ESPE Abstracts (2022) 95 P1-357

ESPE2022 Poster Category 1 Pituitary, Neuroendocrinology and Puberty (77 abstracts)

The Prolactin (PRL) – Growth Hormone (GH) Relationship during Growth Hormone Stimulation Tests

Zvi Laron , Avivah Silbergeld , Chen Barazani & Pearl Lilos


Schneider Children’s Medical Centre, Petah Tikva, Israel


Background: Despite many similarities between the structure, receptors and proliferative and growth promoting actions, the interrelationship between PRL and GH in clinical conditions has received little attention.

Aim: To determine the PRL response to GH stimulation tests.

Subjects: Prepubertal and early pubertal boys (n=581) and girls (n=502) with short stature.

Methods: Data was retrieved from the computerized records of the Endocrine Laboratory. Peak GH and PRL levels during GH stimulation tests with glucagon (Gluc), clonidine (Clon) and clonidine with arginine (Clon+Arg), were determined by radioimmunoassay. Statistical analysis was performed by ANOVA with repeated measurements.

Results: The comparative values of peak GH and PRL (mean ng/l ± SD) are shown in the Table.

TEST   BOYS     GIRLS  
  n AGE (y) GH peak PRL n AGE (y) GH peak PRL
Gluc 264 9.6 ± 4.4 9.0 ± 5.3 8.6 ± 6.7 217 9.0 ± 3.6 9.0 ± 5.4 9.4 ± 7.6
Clon 178 9.8 ± 3.8 12.4 ± 6.2 6.5 ± 3.8 160 9.5 ± 3.3 11.1 ± 6.0 6.7 ± 3.5
Clon+Arg 139 12.9 ± 2.7 14.9 ± 7.3 6.8 ± 3.5 ƚ 125 11.6 ± 1.9 15.8 ± 7.6 6.6 ± 3.3
PRL: Gluc vs Clon/Clon+Arg P<0.0005

Whereas Gluc stimulated both GH and PRL to similar levels, Clon alone or combined with Arg suppressed PRL secretion (P<<0.0001). It is also evident that in both boys and girls, Clon±Arg are superior to Gluc in GH stimulation. The higher GH levels during Clon+Arg can be attributed to the pubertal stage.

Conclusion: Our study helps to select the appropriate PRL function test in relation to GH.

Ref:

Laron Z. The Growth Hormone - Prolactin Relationship: A Neglected Issue. Pediat Endocrinol Rev 2011; 9:546-8

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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