association with anthropometry and biochemical parameters in children and adolescents after a multidisciplinary interventionSubjects Materials and Methods: One hundred and twenty-two children and adolescents with abdominal obesity, aged 7 to 16 years, were included in a multidisciplinary intervention study to lose weight. Abdominal obesity was diagnosed using the waist circumference...

hrp0094p2-211 | Fat, metabolism and obesity | ESPE2021

The lockdown effects on a pediatric obese population in the COVID-19 era

D’Amico Federica , Cucinotta Ugo , Lugara Cecilia , Zirilli Giuseppina , Zema Attilio , Lonia Paolina , Wasniewska Malgorzata , Valenzise Mariella ,

Background: The social consequences of COVID-19 pandemic are universally known. In particular, the pediatric population is dealing with a radical lifestyle change. For some risk categories, such as overweight and obese children, the impact of home confinement has been greater than for others. Not only have the increased sedentary life, the wrong diet and social distancing stopped the chance of losing weight, but also worsened the general life conditions.<p...

hrp0094p2-212 | Fat, metabolism and obesity | ESPE2021

The Relationship between Acanthosis Nigricans and Vitamin D Levels in Obese Children

Daye Munise , Selver Eklioglu Beray , Atabek Mehmet Emre ,

Aim: Acanthosis nigricans (AN) is the most important skin complication of obesity. In our study, the relationship of acanthosis nigricans and vitamin D levels was evaluated in children.Methods: Obese children aged between 6 and 18 years old, who were examined in the pediatric endocrinology outpatient clinic, were included. The patients’ anthropometric measurements and laboratory results and vitamin D levels were rec...

hrp0094p2-213 | Fat, metabolism and obesity | ESPE2021

Influence of birth weight on cardiovascular risk factors in obese children and adolescents

Paraluppi Valentina , Casano Simona , Guzzetti Chiara , Ibba Anastasia , Murianni Agnese , Gallo Manuela , Casula Letizia , Loche Sandro ,

Background: Birth weight (BW) is associated with the development of obesity, insulin resistance and type-2 diabetes in adulthood. The results of studies on the correlation between BW and the severity of obesity and cardiovascular risk factors (CVRF) among obese children are contradictory. The objective of our study was to evaluate the association between birth weight and the presence of CVRF in genetically homogeneous group of obese children and adolescents.</...

hrp0094p2-214 | Fat, metabolism and obesity | ESPE2021

A study on the Complications associated with Severe Obesity in Children and Young People

Apperley Louise , Senniappan Senthil ,

Introduction: The complications of obesity are well recognised and documented in the adult population. There is little data available that reports the complications of childhood obesity seen in clinical practice. The aim of our study is to investigate the different types of complications seen in children and young people (CYP) with obesity.Methods: 125 CYP aged 0-18 years who had a body mass index (BMI) standard deviatio...

hrp0094p2-215 | Fat, metabolism and obesity | ESPE2021

The Effectiveness of Indigenous Knowledge-Based Lifestyle Interventions in Preventing Obesity and Type 2 Diabetes Mellitus in Indigenous Children in Canada

Kshatriya Maya , Wang Kuan-Wen , Hildebrand Julia , Crawford Rebecca , Nadarajah Ajantha , Youssef Michael , Rivas Angelica , Kaushal Ashleen , Banfield Laura , Thabane Lehana , Samaan Constantine ,

Background & Objective: Indigenous children in Canada have higher rates of obesity and type 2 diabetes mellitus (T2DM) and diabetes-related complications when compared to non-Indigenous children. Indigenous knowledge-based view of health encompasses a holistic approach with physical, mental, emotional, and spiritual health dimensions. This view of health will likely impact their engagement in interventions targeting obesity and T2DM. This systematic review...

hrp0094p2-216 | Fat, metabolism and obesity | ESPE2021

The effects of dextroamphetamine treatment in children with hypothalamic obesity

Samaan J , Welling MS , de Groot CJ , Abawi O , Burghard M , Kleinendorst L , van der Voorn B , van Haelst MM , Oude Ophuis B , Kamp GA , Rotteveel J , van Schouten-Meeteren AYN , van den Akker ELT , van Santen HM ,

Introduction: Children with hypothalamic dysfunction, e.g. due to a genetic or acquired cause such as suprasellar tumours, often suffer from hyperphagia and/or decreased resting energy expenditure (REE). This process induces uncontrollable weight gain, resulting in severe hypothalamic obesity (HO). No effective treatment is available yet for HO. Amphetamines are psychostimulants that are known for their appetite reducing and REE stimulating side effects. Here,...

