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59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

ESPE Yearbook Sessions

Year of Paediatric Endocrinology 2

hrp0094yb2.1 | Year of Paediatric Endocrinology 2 | ESPE2021

DSD and Transgender - Updates 2021

Flueck Christa , Cools Martine , Nordenstrom Anna ,

In the past year, basic and genetic studies revealed again novel genes and mechanisms implicated in 46,XX and 46,XY DSD. The Fgf9-/- mouse model of human synostosis syndromes revealed an unexpected male-to-female sex reversal phenotype, so far not observed in humans. Specific heterozygous human WT1 gene variants located in the 4th zinc finger were found to cause 46,XX virilization due to (ovo-)testicular DSD, and the transcription factor...

hrp0094yb1.2 | Year of Paediatric Endocrinology 2 | ESPE2021

Antenatal and Neonatal Endocrinology

Hussain Khalid ,

I have chosen 3 manuscripts for my year book presentation on antenatal and neonatal endocrinology. The first manuscript describes the use of induced pluripotent stem cells (iPSCs) to study the genetic mechanisms of congenital hyperinsulinism (CHI). The derivation of iPSCs and their subsequent conversion to islet like clusters from a patient with diffuse CHI due to a homozygous mutation in the ABCC8 provides a unique opportunity to study the molecular basis of CHI and ...

hrp0094yb2.4 | Year of Paediatric Endocrinology 2 | ESPE2021

Oncology and Chronic Disease

Bizzarri Carla ,

As in previous years, most of the studies concern the medium and long-term complications of cancer therapy. Issues related to long-term surveillance strategies represent an emerging topic of discussion. In comparison with previous years, this year we have found few truly original and innovative studies. Rather, the attention of the researchers seems to be focused on confirming and consolidating acquired data, in particular: - The development of subsequent neoplasms in childhoo...