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60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

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The 60th ESPE Annual Meeting will now be taking place in Rome, Italy.

Rapid Free Communications

Pituitary, Neuroendocrinology and Puberty

hrp0095rfc9.1 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

The Incidence of Congenital Combined Pituitary Hormone Deficiency in Denmark - a national observational study

Kjersgaard Jakobsen Louise , Beck Jensen Rikke , Holtum Birkebæk Niels , Hansen Dorte , Rønholt Christensen Ann-Margrethe , Thybo Christesen Henrik

Background: Congenital combined pituitary hormone deficiency (cCPHD) is the loss of ≥2 pituitary hormones caused by genetic or prenatal factors.Methods: For the period 1996–2020, patients with cCPHD were identified from the Danish National Patient Registry and the registries at the four Danish hospitals approved for the management of cCPHD. Retrospective hospital file reviews were performed to validate the diagn...

hrp0095rfc9.2 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Investigation of Genes Associated with Multiple Pituitary Hormone Deficiencies via Next Generation Sequencing Technology

Pınar Öztürk Ayşe , Toksoy Güven , Baş Firdevs , Yavaş Abalı Zehra , Bagirova Gülendam , Karaman Volkan , Yıldız Melek , Aslanger Ayça , Yeşil Gözde , Poyrazoğlu Şükran , Oya Uyguner Zehra , Darendeliler Feyza

Background: Deficiency of one or more pituitary hormones, often with growth hormone (GH) deficiency, is defined as multiple pituitary hormone deficiencies (MPHD) or congenital hypopituitarism (CH). CH cases are mostly sporadic and have a prevalence of 1/3000-4000 live births. There are many known and yet unknown molecular pathways explaining the complex structure and functions of the pituitary gland. Many different gross and small sequence variants in the gene...

hrp0095rfc9.3 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Peak Serum Luteinizing Hormone Levels during Gonadotropin-Releasing Hormone Analog Test among Lean, Overweight and Obese Girls with Central Precocious Puberty

Sakornyutthadej Natee , Mahachoklertwattana Pat , Wankanit Somboon , Poomthavorn Preamrudee

Background: Elevated serum luteinizing hormone (LH) during gonadotropin-releasing hormone (GnRH) test is documented in girls with central precocious puberty (CPP). Lower LH secretion has been reported in obese girls as compared with lean girls. Few studies have addressed the effect of obesity on peak serum LH levels during GnRH test. This study aimed to determine peak serum LH levels during GnRH analog (GnRHa) test in CPP girls of different body mass index (BM...

hrp0095rfc9.4 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Association of Birth Size, Dehydroepiandrosterone Sulfate and Cardiometabolic Risk Factors in Idiopathic Central Precocious Puberty Girls

Zhang Guijiao , Yu Huan , Yu Shengxu , Luo Xiaoping , Wu Wei

Background: Early timing of puberty is associated with worse cardiometabolic health in adulthood. Furthermore, birth weight (BW) is recognized to have implications for pubertal development and cardiometabolic risk factors. The study aimed to examine the independent association between birth size, dehydroepiandrosterone sulfate (DHEAS) and cardiometabolic risk factors in idiopathic central precocious puberty (ICPP) girls.Methods:<...

hrp0095rfc9.5 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Pubertal milestones in Prader-Willi syndrome: Is there a role of genetic subtypes and MKRN3 status?

Kodytková Aneta , Dušátková Petra , Anne Amaratunga Shenali , Koloušková Stanislava , Obermannová Barbora , Pomahačová Renata , Průhová Štěpánka , Šnajderová Marta , Šumník Zdeněk , Zapletalová Jiřina , Lebl Jan

Background: Subtle phenotypic differences have previously been described among children with varied genetic subtypes of Prader-Willi syndrome (PWS) – 15q11-q13 paternal microdeletion, maternal uniparental disomy (mUPD), and rare imprinting center defects. The MKRN3 gene, located on 15q11.2, is a master regulator of pubertal initiation and is a candidate gene for abnormal pubertal development in PWS.Objective and hy...

hrp0095rfc9.6 | Pituitary, Neuroendocrinology and Puberty | ESPE2022

Craniopharyngiomas diagnosed as incidentalomas - Results of KRANIOPHARYNGEOM 2007

Boekhoff Svenja , Bison Brigitte , Eveslage Maria , Sowithayasakul Panjarat , Beckhaus Julia , Friedrich Carsten , L. Müller Hermann

Purpose: Childhood-onset craniopharyngiomas (CP) are diagnosed due to clinical symptoms (symCP) or incidentally (incCP). In childhood-onset CP, studies on history before CP diagnosis have revealed symptoms and complaints related to CP, which were documented in CP patients’ records with a median duration of 5 months prior to CP diagnosis. We investigated clinical manifestations and outcome in incCPs and symCPs.Methods:</stro...