ESPE2022 Poster Category 1 Diabetes and Insulin (86 abstracts)
The Metabolic Syndrome is frequent in Children and Adolescents with Type 1 Diabetes Compared to Healthy Controls
Freja Barrett Mørk 1,2 , Jens Otto Broby Madsen 2 , Kasper Ascanius Pilgaard 1,2 , Andreas Kryger Jensen 3 , Heidi Klakk 4,5 , Jakob Tarp 6 , Anna Bugge 7 , Malene Heidemann 8,9 , Gerrit Van Hall 10,11 , Flemming Pociot 1,12 , Niels Wedderkopp 13,14 & Jesper Johannesen 1,2,12
1Steno Diabetes Center Copenhagen, Department of Clinical Research, Herlev, Denmark; 2Herlev and Gentofte Hospital, Department of Pediatrics and Adolescent Medicine, Herlev, Denmark; 3University of Copenhagen, Department of Public Health, Copenhagen, Denmark; 4University College South, Center for Applied Health Science, Haderslev, Denmark; 5University of Southern Denmark, Research Unit for Exercise Epidemiology, Odense, Denmark; 6Aarhus University, Department of Clinical Epidemiology, Aarhus, Denmark; 7University College Copenhagen, Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, Copenhagen, Denmark; 8Odense University Hospital, Hans Christian Andersen Children's Hospital, Odense, Denmark; 9University of Southern Denmark, Clinical Institute, Odense, Denmark; 10University of Copenhagen, Department of Biomedical Sciences, Copenhagen, Denmark; 11Rigshospitalet, Department of Clinical Biochemistry, Copenhagen, Denmark; 12University of Copenhagen, Department of Clinical Medicine, Copenhagen, Denmark; 13Odense University Hospital, Institute of Clinical Research, Odense, Denmark; 14University of Southern Denmark, Department of Clinical Research, Odense, Denmark
Background: There is a rise in overweight and obesity among children and adolescents with type 1 diabetes (T1D) in parallel with a rise in the metabolic syndrome (MS) among children and adolescents in general.
Objective: The aim of the study was to describe the prevalence and characteristics of the MS in children and adolescents with T1D compared to their healthy counterparts.
Design and Setting: The study includes two Danish cohorts; (i) the Copenhagen T1D cross sectional cohort 2016 of 277 children and adolescents with T1D that attend the pediatric outpatient clinic at a large hospital in greater Copenhagen and (ii) the a control cohort from the CHAMPS-study DK which is a population-based cohort study of Danish children and adolescents. Participants were categorized to have MS if at least two of the following criteria were met: (i) systolic and/or diastolic blood pressure ≥ 90th percentile, (ii) waist circumference ≥ 90th percentile, and (iii) triglyceride ≥ 90th percentile and/or HDL ≤ 10th percentile. In according to consensus in studies with participants with T1D, the definition does not include blood glucose levels.
Results: The prevalence of children with MS in the T1D cohort was higher than in the control cohort (13% vs. 7%; P=0.002). In addition, participants with T1D had MS at a lower BMI z- score (z-score=0.90) compared to the control cohort (z-score: 1.43; P<0.001) and lower waist circumference z-score (z-score=1.51) than participants with MS from the control cohort (z-score=2.02; P<0.001). Participants with MS were younger than the other T1D participants (median 12.8 [9.9,14.8] vs median 14.6 [11.2,16.9] years, P=0.006) and had a higher HbA1c adjusted for sex and age (P=0.003).
Conclusions: Children and adolescents with T1D have an increased risk of MS compared to healthy controls; hence clinicians and caretakers should consider early prevention and health promotion strategies.
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