ESPE Abstracts

Objective(s): Type 1 Diabetes Mellitus (T1DM) is associated with poor bone health. It is shown that the increased fracture risk in T1DM is multifactorial. The aim of current study is to determine the body weight correlation with bone mineral density (BMD) in type 1 diabetic non-obese patients.

Materials and Methods: To evaluate the factors associated with bone mineral density in type 1 diabetic patients a total of 45 patients with T1DM, aged 20-35 years, with a duration of diabetes >5 years were investigated. The serum levels of 25-hydroxyvitamin D3 (25OHD3), glucose, thyroid hormones, and glycosylated hemoglobin (HbA1c) were evaluated. Anthropometric measurements were carried out, the Body Mass Index (BMI) was calculated. BMD was evaluated using dual energy X-ray absorptiometry (DXA). Statistical analyses were performed with SPSS Version21.0 to determine the significance of findings. In all cases null hypothesis was rejected if P<0.05.

Results: Significantly positive correlations were found between body weight and forearm BMD (P<0.01), body weight and foramen nek BMD (P<0.01). The mean levels of 25OHD3 concentration found to be higher in male than in female patients, 19.5ng/ml and 16,7ng/ml, respectively, without statistical significance (P>0.05). No any significant connection was revealed between duration of diabetes, HbA1c and BMDs.

Conclusion: Body weight modification in young T1DM patients can be considered as a correlative measure of BMD to predict the further risk of possible low BMD and osteoporosis development. Current results indicate the need of new larger studies to investigate the direct and indirect effects of T1DM on the bone health in early young age.