ESPE Abstracts (2022) 95 P1-425


1Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan; 2Department of Pediatrics, Iizuka Hospital, Iizuka, Japan; 3Chemicals Evaluation and Research Institute, Japan (CERI), Kurume, Japan; 4Department of Gynecology and Obstetrics, Iizuka Hospital, Iizuka, Japan; 5Department of Gynecology and Obstetrics, Kurume University School of Medicine, Kurume, Japan

Introduction: Breast milk is a perfect food, but it can be deficient in vitamin D. In the Danish study, vitamin D was correlated in mothers, breast milk and not in breast milk and infants. We investigated the correlation between mother, breast milk, and infants vitamin D levels in Japan.

Materials and Methods: This study included 84 pairs of mothers and 2-week-old infants born at the Iizuka Hospital and Vitamin D including D2, D3, 25(OH)D2 and 25(OH)D3 in mothers, foremilk, hindmilk and infants were determined by LC-MS/MS. We defined D2+D3 as VD and 25(OH)D2+25(OH)D3 as VDOH.

Results: We observed seasonal variation in VD and VDOH, with high summer and low winter levels in mothers and breast milk. Both VD and VDOH showed a correlation between mothers, breast milk and infants. However, because infants VD and VDOH were correlated with the proportion of formula, analysis of 24 pairs of fully breastfed infants showed no correlation between breast milk and infants. We found that there was a mothers/breast milk and mothers/infant VD and VDOH correlation, but there was no breast milk/infants VD and VDOH correlation as previously reported.

Discussion: It may appear that the correlation between breast milk and infants is not so small as to be due to the abundance of VD and VDOH in breast milk.

Conclusions: In Japan, infants vitamin D was dependent on the proportion of fomula, and there was no correlation between breast milk and infants vitamin D.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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