ESPE2021 ePoster Category 1 Bone A (10 abstracts)
Leptin to adiponectin ratio at the age of 12 is negatively associated with lumbar spine bone mineral apparent density independently of body fat mass in 18-year old males.
Reeli Tamme 1,2 , Jaak Jürimäe 3 , Evelin Mäestu 3 , Liina Remmel 3 , Priit Purge 3 , Eva Mengel 2 & Vallo Tillmann 1,2
1Children’s Clinic of Tartu University Hospital, Tartu, Estonia; 2Institute of Clinical Medicine, University of Tartu, Tartu, Estonia; 3Institute of Sports Sciences and Physiotherapy, Tartu, Estonia
Background: Inconsistent associations of leptin and adiponectin with bone mineral characteristics in puberty and adolescence have been reported.
Aim: To examine associations between leptin to adiponectin ratio (LAR) in puberty and bone mineral characteristics at 18 years of age and increase of bone mineral characteristics until 18 years of age.
Materials and methods: 88 boys were investigated with a mean age of 12.1±0.7 (T1), 14.0±0.7 (T2) and 18.0±0.7 (T3). Serum leptin and adiponectin were measured at all time points and LAR was calculated. Bone mineral density (BMD) and bone mineral content (BMC) were measured for total body (TB) and lumbar spine (LS) at T1 and T3, bone mineral apparent density (BMAD) was calculated. As different brands of DEXA machines were used at T1 and T3, we calculated standard deviation scores (SDS) from present samples at T1 and T3 and their change (Δ). Partial correlation analyses was performed with body fat percentage, testosterone, HOMA-IR and physical activity as covariates.
Results: Significant negative correlation was found between mean pubertal LAR and LS BMD at T3 (r = -0.311; P < 0.05) and LS BMAD at T3 (r = -0.405; P < 0.05). Moreover, pubertal LAR correlated significantly with Δ LS BMD SDS (r= -0.397; P < 0.05) and Δ LS BMAD SDS (r = -0.415; P < 0.05).
Conclusion: LAR in puberty is negatively associated with LS BMD and LS BMAD at the age of 18 years and with subsequent increase in relative LS BMD and LS BMAD by the age 18 years.
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