ESPE Abstracts

ESPE Abstracts

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Previous issue | Volume 95 | ESPE2022 | Next issue

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

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The 60th ESPE Annual Meeting will now be taking place in Rome, Italy.

Top 20 Posters

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Table of contents

hrp0095t1 | Section | ESPE2022

Measurement of 11-oxo-androgens, a novel biomarker, in females with clinical signs of premature adrenarche.

Blinov Beatriz , Saenger Paul , Akerman Meredith , Gabriel Liana

Introduction: Adrenarche is characterized by the activation of androgen precursors which are released from the zona reticularis of the adrenal gland. Dehydroepiandosterone (DHEA) is a weak androgen and its conversion to slightly more potent androgens such as Dehydroepiandosterone- sulfate (DHEA-S) is thought to be responsible for the clinical signs of adrenarche. Premature adrenarche is one of the most common endocrine abnormalities causing concern among perip...
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hrp0095t2 | Section | ESPE2022

Conditional PTEN knockout in mouse osteoprogenitor cells impacts bone structure and turnover

Lorenz Judith , Kirstein Anna , Nebe Michѐle , Richter Sandy , LeDuc Diana , Kiess Wieland , Klöting-Blüher Nora , Baschant Ulrike , Garten Antje

Background: Bone development and remodeling are controlled by the phosphoinositid-3-kinase (PI3K) signaling pathway. We investigated the effects of downregulation of phosphatase and tensin homolog (Pten), a negative regulator of PI3K signaling, in osteoprogenitor cells.Methods: Femura, tibiae and bone marrow stromal cells (BMSCs) from mice with Cre-inducible Pten knockdown in cells expressing the transcription factor Ost...
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hrp0095t3 | Section | ESPE2022

Association Between Non-invasive Diagnostic Methods of Liver Fibrosis and Type 2 Diabetes in Pediatric Patients With Non-alcoholic Fatty Liver Disease

Yang Aram , Lee Ji-Eun , Kim Jinsup

Background and Purpose: The prevalence of non-alcoholic fatty liver disease (NAFLD) in children has been increasing associated with insulin resistance. However, there is a scarcity of related studies in children with NAFLD with type 2 diabetes mellitus (T2DM) compared to adults. We conducted this study to investigate the association between non-invasive diagnostic methods of liver fibrosis and T2DM in pediatric patients with NAFLD.<stron...
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hrp0095t4 | Section | ESPE2022

Does Socioeconomic Status Play a Role in Paediatric Insulin Pump Access? A Systematic Review

Nahum Andrea , Alexandrou Demitra

*Both authors contributed equally to this workBackground: Continuous Subcutaneous Insulin Infusions (CSII) or insulin pumps improve overall glycaemic control in paediatric populations. Children’s access to CSII may partly depend on socioeconomic status (SES), healthcare systems, and funding structures.Aim: The aim of our systematic review was to evaluate whether SES affects children’s a...
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hrp0095t5 | Section | ESPE2022

Genetic Variations in Early Onset Obesity: Experience from southern California

Bhangoo Amrit , Kashmiri Himala , Kadakia Sejal , Dremainep Daina

Introduction: Early onset of obesity has very severe consequences for the rest of the life which leads to morbid obesity as adults, dyslipidemia, hypertension, diabetes mellitus, sleep apnea and fatty liver disease. Recently, various genetic panels have been available and are quickly becoming a standard of care to screen children with genetic panel for obesity. However, most of these variations in ethnically diverse populations have not been extensively studie...
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hrp0095t6 | Section | ESPE2022

Circulating GDF15 Concentrations in Girls with Low Birth Weight and Precocious Pubarche: Effects of Prolonged Metformin Treatment

Díaz Marta , Carreras-Badosa Gemma , Bassols Judit , de Zegher Francis , López- Bermejo Abel , Villarroya Francesc , Ibáñez Lourdes

Background: Low birth weight (LBW) followed by a rapid postnatal catch-up in weight predisposes individuals to a central distribution of body fat, which is reverted by metformin. Growth-and-differentiation-factor-15 (GDF15) plays an important role in the regulation of energy homeostasis, reducing food intake and lowering body weight. We aimed to assess whether GDF15 concentrations are raised by long-term metformin treatment in LBW/catch-up girls with precociou...
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hrp0095t7 | Section | ESPE2022

Efficacy and safety of once-weekly somatrogon in pediatric subjects with growth hormone deficiency: lack of impact of anti-drug antibodies

Deal Cheri , Silverman Lawrence , Korth-Bradley Joan , Roland Carl , Taylor Carrie , Cara Jose , Wajnrajch Michael

