ESPE2021 ePoster Category 1 Sex Endocrinology and Gonads B (10 abstracts)
Screening of serum differential proteins in girls with rapidly progressing central precocious puberty with TMT quantitative proteomics
Rongrong Xie , Dandan Zhang , Haiying Wu , Fengyun Wang , Xiuli Chen , Ting Chen , Hui Sun , Xiaoyan Wang , Mengjia Song & Linqi Chen
Department of Endocrinology, Children’s Hospital of Soochow University, Suzhou, China
Objective: To screen and identify serum differentially expressed proteins in girls with rapidly progressing central precocious puberty and healthy girls by proteomics.
Methods: 15 idiopathic central precocious puberty girls and 15 healthy children were admitted to the Children’s Hospital of Suzhou University from August 2017 to October 2018.After mixing in the group, the high-abundance protein was removed and quantified with proteomics tandem mass tag (TMT) labeling technique. Gene functional clustering (GO) analysis and pathway enrichment analysis were performed on the identified differential proteins to screen for proteins associated with the development of rapidly progressive central precocious puberty.
Results: Mass spectrometry identified 504 proteins with >95% confidence, of which 83 were differentially expressed. Compared with the control group, 31 of the 83 differential proteins were up-regulated and 52 were down-regulated. GO analysis showed that most of the differential proteins were in the extracellular region (36%); KEGG pathway enrichment analysis showed that the pathway with the largest number of differential proteins was the protein digestion and absorption pathway.
Conclusion: The differential proteins associated with protein digestion and absorption pathways have been identified in the serum of girls with rapidly progressing central precocious puberty, and their specific functions need further study.
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