Previous issue | Volume 94 | ESPE2021

59th Annual ESPE (ESPE 2021 Online)

Online,
22 Sep 2021 - 26 Sep 2021

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The 59th ESPE Annual Meeting will now be held online in September 2021.

Symposia

Recent Breakthroughs in our Understanding of Calcium and Phosphate Homeostasis

hrp0094s2.1 | Recent Breakthroughs in our Understanding of Calcium and Phosphate Homeostasis | ESPE2021

Circadian rhythms of skeletal homeostasis.

Kawai Masanobu ,

Circadian clock system is an evolutionarily conserved system, by which organisms adapt their metabolic activities to environmental inputs including nutrient availability. The master pacemaker of the clock system is located in the suprachiasmatic nucleus (SCN) in the hypothalamus. The neurons in the SCN are entrained by the signals from the light through the retinal-hypothalamic tract and the light-dark cycle of the environment creates the rhythmic patterning of behavioral and ...

hrp0094s2.2 | Recent Breakthroughs in our Understanding of Calcium and Phosphate Homeostasis | ESPE2021

Calciotropic and non-calciotropic roles of the calcium sensing receptor

Hannan Fadil ,

The calcium-sensing receptor (CaSR) is the master regulator of calcium homeostasis. This class C G-protein coupled receptor binds extracellular calcium and phosphate, and is the target of calcimimetic and calcilytic drugs. The CaSR is expressed on the cell surface as a homodimer and is most highly expressed in the parathyroid glands and the renal thick ascending limb, where it acts to maintain a near-constancy of plasma calcium concentrations by regulating parathyroid hormone ...