ESPE Abstracts

The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study included 88 children aged 1-18 years (M/F- 35/53), diabetic patients of Diabetology Outpatient Clinic and Department of Pediatrics, Endocrinology, Diabetology with Subdivision of Cardiology, Medical University of Bialystok. The group of 43 children with type 1 diabetes (diagnosed by ISPAD criteria) was compared to the control group of 45 healthy children with a negative history of autoimmune diseases, inflammatory diseases and cancer. The diabetic group was divided into 4 subgroups regarding the duration of type 1 diabetes: (I) newly diagnosed patients, after an episode of ketoacidosis (n = 14), (II) patients with type 1 diabetes of duration no longer than 5 years (n = 13), (III) patients with 5 to 10 years of diabetes type 1 (n = 11), (IV) patients with type 1 diabetes of duration longer than 10 years (n=5). The mean levels of kallistatin, decorin and vaspin in all subgroups were higher than in the control group. The differences between the respective subroups and the control group were statistically significant for decorin and kallistatin (P<0.0005), but not for vaspin (P>0.05). Moreover, the mean levels of tested peptides were fluctuated during the course of the disease. We observed the highest levels of kallistatin, decorin and vaspin in the subgroup of children with type 1 diabetes of duration not longer than 5 years, which may be of importance in the development of the disease complications.