ESPE Abstracts (2021) 94 FC9.5

ESPE2021 Free Communications Growth Hormone and IGFs (6 abstracts)

Dynamic Changes in Growth and IGF-I During the First Year of Life; A Longitudinal Study of 233 healthy Danish Infants

Emmie N. Upners 1,2 , Marie L Ljubicic 1,2 , Alexander S Busch 1,2 , Margit B Fischer 1,2 , Kristian Almstrup 1,2 , Jørgen H Petersen 1,2 , Rikke B Jensen 1,2 , Casper P Hagen 1,2 & Anders Juul 1,2,3

1Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.;2International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.;3Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark

Background: Growth during infancy is a continuation of the rapid fetal growth and its regulation is complex and multifactorial. It is well-established that insulin-like growth factor-I (IGF-I) and its regulators (e.g. IGF binding proteins (IGFBP-3) and pregnancy-associated plasma protein-A2 (PAPP-A2)) are important for prenatal and postnatal growth; however, their significance for growth during infancy is not fully explored.

Aims: The aim of this study was to evaluate length velocity, weight velocity and IGF-I concentrations and to explore the association between length and weight velocities and repeated IGF-I measurements in a large cohort of healthy infants followed prospectively from birth throughout first year of life.

Method: 233 infants (114 girls and 119 boys) participated in the longitudinal COPENHAGEN Minipuberty Study. We examined the infants six times during the first year of life. Length, weight and IGF-I were measured, and length and weight velocities were calculated. The infants were genotyped for PAPPA2 (rs1325598).

Results: Length and weight velocities were high after birth, declined gradually and stabilized around 7th month of age in both boys and girls, but with markedly higher velocities and steeper declines in boys than in girls. At birth, IGF-I concentrations were higher in girls compared with boys (median concentration 78.7 and 69.5 µg/l, respectively, P = 0.05), and increased significantly from birth to 10 days in boys (mean difference 24.8 ± 34.05 SD µg/l, P < 0.001), but not in girls. Hereafter, IGF-I concentration increased significantly throughout the entire first year of life. In a univariate analysis, both mean length velocity (standard deviation score (SDS)) and mean weight velocity (SDS) were positively associated with mean IGF-I (SDS) (β=0.12 (95% CI, -0.0001-0.24), P = 0.05 and β=0.25 (95% CI, -0.14-0.08), P < 0.001). However, in a multiple regression analysis, only mean weight velocity (SDS) remained associated with IGF-I after adjusting for confounding factors (feeding pattern, birth weight, target height, body fat %, and PAPPA2 genotype) (β=0.19 (95% CI, 0.05-0.33), P = 0.01).

Conclusion: We present individual growth trajectories during the first year of life in 233 Danish infants. Weight velocity, but not length velocity, was positively associated with serum IGF-I concentration, but not PAPPA2 genotype. This indicates that IGF-I promotes an overall gain in weight rather than length during first year of life.

Volume 94

59th Annual ESPE (ESPE 2021 Online)

22 Sep 2021 - 26 Sep 2021

European Society for Paediatric Endocrinology 

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