ESPE2022 Poster Category 1 Diabetes and Insulin (86 abstracts)
Analysis of peripheral nerve conduction function and its influencing factors in children and adolescents with type 1 diabetes mellitus
Lina Zhang , Liyang Liang , Qingfang Song , Zhe Meng , Zulin Liu , Lele Hou , Zhanwen He & Siqi Huang
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen Memorial University, Guangzhou, China
Objective: To explore the status and the main influencing factors of peripheral nerve conduction dysfunction in Chinese children and adolescents with type 1 diabetes mellitus (T1DM).
Methods: Nerve electrophysiological indicators including amplitude, latency and conduction velocity of median nerve, ulnar nerve, superficial peroneal nerve, sural nerve, common peroneal nerve and tibial nerve were collected, and the results of the last follow-up examination were included in statistical analysis.
Results: The median age of 69 T1DM patients was 10.75 years. The rate of abnormal nerve conduction examination was 43.48% (30/69), and the rate of chief complaint of paresthesia was 37.68% (26/69). A total of 621 peripheral nerves were detected, and 12.24% was abnormal in all, 11.23% in motor nerve, 13.04% in sensory nerve, 10.87% in the upper limb and 13.33% in the lower limb. The abnormal rates of common peroneal nerve, median nerve, sural nerve, superficial peroneal nerve, tibial nerve and ulnar nerve were 18.84%, 17.39%, 14.49%, 7.25%, 5.80% and 5.07% respectively. The abnormal nerve conduction examination group had higher HbA1c, triglyceride, low density lipoprotein cholesterol, CD4+/CD8+T cells, neutrophil to lymphocyte ratio (NLR), longer course of disease and lower C-peptide and 25-hydroxyvitamin D levels. The course of disease and NLR were risk factors for abnormal peripheral nerve conduction in T1DM.
Conclusion: The abnormal nerve conduction function of T1DM is very common in children and adolescents. Selective NCS examination is helpful to improve the sensitivity of nerve conduction examination in diagnosing DPN.
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