ESPE Abstracts

Circadian clock system is an evolutionarily conserved system, by which organisms adapt their metabolic activities to environmental inputs including nutrient availability. The master pacemaker of the clock system is located in the suprachiasmatic nucleus (SCN) in the hypothalamus. The neurons in the SCN are entrained by the signals from the light through the retinal-hypothalamic tract and the light-dark cycle of the environment creates the rhythmic patterning of behavioral and ...

The calcium-sensing receptor (CaSR) is the master regulator of calcium homeostasis. This class C G-protein coupled receptor binds extracellular calcium and phosphate, and is the target of calcimimetic and calcilytic drugs. The CaSR is expressed on the cell surface as a homodimer and is most highly expressed in the parathyroid glands and the renal thick ascending limb, where it acts to maintain a near-constancy of plasma calcium concentrations by regulating parathyroid hormone ...