ESPE2021 ePoster Category 2 Fat, metabolism and obesity (59 abstracts)
Early decline in Sertoli cell function during puberty in overweight and obese boys: a cross-sectional study
Solène Rérat 1 , Jessica Amsellem-Jager 1 , Marie-Clémence L’hours 2 , Natacha Bouhours-Nouet 1 , Aurélie Donzeau 1 , Stéphanie Rouleau 1 , Lucie Levaillant 1 , Fabienne Emeriau 1 , Valérie Moal 1 , Florence Boux de Casson 1 , Najiba Lahlou 3 & Régis Coutant 1
1Angers University Hospital, Angers, France; 2Children’s Hospital, Lorient, France; 3Biological Endocrinology, Pannes, France
Context: Alterations in semen characteristics and Sertoli and Leydig cell function have been described in obese male adults. Whether these alterations occur before adulthood has not been fully evaluated.
Objective and Design: Cross sectional study from 2010 to 2018 describing gonadic function in overweight-obese (ow/ob) boys through childhood and adolescence.
Setting: Monocentric study in the Pediatric Endocrinology Unit of Angers University Hospital.
Patients, intervention, and main outcome measures: 351 obese and overweight boys aged 5 to 19 years underwent physical examination, dual-energy X-ray absorptiometry for body composition, OGTT on insulin and glucose, and measurements of FSH, LH, anti-Mullerian hormone (AMH), inhibin B, testosterone, and estradiol. Hormonal levels were compared to normative data obtained from 652 lean healthy boys of similar age or Tanner stage.
Results: The increase in median inhibin B and testosterone levels during puberty was significantly lower in ow/ob compared to lean boys (i) from age > 12 years and thereafter for inhibin B, and (ii) from age > 14 years and thereafter for testosterone. At Tanner stages 4 and 5, 26%, 31%, and 18% of inhibin B, testosterone, and AMH values, respectively, were below the 5th percentile in ow/ob subjects (P < 0.01). In multiple regression analyses, estradiol and total bone mineral density Z-score were negative predictors of inhibin B, fat mass percentage was a negative predictor of testosterone, and insulin was a negative predictor of AMH.
Conclusion: An early decline in Sertoli cell function preceding that in Leydig cell function was observed during puberty in the ow/ob boys.
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