ESPE Abstracts (2022) 95 P1-331

ESPE2022 Poster Category 1 Growth and Syndromes (85 abstracts)

Prevalence of Obesity from birth to 3 years of age in infants born large for date (LGA): Infants with weight for age (WAZ) catch down vs those without catch down during the first year of life

Fawzia Alyafei , Ashraf Soliman , Saleha Abbsi , Fatima Alkhori , Nada Alaaraj , Shayma Ahmed , Noor Hamed & Hamdy Ali 1


Hamad General Hospital, Doha, Qatar

Introduction: Infants whose weight is > the 90th percentile for gestational age are classified as large for gestational age (LGA). Catch-up and catch-down growth can be defined as an increase or decrease in WAZ by > 0.67 SD respectively during the infantile period. It was suggested that in LGA rapid catch-up and/or no catch-down during infancy may be associated with the development of overweight (OW) and obesity (OB) during childhood.

Aim of the Study: We evaluated the prevalence of OW and OB in a cohort of infants (n = 87) born LGA (birth weight (wt) > 4 kg) from birth to age 3 years. We compared the prevalence of OW and OB in those who had significant catch down > 0.67 SD during infancy to those who did not have catch down.

Results: In LGA infants, the prevalence of obesity (WAZ > 2) increased markedly from 24% at the end of their first year to 39% and 42.5% at the end of the second and third years of life respectively. More than half of LGA children showed catch-down growth during infancy. Those with significant catch-down during infancy had a lower tendency to be OW and OB when they grow up. Compared to those without postnatal catch-down growth.

Table: Effect of rapid WAZ catch down during 6 and 12 months on the prevalence of OW and OB at 3 years of age
  number WLZ >2 <3 WLZ >3 Ob + OW
With Catch down >-0.67 WAZ at 6/12 45/87 11.4% 0 11.4%*
With Catch down >-0.67 WAZ at 1 year 32/87 8.3%* 0* 8.3%**
Without Catch down >-0.67 WAZ at 6/12 40/87 18.2% 21.2% 39%
Without Catch down >-0.67 WAZ at 1 year 56/87 22.5% 20% 42.5%
P value catch down vs no catch down * < 0.05, ** <0.001

Conclusion: Infants born LGA had a significant tendency to be OW or OB during early childhood. Those who had caught down in WAZ during the first year had a lower prevalence of OW and OB at 2 years of age. (table 1)

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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