ESPE2022 Poster Category 1 Pituitary, Neuroendocrinology and Puberty (77 abstracts)
The Effect of Metformin on the Onset of Menarche and The Final Height of Obese Girls
Shadab Salehpour 1,2 , Fatemeh Kalantari 3 & Somayeh Setavand 3
1Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Clinical Research Development Centre of Loghman Hakim Hospital, Tehran, Iran; 3SBMU, Tehran, Iran
Background/aims: Obese girls experience precocious puberty which could influence their final height. We studied the effect of metformin on their body weight, final height, onset of menarche, and bone age.
Methods: In a prospective study, 63 obese girls aged between 8 -13 years old were treated with metformin (500-1000 mg/daily and compared with control at the outpatient pediatric endocrine clinic of Loghman Hakim Hospital in Tehran for 5 years.
Results: Metformin differed control in significantly decreasing body weight, delaying menarche and bone age progress, and increasing final height.
Conclusion: Metformin could decrease the body weight, delay the menarche and improve the final height in the obese girls.
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