ESPE Abstracts

Objective: Determination of changes in metabolic status and vitamin D concentrations in obese children.

Methods: We examined 210 children in the University Hospital (Minsk) from 2021 to 2022 yrs. Their anthropometric parameters (height, weight, body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. All children were divided into 2 groups: group 1 children with morbid obesity (MO) - 148 patients (88 boys(B)/60 girls(G)) (BMI more than 99th percentile for sex and age) (BMI 33.04±4.67 kg/m2, age 13.17±2.42 years); group 2 - 62 patients (B/G=31/31) with alimentary obesity (AO) (BMI-95-99th percentile for sex and age) (BMI 27.60±2.06 kg/m2, age 13.43±2.27 years). The control group (C) consisted of 60 patients (B/G=30/30) with normal body weight (BMI 19.86±2.24 kg/m2, age 13.32±2.30 years).

Results: In boys and girls with obesity higher concentrations of insulin were detected relative to the control group (АО (G 16.36 (9.90–19.20) µU/ml; B 17.07 (8.40–20.00) µU/ml) and МО (G 21.06 (12.60–24.50) µU/ml; B 20.79 (12.75–25.40) µU/ml); С (G 8.35 (5.90–11.30) µU/ml; B 9.83 (7.90-11.40) µU/ml) (G UАО-С=228.0; р<0.001; UМО-С=276.0; р<0.001; B UАО-С=493.5; р<0.001; UМО-С=641.0; р<0.001)). Insulin resistance index level (HOMA-IR) in patients with АО (G 3.23 (1.97–3.94); B 3.49 (1.75–4.27)) and МО (G 4.14 (2.37–5.32); B 4.31 (2.55–5.46)) was higher than in the control (G 1.60 (0.99–2.18); B 1.89 (1.53–2.30)) (G UАО-С=219.0; р<0.001; UМО-С=304.0; р<0.001; B UАО-С=1050.5; р=0.001; UМО-С=592.5; р<0.001). In patient of the study group a significant decrease in the level of vitamin D in the blood serum was registered in comparison with the control group, regardless of gender (G AO 25.90 (22.53–30.58) vs 39.36 (32.00–45.94) ng/ml, U=67.0, P<0.0001, G MO 20.18 (15.22–25.60) vs 39.36 (32.00–45.94) ng/ml, U=36.5, P=0.001, BAO 27.57 (24.03–31.78) vs 36.12 (30.77–41.69) ng/ml, U=161.50, P=0, 0001; B MO 23.01 (17.94–28.89) vs 36.12 (30.77–41.69) ng/mL; U=327.0; P=0.001). In boys with obesity higher concentrations of OPG were detected relative to the control group (АO 210.89±20.17 ng/ml vs 189.1±11.21 ng/ml (P=0.05), MO 222.22±21.14 ng/ml vs 189.1±10.21 ng/ml (P=0.03)).

Conclusion: Changes in metabolic status were registered in obese patients: an increase in insulin, OPG levels and a decrease in vitamin D compared with children with normal body weight.