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59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.


Calcium and Phosphate Beyond Bone

hrp0094s11.1 | Calcium and Phosphate Beyond Bone | ESPE2021

Phosphate toxicity: focus on medial vascular calcification

Voelkl Jakob ,

Inorganic phosphate is essential for bone stability and various cellular metabolic pathways. Serum phosphate levels are regulated by an endocrine triangle of calcitriol, parathyroid hormone and fibroblast growth factor 23. In addition, a mineral buffering system is required to prevent mineral stress and ectopic calcification by spontaneous precipitation of calcium and phosphate. Current research indicates a complex interplay of phosphate homeostasis and inflammatory processes,...

hrp0094s11.2 | Calcium and Phosphate Beyond Bone | ESPE2021

Vitamin D and male reproduction

Blomberg Jensen Martin ,

Newer studies have indicated that vitamin D has more widespread effects than the classical effects on bone and calcium-phosphate homeostasis. The presence of the vitamin D receptor (VDR) in the testis and male reproductive tract indicates a role for vitamin D in male reproduction. Indeed, vitamin D deficiency and global knock out models of VDR or CYP27B1 in rodents have shown that vitamin D and calcium are important regulators of male reproductive function. Several groups have...