ESPE2022 Poster Category 2 Thyroid (22 abstracts)
Thyroid Function and Congenital Heart Defects in Children with Down Syndrome at Hasan Sadikin General Hospital, Bandung, Indonesia
Dwi Andriyani 1 , Novina Novina 2,3 , Putria Rayani Apandi 4,3 , Faisal Faisal 2,3 , Rahmat Budi Kuswiyanto 4,3 & Sri Endah Rahayuningsih 4,3
1Universitas Padjadjaran, Bandung, Indonesia; 2Endocrinology Division, Department of Child Health, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia; 3Hasan Sadikin General Hospital, Bandung, Indonesia; 4Cardiology Division, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Introduction: Down Syndrome (DS) is a genetic disorder that has a high mortality rate and a large number of comorbidities such as hypothyroidism and heart disease. Thyroid hormones have significant effects on cardiovascular. This study aims to describe thyroid function and congenital heart defects in Down Syndrome children at dr. Hasan Sadikin General Hospital.
Methods: This is a cross-sectional study. The inclusion criteria are patients younger than 18 years of age at dr. Hasan Sadikin General Hospital Bandung during January 1st, 2015 – December 30th, 2019, clinically and confirm karyotyping diagnosed with DS, and had an examination of thyroid function and echocardiography. The data collected were sex, age, nutritional status, thyroid function, and heart abnormalities based on echocardiography.
Results: The characteristics of research subjects were male (63.6%); age 3–5 years (41.6%). There was a significant statistical difference in thyroid function (P=0.005) based on TSH levels before therapy (5.7 IU/L) and during therapy (0.7 IU/L). A total of 29% of subjects experienced tricuspid regurgitation (TR). The most common type of heart defect was PDA (30.0%).
Conclusion: This study showed the prevalence of thyroid dysfunction and heart abnormalities in patients with DS. As much as 65% of the total patients had thyroid dysfunction, and mostly hypothyroidism, with thyroid scintigraphy indicated dyshormonogenesis. The most common heart defect was PDA. Cardiac function in patients with DS and heart defects was still within normal limits.
Keywords: Down syndrome, congenital heart defects, hypothyroidism, tricuspid regurgitation
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