ESPE Abstracts (2022) 95 P2-104

ESPE2022 Poster Category 2 Fat, Metabolism and Obesity (36 abstracts)

Leptinemia and cardiometabolic risk factors in genetic obesity syndromic in children : Prader Willi and Bardet Biedl

Asmae Touzani 1,2 , Jocelyne Drai 3 , Amina Balafrej 1 , Ahmed Gaouzi 1 & Layachi Chabraoui 2


1Department of Diabetology-Endocrinology-Neurology-Pediatric-Children's Hospital, Rabat, Morocco; 2Department of Biochemistry University Mohammed V Souissi -Faculty of Medicine and Pharmacy, Rabat, Morocco; 3Laboratory of Biochemistry, Hospital Southern, Lyon, Lyon, France


Obesity is a state of imbalance between food intake and energy expenditure leading to a positive energy balance. This condition may be due to the existence of a genetic syndrome: the Prader-Willi syndrome (PWS) is the genetic cause the most common obesity and Laurence-Moon Bardet-Biedl syndrome (BBS), autosomal recessive.

Objectives: Our objective is to compare the cardio-metabolic risk factors in children with obesity gene to those of children with simple obesity and those of healthy subjects of similar age and sex.

Materiel and Methods: This is 13 patients with a genetic syndrome (PWS 8 and 5 SBB). They are followed in consultation-Pediatric Endocrinology (HER) over a period of 7 years. Their average age: 8.7 ± 4.1 years, their mean BMI: 31.19 ± 6.24 kg/m2. The subjects with simple obesity (controls) (n = 15) are chosen in a random way same age, same sex and BMI as obese with a genetic syndrome. The controls (n = 14) had a mean age of 8.9 ± 4.6 years. Their average BMI was 17.01 ± 2.13 kg/m2. Serum lipids (TC, HDL-C, TG) and glucose were measured by an enzymatic method. Serum levels of leptin, insulin have been determined by an immunoassay method.

Results: Insulin resistance was assessed by HOMA-IR, FIGR, Fcb and the insulin sensitivity index QUICKI. Patients with a genetic syndrome show a significant elevation of triglycerides, lower HDL-cholesterol and increased plasma leptin. It‘s increased insulin resistance (HOMA-IR, FIGR, Fcb) and lower insulin sensitivity (QUICKI index). There's an increased rate of leptin, the FIGR and Fcb in obese with a genetic syndrome (PWS and BBS) compared with obese controls.

Conclusion: This work confirms that obesity due to genetic abnormality is associated with disruption of important risk factors cardiovascular.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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