ESPE Abstracts

Objective: We aimed to evaluate the relationship between serum myostatin levels and metabolic parameters in children with insulin dependent (Type 1) diabetes mellitus and to show the relationship with sarcopenia in children with insulin dependent diabetes mellitus.

Methods: Forty -four patients aged between 8 and 16 years, and 45 control patients were enrolled in the study. Anthropometric measurements and laboratory analysis were performed. Serum myostatin levels were studied in both groups. Body analysis was done to the patient and control groups. Lean body mass ratio was detected.

Results: There was a statistically significant difference between the patient and control groups in terms of the myostatin level (P <0.01). The mean “Myostatin” value of the participants in the patient group (33,17 ng/ml) was significantly higher than the mean “Myostatin” value of the participants in the control group (13,60 ng/ml). There was a statistically significant difference between the patient and control groups in terms of “CPK” (P <0.05). The mean “CPK” value in the patient group was lower than the control group. Although there was no statistically significant relationship between myostatin values and “HbA1c”, “C-peptide”, “Insulin” and “CPK” variables, there was a negative correlation with “CPK”, “insulin” and “C- peptide” levels and positive correlation with “HbA1c”.

Conclusions: Serum myostatin levels were higher in children and adolescents with insulin dependent diabetes mellitus than in control group, regardless of muscle mass. It was found to be positively correlated with HbA1c. This result may indicate that serum myostatin levels may have potential new pathological effects on muscle mass and metabolism, especially in children and adolescents with poorly controlled insulin dependent diabetes mellitus. Further studies are needed on the subject.