ESPE2022 Free Communications Sex Development and Gonads (6 abstracts)
FATE-1 expression during human fetal testis development, in prepubertal boys and in infertile men
Lucie Renault 1,2 , Frederique Dijoud 1,2 , Jordan Teoli 1,2 , Herve Lejeune 1,2 , Enzo Lalli 3 , Mabrouka Doghman-Bouguerra 4,5 & Ingrid Plotton 1,2
1Hospices civils de Lyon, Lyon, France; 2Université Claude Bernard, Lyon, France; 3Inserm, Nice, France; 4Université Cote d'Azur, Nice, France; 5CNRS, Nice, France
Recently, knowledge about the molecular genetic of male infertility has increased. However, in many cases, the etiology of infertility remains unknown. The Cancer/testis antigen: Fetal and Adult Testis Expressed (FATE-1), mainly expressed in human testis has been described two decades ago for his potential role in male infertility. FATE-1 is located on the X chromosome, contains a putative SF1 binding site and is co-expressed with SRY in human fetal testis. To date, only few data are available about FATE-1 expression in developing human testis and in infertile men. In order to improve the understanding of FATE-1’s role in testicular development and infertility, we made immunohistochemistry experiments on testicular tissue from abortions from 8 to 41 gestational weeks and on infertile men who had testicular biopsy for fertility preservation or for infertility issue who consulted in the Lyon university hospital. The preliminary results from 50 fetuses and 25 biopsies of infertile men and one a pre pubertal boy showed that FATE-1 is present in the cytoplasm of the Sertoli cells expect for the pre pubertal boy. Its expression increases during fetal development. It was expressed at various degrees in infertile men. Two of the 5 patients with a non mosaic Klinefelter syndrome had an intense expression of FATE-1. They could not preserve sperm. Patients without spermatogenesis disorders had moderate expression. We describe here for the first time the expression of FATE-1 in human testis from fetal life to adulthood. We show that FATE-1 is expressed in Sertoli cells cytoplasm. The preliminary results on pre pubertal boy and infertile men seem to show various levels of FATE1 expression. These first results need additional studies to improve mechanisms understanding of expression variations.
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