Objectives: Somatrogon, a long-acting recombinant human growth hormone (GH) consisting of the amino acid sequence of human GH (hGH) and three copies of the carboxy-terminal peptide (CTP) of human chorionic gonadotropin, is approved by the EMA for treatment of children with GH deficiency (GHD). In this phase 3 study, children with GHD received either somatrogon or Genotropin. The impact of testing positive for anti-drug antibodies to somatrogon (ADA+) on the ef...
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hrp0095t8 | Section | ESPE2022

Caregiver Burden in Bardet-Biedl Syndrome: a Survey of Obesity and Hyperphagia Impacts

Forsythe Elizabeth , G. Mallya Usha , Yang Min , Huber Caroline , Lynn Cala Mary , Greatsinger Ali , Pomeroy Jeremy , M. Haqq Andrea

Background: Hyperphagia, or pathologic insatiable hunger, and early-onset obesity are prevalent clinical features of Bardet-Biedl syndrome (BBS), a rare genetic disorder. While hyperphagia and obesity have broad impacts on individuals with BBS and their caregivers, the extent of this burden is not well characterized.Methods: This multicountry cross-sectional survey of caregivers of individuals with BBS was conducted to q...
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hrp0095t9 | Section | ESPE2022

Exosomal miRNA profile in children with small for gestational age; potential biomarker for catch – up growth

Jeong Hwalrim , Hwang Il Tae

Objective: The mechanism underlying postnatal growth failure and catch up growth in small for gestational age (SGA) is poorly understood. This study attempted to identify exosomal miRNA signature associated with catch – up growth in SGA children.Methods: A total sixteen SGA children and 10 appropriate for gestational age (AGA) children included in this study. Exosomal miRNA was analyzed with next generation sequenc...
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hrp0095t10 | Section | ESPE2022

Aromatase Inhibitor (anastrazole) vs placebo delays bone age maturation in prepubertal children with Silver Russell or Prader-Willi Syndrome and pathological adrenarche

Dufourg Marie-Noëlle , Diene Gwenaelle , Cachanado Marine , Vu-Hong Thuy-Ai , Berard Laurence , Rousseau Alexendra , Soussi Nora , Pinto Graziella , Rouleau Stéphanie , Bernoux Delphine , Chalard François , Ducou Le Pointe Hubert , Lamaziere Antonin , Tauber Maite , Netchine Irène

Background: Silver Russell syndrome (SRS) is a rare imprinting disorder with prenatal and postnatal growth retardation and feeding difficulties. The main molecular causes are loss of methylation of the 11p15.5 imprinting control region (H19/IGF2) and maternal uniparental disomy of chromosome 7. Prader-Willi syndrome (PWS) is a complex neurodevelopmental imprinting disorder with neonatal muscular hypotonia, failure to thrive to insatiable appetite, sho...
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hrp0095t11 | Section | ESPE2022

Factors associated with authoimmune thyroid diseases in children with diabetes mellitus type 1

Volkava Nataliya , Solntsava Anzhalika , Aksyonova Elena

Objective: to determine risk factors of co-existing thyroid autoimmunity in children with type 1 diabetes mellitus (T1D&Mcy;).Material and Methods: 48 children with combined autoimmune pathology (45 – with T1D&Mcy; and autoimmune thyroiditis and 3 – with T1D&Mcy; and Grave’s disease) – main group, age 12.51&pm;3.57 years) and 99 patients with only T1DM (comparison group, age 11.76&pm;3.05 years) w...
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hrp0095t12 | Section | ESPE2022

Assessment of non-alcoholic fatty liver disease with non-invasive indices in adolescents with polycystic ovary syndrome

Context: Polycystic ovary syndrome (PCOS) is a complex disorder affecting women from adolescence until menopause. PCOS in adolescent years shares common features with clinical presentation in adulthood, including the adverse metabolic profile. Non-alcoholic fatty liver disease (NAFLD) is a spectrum of hepatic changes, from liver steatosis to severe inflammation and fibrinogenesis.Objective: To assess NAFLD in an adolesce...
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hrp0095t13 | Section | ESPE2022

Impact on predicted adult height and basal gonadotropin levels through triptorelin 6-month formulation in patients with central precocious puberty

Joo Yoo Eun , Yang Aram , Jun Choi Yong

Background: Triptorelin, a gonadotropin-releasing hormone (GnRH) agonist, is available as 1-, 3-, and 6-month formulation for treatment of central precocious puberty (CPP). The triptorelin 22.5mg as 6-month formulation, which has recently been approved for use in CPP and offers greater convenience to children by reducing the injection frequency, but related research is very limited. The aim of this study was to study on the impact of 6 month formulation on pre...
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hrp0095t14 | Section | ESPE2022

