ESPE2022 Poster Category 1 Fetal, Neonatal Endocrinology and Metabolism (30 abstracts)
Impaired renal clearance among Swedish adolescents born preterm
Carin Skogastierna 1 , Anders Elfvin 1,2 , Sverker Hansson 3 , Per Magnusson 4 & Diana Swolin-Eide 5,6
1Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden; 2Region Västra Götaland, Sahlgrenska University Hospital, Department of Pediatrics, Gothenburg, Sweden; 3Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 4Department of Clinical Chemistry, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; 5Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Gothenburg, Sweden; 6Region Västra Götaland, Sahlgrenska University Hospital, Department of Pediatrics, Gothenburg, Sweden, Gothenburg, Sweden
Aim: To determine whether adolescents born before 28 gestational weeks have an increased risk for renal impairment.
Methods: Swedish infants, born before 28 gestational weeks in 2001 and 2002, were identified from a local register. A total of 16 children, 12 females and 4 males, were examined at 16–17 years of age with 51Cr-EDTA clearance. A comparison group (n=26) was used.
Results: Most study participants (n = 13) had normal blood pressure; one individual had hypertension stage 1. All study participants had results within the reference interval for ionized calcium, parathyroid hormone, intact fibroblast growth factor-23, and for urinary albumin-to-creatinine ratio. Four out of 16 participants (25%) had a 51Cr-EDTA clearance less than 90 mL/min/1.73m2, indicating a reduced kidney function. However, 13 participants (81%) had an estimated glomerular filtration rate below 90 mL/min/1.73m2. Five study participants (31%) were referred for further investigations. We found a significant difference for the measured 51Cr-EDTA clearance values between the study and comparison groups, P=0.0012.
Conclusion: Swedish children born before 28 gestational weeks have an increased risk of renal impairment later in life, suggesting that the kidney function in these individuals should be assessed, at least once, during adolescence.
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