hrp0094p2-217 | Fat, metabolism and obesity | ESPE2021

Nutritional status in premature infants born small by gestational age in the first 5 years of life

Kovalenko Tatyana , Yuditskiy Anton , Petrova Irina ,

There is not enough reasoned data on the dynamics of body weight indices in premature infants born small by gestational age (SGA).Aim: To study the nutritional status in premature babies born small by gestational age, in the first 5 years of life.Materials and Methods: The prospective study included preterm infant with SGA (n = 100) and prematurity corresponding to gestational age - AGA (n = 69) w...

hrp0094p2-218 | Fat, metabolism and obesity | ESPE2021

Impact of overweight and obesity in pediatrics. Metabolic syndrome and its components

San Martin Amaya , Vilella Leyre , Garcia Casales Zurine , Calvo Ariadne , Rocha C , Sarasua Miranda Ainhoa , Diez-Lopez Ignacio ,

The current lifestyle, with a diet increasingly removed from the Mediterranean diet, together with the habitual sedentary lifestyle, is associated with many of the so-called non-communicable diseases, such as the metabolic syndrome. Every day these pathologies are more frequent in pediatrics, so this study has tried to establish the prevalence of metabolic syndrome and its components in overweight and obese children and assess its impact. METHODS A descriptive study has been c...

hrp0094p2-219 | Fat, metabolism and obesity | ESPE2021

What do lipids tell us about the pandemic?

Campagnoli Myrna P , Lima Eloise M R , Cavalli Luana ,

The pandemic has changed habits in families around the world. Eating habits and physical activity were directly impacted by social distance. The first year of the pandemic left its mark on children’s health. The purpose of this analysis was to evaluate the relationship between the first year of the pandemic and the serum lipid profile in children who underwent lab tests in a private laboratory in Curitiba-PR.Methods: Observational a...

hrp0094p2-220 | Fat, metabolism and obesity | ESPE2021

Characteristics of eating behavior in children with type 1 diabetes and obesity

Waaks-Stępień Bogdan , Mikhno Hanna ,

Objective: to evaluate the characteristics of eating behavior in children with type 1 diabetes mellitus and various forms of obesity.Methods: We examined 80 children in the University Hospital (Minsk) in 2021. All children were divided into 2 groups: group 1 30 children (18 boys (B) (BMI 31.68±4.57 kg/m2, age 13.23±2.01 years) and 12 girls (G) (BMI 30.30±4.65 kg/m2, age 13.43±2.4...

hrp0094p2-221 | Fat, metabolism and obesity | ESPE2021

“Sleep Properly, Reduce Intake, aNd Get Stepping” (SPRINGS): a multidisciplinary approach to managing paediatric morbid obesity with severe obstructive sleep apnoea

Hawton Katherine , Oakley uliette , Welsh Kathryn , Kilpin Kate , McLean Cal , Easter Shelley , Langton Hewer Simon C , Hamilton Shield Julian P , Giri Dinesh ,

Introduction: Paediatric morbid obesity (BMI >99.6th centile for age) causes severe obstructive sleep apnoea (OSA) requiring respiratory support. Patient prognosis is poor and requires urgent intervention. Four patients with morbid obesity and severe OSA were admitted for multidisciplinary team (MDT) intensive weight management and continuous positive airway pressure (CPAP) initiation.Methods: The patients...

hrp0094p2-222 | Fat, metabolism and obesity | ESPE2021

Design of a Phase 2, Double-Blind, Placebo-Controlled Trial of Setmelanotide in Patients With Genetic Variants in the Melanocortin-4 Receptor Pathway

Farooqi Sadaf , Wabitsch Martin , Chung Wendy , Ohayon Olga , Scimia Cecilia , Yuan Guojun , Shah Bhavik , Stewart Murray ,

Background: Rare genetic causes of obesity include variants in genes within the melanocortin-4 receptor (MC4R) pathway, a principal regulator of energy balance. Weight and hunger reductions following treatment with the MC4R agonist setmelanotide have been demonstrated in patients with obesity due to variants in multiple genes, including POMC, LEPR, SRC1, and SH2B1. We describe a trial design of setmelanotide in patients with addition...

hrp0094p2-223 | Fat, metabolism and obesity | ESPE2021

Absence of dyslipidemia in obese children with BMI ≥2.5SDS and similar lipidemic profile to those with BMI <2.5SDS or normal weight

Leka-Emiri Sofia , Dikou Maria , Evangelopoulou Catherine , Kafetzi Maria , Petrou Vasilios , Vlachopapadopoulou Elpis , Michalacos Stefanos ,

