ESPE2022 Poster Category 1 Pituitary, Neuroendocrinology and Puberty (77 abstracts)
Background: Despite many similarities between the structure, receptors and proliferative and growth promoting actions, the interrelationship between PRL and GH in clinical conditions has received little attention.
Aim: To determine the PRL response to GH stimulation tests.
Subjects: Prepubertal and early pubertal boys (n=581) and girls (n=502) with short stature.
Methods: Data was retrieved from the computerized records of the Endocrine Laboratory. Peak GH and PRL levels during GH stimulation tests with glucagon (Gluc), clonidine (Clon) and clonidine with arginine (Clon+Arg), were determined by radioimmunoassay. Statistical analysis was performed by ANOVA with repeated measurements.
Results: The comparative values of peak GH and PRL (mean ng/l ± SD) are shown in the Table.
|n||AGE (y)||GH peak||PRL||n||AGE (y)||GH peak||PRL|
|Gluc||264||9.6 ± 4.4||9.0 ± 5.3||8.6 ± 6.7||217||9.0 ± 3.6||9.0 ± 5.4||9.4 ± 7.6|
|Clon||178||9.8 ± 3.8||12.4 ± 6.2||6.5 ± 3.8||160||9.5 ± 3.3||11.1 ± 6.0||6.7 ± 3.5|
|Clon+Arg||139||12.9 ± 2.7||14.9 ± 7.3||6.8 ± 3.5 ƚ||125||11.6 ± 1.9||15.8 ± 7.6||6.6 ± 3.3|
|PRL: Gluc vs Clon/Clon+Arg P<0.0005|
Whereas Gluc stimulated both GH and PRL to similar levels, Clon alone or combined with Arg suppressed PRL secretion (P<<0.0001). It is also evident that in both boys and girls, Clon±Arg are superior to Gluc in GH stimulation. The higher GH levels during Clon+Arg can be attributed to the pubertal stage.
Conclusion: Our study helps to select the appropriate PRL function test in relation to GH.
Laron Z. The Growth Hormone - Prolactin Relationship: A Neglected Issue. Pediat Endocrinol Rev 2011; 9:546-8
15 Sep 2022 - 17 Sep 2022