Aim: 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME) is a lipokine secreted from brown adipose tissue, and it is shown to have positive effects on dyslipidemia. Acute exercise have been shown to lead to an increase in its secretion. It was aimed to investigate the relation of 12,13-diHOME with obesity, exercise and dyslipidemia for the first time in the adolescent age group.
Methods: This is a prospective study including a total of 28 male adolescents with obesity and the same number age-matched healthy normal-weight male controls. Fasting serum glucose, insulin, lipid and 12,13-diHOME levels were measured. Cardiopulmonary exercise testing was performed in all subjects stress test treadmill 3 days in a row. Peak oxygen consumption (Peak VO2) and anaerobic threshold heart rate (ATHR) were measured.
Results: Adolescents with obesity had lower 12,13-diHOME levels than normal-weight adolescents both before and after acute exercise (P=0.025 and P=0,019, respectively), and after acute exercise, 12,13-diHOME levels increased significantly in both groups. 12,13-diHOME levels negatively correlated with triglyceride, total cholesterol, LDL-C, and positively correlated with HDL-C. Also, peakVO2 and ATHR levels showed positive correlation with 12,13-diHOME levels.
Conclusion: 12,13-diHOME levels were found to be lower in adolescents with obesity than normal-weight adolescents and increase with acute exercise regardless of body mass index. Also, the close relation of this molecule with dyslipidemia in addition to obesity suggests that it has an important role in the pathogenesis of these disorders and that 12,13-diHOME may be a promising therapeutic agent for dyslipidemia and obesity in the future.
15 Sep 2022 - 17 Sep 2022