Objective: Compare triglycerides, total cholesterol, HDL and LDL levels between obese and normal weight children.Methods: 547 children (286 females) with BMI (≥0SD) were divided in four groups (Group 1: 0SD<BMI<2SD, Group 2: 2SD≤BMI<2.25SD, Group 3: 2.25SD≤BMI<2.5SD, Group 4: BMI≥2.5SD) and analyzed retrospectively from the medical records. Age, sex, BMI z-score, triglycerides, tot...

hrp0094p2-224 | Fat, metabolism and obesity | ESPE2021

Inflammation associated to body composition in European prepubertal children: Results from the IDEFICS study

Argente Pilar , Esther Gonzalez , Intemann Timm , Moreno Luis , Molnar Denes , Kaprio Jaakko , Russo Paola ,

Background: Obesity is characterised by excessive fat accumulation coursing with a chronic mild inflammatory state, with adipose tissue (AT) being the main site of increased systemic cytokine production. Increased adiposity early in life is the main risk factor for cardiometabolic disorders later in life, with the abnormal accumulation of lipids in AT leading to the production of pro-inflammatory cytokines. Inflammatory process that involves metabolic and card...

hrp0094p2-225 | Fat, metabolism and obesity | ESPE2021

A case report of sitosterolemia and the early differential diagnosis

Zhang Jun , Ma Huamei , Chen Qiuli , Guo Song ,

Objective: To explore the clinical manifestations and early identification of sitosterolemia.Methods: To summarize the clinical characteristics of the case and review literatures of sitosterolemia.Result: The child was an 11-year-old boy. The main complaint was that subcutaneous yellow nodules were found more than 1 years with blood cholesterol increased for 4 months. Two months ago, the patient ca...

hrp0094p2-226 | Fat, metabolism and obesity | ESPE2021

Thyroid function in youth with metabolic syndrome

Tolstikova Olena ,

Introduction: Widespread obesity, as well as dystyroidism, dictates the investigation of possible thyroid dysfunction in young people with metabolic syndrome (MS).Aim: Study of thyroid status in young people with metabolic syndrome.Materials and methods: The study involved 46 patients (25 boys and 21 girls) with MS at the age of 18 ± 3.1 years. The inclusion criteria were an increase in body m...

hrp0094p2-227 | Fat, metabolism and obesity | ESPE2021

Global survey study of awareness, care and treatment of adolescents living with obesity, their caregivers and healthcare professionals: ACTION Teens

Halford Jason C.G. , Baur Louise , Bereket Abdullah , Bin-Abbas Bassam , Chen Walter , Fernandez-Aranda Fernando , Garibay-Nieto Nayely , Pedro Lopez Siguero Juan , Maffeis Claudio , Mooney Vicki , Karenina Osorto Cynthia , Reynoso Ricardo , Rhie Young-Jun , Toro-Ramos Martin ,

Background: Obesity rates in children and adolescents have increased dramatically across the globe, and the lifelong impact of obesity is more severe when onset begins at ≤20 years of age. However, the experiences, challenges and needs of adolescents living with obesity (ALwO), their caregivers, and the healthcare providers (HCPs) who treat them are poorly understood. ACTION Teens, the first study of its kind, aims to improve the lives of ALwO by generat...

hrp0094p2-228 | Fat, metabolism and obesity | ESPE2021

Lifestyle habits, consumption of non-nutritive sweeteners and obesity in students and young adults’ population in Latvia.

Roze Zane , Perle Eva , Krisane Iveta Dzivite , Grope Ilze ,

Background: Since 1975 the prevalence of obesity has tripled. As one of the habits of a healthy lifestyle is to reduce the fast sugars in our meals, the supply of non-nutritive sweeteners in the food supply has increased by offering sweeter meals without extra calorie intake.Objectives: To explore the characteristics of students and young adults’ lifestyle habits and consumption of non-nutritive sweeteners and their...

hrp0094p2-229 | Fat, metabolism and obesity | ESPE2021

Influence of the basal metabolic profile on the evolution of the pediatric patient with obesity

Diez-Lopez Ignacio , Fernandez Belen , Lorente Isabel , Sarasua-Miranda Ainhoa ,

Objective: To study how basal metabolism influences the somatometric evolution of the child and adolescent population with obesity in a pediatric endocrinology clinic; multichannel impedance study, TANITA BF 430.Results: 100 randomly selected patients from a database with 1400 records were studied. Most of the patients who come to these consultations for obesity are girls, between 8 and 11 years old. The group of boys at...