ESPE2022 Poster Category 1 Growth and Syndromes (85 abstracts)
Background and Objectives: In the patients with Turner syndrome (TS), the risk of hypertension is higher in childhood and adulthood. The aim of the study was to retrospectively analyze 24-hour ambulatory blood pressure monitoring (ABPM) in children and adolescents with TS and its related factors.
Materials and Methods: A retrospective study was conducted involving TS patients admitted to our pediatric endocrine specialist clinics, the First Affiliated Hospital, Sun Yat-sen University, between January 2012 and December 2018. All patients completed anthropometric measurement, 24-hour ABPM, testing of cholesterol (CHOL), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), blood urea nitrogen (BUN), creatinine (Cr), fasting glucose, fasting insulin, estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and progesterone (P), testosterone (T), 8 am cortisol, echocardiography and abdominal ultrasound.
Results: A total of 27 patients with TS were identified，ranging in age from 7 to 23 years old (13.41±4.88), and 9 patients with ambulatory hypertension were detected by 24-hour ABPM. Among these 9 patients, 1 patient had elevated mean daytime blood pressure (BP), 4 patients had elevated mean nighttime BP, and 4 patients had elevated mean daytime and nighttime BP. The circadian rhythm with dipper BP pattern accounted for 33.3%, non-dippers BP pattern accounted for 66.7% of which 4 patients were reverse-dippers. Twenty-one patients had a decrease more than 10% of pulse rate at night. Among 27 TS patients, 2 patients had heart disease (7.4%) and 3 patients had horseshoe kidney (11.1%). The mean diastolic blood pressure (DBP) of TS patients was negatively correlated with HDL-c (P< 0.05). No correlation was found between mean systolic blood pressure (SBP) or DBP and E2 and T (P > 0.05). The decrease rate of SBP at nighttime in TS patients was negatively correlated with FSH, LH, PRL and T (all P< 0.05). The decrease rate of DBP at nighttime was negatively correlated with FSH and LH (all P<0.05). FSH, LH and PRL of the non-dippers BP group were higher than those of the dippers BP group (all P<0.05).
Conclusion: In this study, the detection rate of ambulatory hypertension in TS patients was relatively high, among which non-dippers BP pattern accounted for the majority. Low HDL-c level might be one of the causes of hypertension in Turner syndrome. Sex hormone levels in TS patients might further affect BP, leading to the occurrence of hypertension.
15 Sep 2022 - 17 Sep 2022