Laboratory evidence of hyperaldosteronism is common in patients with kidney stones - a retrospective single-center analysis

Ashraf Soliman; Hamdy Ali; Nazla Mahmoud; Maya Itani; Haytham Yassen

P1-518

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ESPE Abstracts (2022) 95 P1-518

ESPE2022 Poster Category 1 Growth and Syndromes (85 abstracts)

Variable post-operative growth pattern in infants with transposition of great arteries (TGA) after neonatal arterial switch operation

Ashraf Soliman ¹ , Hamdy Ali ¹ , Nazla Mahmoud ¹ , Maya Itani ¹ & Haytham Yassen ²

Author affiliations

¹Hamad General Hospital, Doha, Qatar; ²Sidra Medicine, Doha, Qatar

The arterial switch operation (ASO) represents a remarkable success in the treatment of cyanotic congenital heart disease, with survival rates approaching 100%. The effect of infantile deep hypothermic circulatory arrest and hypoxia on post-operative linear growth is not studied. Growth data were recorded and analyzed in 12 infants with d-TGA who underwent switch operation (anatomical correction) in the early neonatal period for 18 months.

Results: After the operation, 5/12 crossed down Length centiles by 1 SD or more and 1 infant crossed up centiles > 1SD. 6/12 crossed down WAZ by 1 SD or more during the 18 months after surgery. 18 months after surgery 2 infants had WAZ< -1.5. One infant had HCZ <-2 at birth which improved markedly to -0.28 during 18 months after surgery. HCZ increased by 1 SDS or more in 3/12 infants after surgery and decreased by 1SD or more in 4/12 after surgery. None of the children had HCZ < -2 at 18 months of age. Weight/Length Z score (WLZ) was < -2 in 5/12 at birth and only in one infant 18 months after surgery. WLZ improved > 1SD in 7/12 of infants and decreased by 1 SD in one infant after surgery.

Table: Growth of infants with TGA 18 months after early neonatal corrective surgery
patients	LAZ1	LAZ2	WAZ1	WAZ2	HC Z1	HC Z2	WLZ1	WLZ2
1	2.08	1.18	0.87	2.53	0.35	0.07	-1.58	2.57
2	-0.03	-1.03	-0.16	-0.13	-1.24	-0.18	-0.37	0.57
3	0.1	-0.5	-1.1	1.05	0.02	0.75	-2.15	1.42
4	-0.17	-0.85	-0.43	-1.75	-1.67	-0.71	-0.63	-1.69
5	-0.71	-1.14	0.05	-1.67	0.45	-0.67	0.8	-1.53
6	-0.12	-1.73	-1.4	-3.27	-1.24	-1.93	-2.52	-2.45
7	0.22	1.39	0.92	-0.1	1.06	0.7	1.02	-1.22
8	0.93	-0.23	-0.14	-0.05	0.35	-0.69	-1.94	0.08
9	1.44	-0.65	-0.31	-1.27	-0.82	-2.13	-2.29	-1.33
10	2.61	1.89	2.01	0.51	1.14	-0.11	-0.46	-0.52
11	0.5	0.25	-0.04	0.53	0.35	0.15	-0.87	0.54
12	-2.14	0.06	-3.76	0.22	-3.61	-0.28	-4.35	0.24
Mean	0.39	-0.11	-0.29	-0.28	-0.41	-0.42	-1.28	-0.28
SD	1.27	1.11	1.42	1.52	1.37	0.89	1.51	1.45

In conclusion Anatomical correction for d-TGA in the early neonatal period resulted in variable patterns of growth. The WLZ improved in most infants. None of the infants had LSDS or HCZ < -2 at 18 months. These data indicated acceptable linear growth, weight gain, and head growth in these infants.