ESPE2022 Poster Category 1 Fetal, Neonatal Endocrinology and Metabolism (30 abstracts)
Background: Very low birth weight (VLBW) infants tend to have slower postnatal growth than the fetuses of the same gestational age (GA)1. Higher nutrient intake and better early growth are associated with better neurocognitive outcomes; excessive nutrient intakes may lead to metabolic consequences. Nutrient intakes for optimal growth, body composition and neurodevelopment are not known.
Objectives: To assess growth and neurodevelopment of VLBW infants during the first year of life and its relationship with early nutrition.
Methods: 120 VLBW infants were divided into 2 groups: extremely preterm (EP, <28 weeks) and very/moderately preterm (VP). 92 infants completed 12 months follow-up. Nutrient intake was calculated for the first 4 weeks. Growth (weight, length, and head circumference (HC)) was measured weekly until discharge, and at 3,6,9,12 months corrected GA (CGA) and related to healthy infants2. Body composition was assessed at discharge by dual X-ray absorptiometry (DXA). Neurodevelopment was assessed at 12 months using Bayley-II.
Results: At birth, weight
Conclusion: Weight, length, and HC growth patterns are different in GA groups and should be considered when choosing feeding strategies. Nutrient intake should be balanced between improving neurodevelopmental outcomes and potential risk of metabolic syndromes.
1. Brinkis R et al Nutrients. 2022; 14: 1181
2. Niklasson A & Albertsson-Wikland K. BMCPediatr. 2008; 8: 8
15 Sep 2022 - 17 Sep 2022