ESPE2022 Poster Category 2 Fetal, Neonatal Endocrinology and Metabolism (16 abstracts)
Relationship Between Birth Body Weight≪10.Th Centile (Sga) And Insulin-Like Growth Factor Binding Protein-2 / Insulin-Like Growth Factor Binding Protein-3 Ratio In The Not-Life Threatened Newborn: Relevance Of Birth Chest Circumference / Birth Body Weight Ratio
Cesare Terzi 1,2 , Raffaele Virdis 1,2 , Cristiana Magnani 3,4 , Gabriele Tridenti 3,4 , Andrea Cerioli 5 , Marco Riani 5 , Lidia Garavelli 6,4 , Sergio Bernasconi 1,2 , Gian Luigi De Angelis 1,2 , Werner F. Blum 7 & Giacomo Banchini 8,4
1Department of Medicine and Surgery - University of Parma, Parma, Italy; 2Dipartimento Materno-Infantile - Azienda Ospedaliero-Universitaria di Parma, Parma, Italy; 3Dipartimento Materno-Infantile, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy; 4S. Maria Nuova Hospital, Reggio Emilia, Italy; 5Department of Economics - University of Parma, Parma, Italy; 6Dipartmento Materno-Infantile, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy; 7Children's University Hospital - University of Giessen, Giessen, Germany; 8Dipartment Materno-Infantile, AUSL-IRCCS Reggio Emilia, Reggio Emilia, Italy
Birth chest circumference(CC) shows often, like birth gestational age(GA), tight direct relations to birth body weight(BW). However distinct connections of hypoxia/undernutrition with different body structures might be suspected based on brain-, heart- and adrenal-sparing following intrauterine growth restriction and, postnatally, on higher chest size for body mass observed at high altitude. Growth retarded fetuses gestated by hypoxic rats may present increments of blood serum Insulin-like Growth Factor Binding Protein(IB) 2, but not of IB3. Relevance of human newborn(NWB) CC/BW ratio(i.e., CC through BW, CC/BWR) to relationships between BW<=10.th centile for GA(SGA), and IB2/IB3 ratio(IB2/IB3R) was evaluated. NWBs with any among total parenteral nutrition, parenteral nutrition other than dextrose, blood component transfusion, postnatal corticosteroid-, catecholamine- or methylxantine-based treatments, life-threatening disease, diabetes mellitus(DM) or other endocrine diagnosis, malformation, and mother with DM were excluded. 78 included NWBs, all studied before covid-19 pandemic and from conception to study end near sea-level, had complete data for 1) same-day records at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z) of postnatal age(PNA, unit:day), IB2 and IB3 radioimmunoassay(unit=uM/dl), and for 2) gender(SEX), GA(unit: complete week; extremes=28–42), GA<=36 present(PTB, n=46), CC(25th-75th centiles=27-32 cm), BW(25th-75th centiles=1926-2942g), and SGA(n=20)(computations; male SEX(n=43), SGA; condition absent=0, condition present=1). SPSS-27 software was used to generate GA-unrelated CC/BWR standardized residuals(CC/BWRsr)(i.e., Linear regression procedure-Save pushbutton/ Standardized residual checkbox-Continue pushbutton/ regress CC/BWR on only GA). IB2/IB3R(i.e., IB2 through IB3) calculated at x-y-z time-poins, was averaged(i.e., (x+y+z)/3; IB2/IB3RM). IB2/IB3RM normal scores according to Van der Waerden(IB2/IB3RM-NS) were normally distributed. SGA evidenced significantly higher CC/BWR, CC/BWRsr and IB2/IB3RM than non-SGA(Mann-Whitney Test). Spearman rank correlations between the following variable pairs are reported(Rho; significance): GA vs CC/BWR(-.706, P<.0001), GA vs CC/BWRsr(-.024; P=.8315), GA vs IB2/IB3R(-,409; P=.0002), CC/BWRsr vs IB2/IB3R(.346; P=.0019). Partial correlation(pc) coefficient(pcc) of SGA pc with outcome IB2/IB3RM-NS in multiple linear regression(MLR) was significant (t=4.194, P<.0001, pcc=.565) with SEX-GA-SGA-PNAx as predictors, but non-significant with SEX-GA-SGA-CC/BWRsr-PNAx as predictors(MLR R2,. 447-.492, always significant). CC/BWRsr could be involved in direct relationships between SGA and IB2/IB3RM-NS after controls including GA in not-life-threatened NWBs.
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