ESPE Abstracts (2022) 95 LB21

ESPE2022 Poster Category 1 Late Breaking (25 abstracts)

Glucose levels are not the same for everyone: A real-world big data study evaluating glucose levels by sex and age among children

Carmit Avnon Ziv 1,2 , Tamar Banon 2 , Amir BenTov 3,2 , Adi Aeurbach 1,2 , Harry Hirsch 1,2 & Floris Levy Khademi 1

1Shaare Zedek Medical Center, Jerusalem, Israel; 2Maccabi Healthcare Services, Tel Aviv, Israel; 3Sackler School of Medicine, Tel Aviv, Israel

Purpose: Understanding the normal range of laboratory values as pertained to different age groups and males or females is paramount in health care delivery. We aimed to assess the distribution of glucose levels by age and sex in the general population of children using a large-scale population-based cohort.

Methods: A retrospective study with real-world de-identified data from a large, state mandated health fund in Israel among children aged 2 to 18 years old between 2006 and 2019. Age, sex, and BMI differences in mean glucose levels were evaluated using 3-way Anova.

Results: Study included 130,170 blood samples from 117,411 children, 53.3% were female. After adjusting for age boys had higher glucose levels than girls, with a mean of 89.21 ±8.66 mg/dL vs. 87.59 ±8.35 (P<0.001). Compared to the 15 to 18 year-olds (88.49 mg/dl ±7.63), 2 to 5 year-olds had lower glucose levels (84.19 ±10.65, (P<0.001)), 11 to 14 year-olds had higher glucose (90.40 ±7.42 (P<0.001)) and 6 to 10 year-olds showed no difference (88.45 ±8.25). Among our cohort, 33.0% (n=42,991) had a BMI percentile record the same year as their glucose test result. There was a weak yet significant positive association between blood glucose levels and BMI (Pearson coefficient <0.1).

Conclusions: Our large cohort indicates that boys have higher glucose levels than girls, as do adolescents compared to younger children. This finding is important for the delivery of adequate health care, screening for illness and avoiding unnecessary investigations and tests.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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