CCDC149: a Novel Gene Associated with Multiple Pituitary Hormone Deficiency

Rath Shoshana , Elias-Assad Ghadir , Abozaid Said , Nasser Samra Nadra , Mandel Hannah

Background: Idiopathic hypogonadotropic hypogonadism (HH) is highly genetically heterogeneous. To date, about 50 causative genes have been identified, estimated to account for up to 50% of hereditary cases. With next generation sequencing (NGS) technology now in wide clinical use, it is increasingly possible to determine the underlying genetic etiology of isolated and combined pituitary hormone deficiencies.Objective: We...
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hrp0095t15 | Section | ESPE2022

Secondary Oxidized DEHP Metabolites May Participate in the Progression from Isolated Premature Thelarche to Central Precocious Puberty or Early Puberty

Zheng Xiuxin , Su Zhe

Objective: Urine phthalic acid esters (PAEs) are one of estrogen-mimetic EDCs. Many studies have suggested that urinary phthalic acid esters (PAEs) are closely related to central precocious puberty (CPP) and isolated premature thelarche (IPT), but there is no study between urinary PAEs and the progression of IPT. This study is to explore the influence of PAEs on the progression of IPT to CPP or early puberty (EP).Methods:</strong...
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hrp0095t16 | Section | ESPE2022

The Relationship Between Leptin, Kisspeptin, Irisin, Myostatin and Omentin Levels and Fat Tissue at Puberty

Başak Polat Zeliha , Orbak Zerrin , Doneray Hakan , Ozturk Nurinnisa

Introduction: The hypothalamo-pituitary system is activated as puberty begins and GnRH release occurs as well as the synthesis of many hormones. These hormones cause changes on muscle development, body fat distribution. In this study, changes in miyostatin, irisin, kisspeptin, omentin and leptin levels and the relationship of these changes with physical properties and fat tissue were investigated.Material and Method: A t...
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hrp0095t17 | Section | ESPE2022

Impact on predicted adult height and basal gonadotropin levels through triptorelin 6-month formulation in patients with central precocious puberty

Joo Yoo Eun , Yang Aram , 아람 양

Background: Triptorelin, a gonadotropin-releasing hormone (GnRH) agonist, is available as 1-, 3-, and 6-month formulation for treatment of central precocious puberty (CPP). The triptorelin 22.5mg as 6-month formulation, which has recently been approved for use in CPP and offers greater convenience to children by reducing the injection frequency, but related research is very limited. The aim of this study was to study on the impact of 6 month formulation on pre...
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hrp0095t18 | Section | ESPE2022

SF1next study: spectrum of SF-1/NR5A1 gene variants in this large international cohort

Sommer Grit , Tack Lloyd , Cools Martine , Flück Christa , Study Group SF1next

Background: Loss-of-function variants in the NR5A1 gene are frequent causes of 46,XY differences of sex development (DSD). To date, the Human Gene Mutation Database contains 291 NR5A1 variants, most of which are missense (69%). Mouse models demonstrated the effect of loss of SF-1 on sex development, but the interactome of SF-1 is huge and an explanation for the broad phenotype is still missing. Controversies exist as: a) in vitro transactivation assays of NR5A...
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hrp0095t19 | Section | ESPE2022

Impaired gonadal function among pediatric Fanconi anemia patients following hematopoietic stem cell transplantation

Koo Jane , Rios Julie , Mehta Parinda , Davies Stella , Myers Kasiani , Howell Jonathan

Background: Gonadal dysfunction and fertility impairment are some of the many clinical manifestations described among patients with Fanconi anemia (FA). Many who receive hematopoietic stem cell transplantation (HSCT) suffer additionally from infertility due to gonadal damage from their preparative regimen. The effect of HSCT on gonadal insufficiency and fertility potential among children with FA is largely unknown.Methods:</stron...
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hrp0095t20 | Section | ESPE2022

Sensitivity to thyroid hormones and cardiometabolic risk in euthyroid obese children: a cross-sectional study.

Tropeano Angelo , Corica Domenico , Lorenza Curatola Selenia , Li Pomi Alessandra , Alibrandi Angela , Pepe Giorgia , Aversa Tommaso , Wasniewska Malgorzata

Background: The typical biochemical phenotype related to obesity, that is high serum thyrotropin (TSH) within normal range, low/normal free thyroxine (FT4) and increased free triiodothyronine (FT3) levels, can be interpreted as a resistance to thyroid hormones. It is unclear the role played by thyroid hormones in the pathogenesis of metabolic derangement associated with obesity.Aim: To investigate the association between...
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