ESPE Abstracts (2021) 94 P2-194

1Belarusian State Medical University, Minsk, Belarus; 2Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk, Belarus

Objective: determination of changes in metabolic status and vitamin D concentrations in obese children.

Methods: We examined 221 children in the University Hospital (Minsk) from 2019 to 2021 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) - 159 patients (98 boys(B)/61 girls(G)) (BMI more than 99th percentile for sex and age) (BMI 33.04±4.67 kg/m2, age 13.17±2.42 years); group 2 - 62 patients (B/G=31/31) with alimentary obesity (AO) (BMI-95-99th percentile for sex and age) (BMI 27.60±2.06 kg/m2, age 13.43±2.27 years). The control group (C) consisted of 60 patients (B/G=30/30) with normal body weight (BMI 19.86±2.24 kg/m2, age 13.32±2.30 years).

Results: In boys and girls with obesity higher concentrations of insulin were detected relative to the control group (АО (G 16.36 (9.90–19.20) µU/ml; B 17.07 (8.40–20.00) µU/ml) and МО (G 21.06 (12.60–24.50) µU/ml; B 20.79 (12.75–25.40) µU/ml); С (G 8.35 (5.90–11.30) µU/ml ; B 9.83 (7.90-11.40) µU/ml) (G UАО-К=228.00; р=0.0001; UМО-К=276.00; р=0.0001; B UАО-К=493.50; р=0.0001; UМО-К=641.00; р=0.0001)). Insulin resistance index level (HOMA-IR) in patients with О (G 3.23 (1.97–3.94); B 3.49 (1.75–4.27)) and МО (G 4.14 (2.37–5.32); B 4.31 (2.55–5.46)) was higher than in the control (G 1.60 (0.99–2.18); B 1.89 (1.53–2.30)) (G UАО-К=219.00; р=0.0001; UМО-К=304.00; р=0.0001; B UАО-К=1050.50; р=0.0001; UМО-К=592.50; р=0.0001). In patient of the study group a significant decrease in the level of vitamin D (G АО 25.90 (22.53–30.58) vs 39.36 (32.00–45.94) ng/ml; U=67.00; р=0.0001; G МО 20.18 (15.22–25.60) vs 39.36 (32.00–45.94) ng/ml; U=36.50; р=0.0001; B АО 27.57 (24.03–31.78) vs 36.12 (30.77–41.69) ng/ml; U=161.50; р=0.0001; B МО 23.01 (17.94–28.89) vs 36.12 (30.77–41.69) ng/ml; U=327.00; р=0.0001).

Conclusion: Children with obesity have a significant decrease in the concentration of vitamin D.

Volume 94

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

European Society for Paediatric Endocrinology 

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