ESPE2022 Poster Category 1 Growth and Syndromes (85 abstracts)
Two years of Postnatal linear and head growth of term Infants Born Large for Date (LGA): Those who had infantile Length Z score (LAZ) and/or head circumference Z score (HCZ) catch down vs those without catch down.
Fawzia Alyafei , Ashraf Soliman , Saleha Abbsi , Fatima Alkhori , Hamdy Ali , Nada Alaaraj , Noor Hamed & Shayma Ahmed
Hamad General Hospital, Doha, Qatar
Introduction: Large for date (LGA) infants may have a higher tendency to become obese and tall. Catch-up and/or catch-down in linear growth, defined as an increase or decrease in length for age Z score (LAZ) by > 0.67 SD during the infantile period, may affect this tendency. Additionally, head circumference is well correlated with brain growth.
Aim: We evaluated the prevalence of tall stature (LAZ > 1 and> 2) and large head (HCZ > 1 and >2) in a cohort of infants (n = 87) born large-for-gestational-age at age 2 years. We compared the prevalence of tall stature and large head in those who had significant catch down > - 0.67 SD during infancy to those who did not have catch down.
Results: The prevalence of tall stature (LAZ > 1 and > 2) was significantly higher in the LGA group who did not have significant catch-down during infancy. (Table 1) The prevalence of large head (HCZ > 1 and > 2) was higher in LGA children who did not have significant catch-down during infancy. (Table 2)
| number | LTZ >1 <2 | LTZ >2 | LT>1 | |
| With Catch down >-0.67 WAZ at 6/12 | 45/87 | 10/36 27.8% |
3/36 8.3% |
13/36 36% |
| With Catch down >-0.67 WAZ at 1 year | 32/87 | 6/25 24% |
1/25 4% |
7/25 28% |
| Without Catch down >-0.67 WAZ at 6/12 | 40/87 | 11/39 28.2% |
10/39 25% |
21/39 53.8% |
| Without Catch down >-0.67 WAZ at 1 year | 56/87 | 18/38 47.4% |
12/38 31.6% |
30/38 78% |
P value catch down vs no catch down * < 0.05, ** <0.001 |
| number | HCZ >1 <2 | HCZ >2 | HCZ>1 | |
| With Catch down >-0.67 WAZ at 6/12 | 45/87 | 10/31 32.3% |
2/31 6.5% |
12/31 38.7% |
| With Catch down >-0.67 WAZ at 1 year | 32/87 | 7/55 12.7% |
3/55 5.5% |
10/55 18.2% |
| Without Catch down >-0.67 WAZ at 6/12 | 40/87 | 11/25 44% |
7/25 28% |
18/25 72% |
| Without Catch down >-0.67 WAZ at 1 year | 56/87 | 16/55 29.1% |
7/55 12.7% |
23/55 41.8% |
Conclusion: According to our data, term LGA infants with no catch-down growth had an increased incidence of tall stature and large head size compared to those with significant catch-down growth. A large percentage of LGA infants have relatively large heads at 2 years of age.
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