ESPE Abstracts

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia in adults are a high plasma triglyceride concentration, low HDL cholesterol concentration and increased LDL cholesterol. Dyslipidaemia in children with type 1 diabetes mellitus (T1D) have been little studied (P. Lozano et al., 2016; J. D. Schofield et al.,2016; M. Kinoshita et al., 2018; C.Elkins et al., 2019). DECODE studies (Diabetic Epidemiology: Collaborative Analysis of Diagnostic Criteria in Europe, 2003) have shown that postprandial hyperglycemia and postprandial hypertriglyceridemia is strongly associated with occurrence of cardiovascular diseases. Purpose. To study the features of changes in the blood lipid levels in children with type I diabetes.

Patients and methods: The blood lipid and lipoprotein spectrum was biochemically studied in 60 children with T1D aged 6-19 years. The total cholesterol, triglycerides, lipoproteins of the low density (LDL) and high density (HDL) and glycemic profile were determined. The study was performed in accordance with the Declaration of Helsinki. Data was analyzed using SPSS Statistics v 24.0.0.0. A P < 5 was considered to be statistically significant.

Results: Depending of the level of postprandial glycemia (PPG) all patients were divided into three groups: group I – with PPG 5-10 mmol/l and group II – children with PPG PPG >10 mmol/l. In group I dyslipidemia was determined in 16%, in group II – in 71% (P < 0.001). Hypercholesterolemia, hypertriglyceridemia and low HDL were present in in surveyed patients. Hypertriglyceridemia was positively correlated with PPG level in group II (r = 0.55).

Conclusions: Hypertriglyceridemia and low HDL cholesterol is common in children with T1D and high postprandial glycemia levels (above 10 mmol/l). This suggests that children with T1D, high postprandial glycemia levels and dyslipidemia need specific management.