ESPE Abstracts (2022) 95 P1-576

ESPE2022 Poster Category 1 Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology (56 abstracts)

Relationship between environmental effects and metabolic characteristics of partial and central precocious puberty in girls: Understanding pathogenesis and identifying specific biomarkers

Jing Chen 1 , Jinxia Wu 2 , Rong Huang 1 , Hongwei Zhu 3 , Lin Che 4 , Yanyan Lin 1 , Yajie Chang 2 , Guiping Shen 2 & Jianghua Feng 2


1Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China; 2Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, China; 3The First Affiliated Hospital of Bengbu Medical College, Bengbu, China; 4Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, China

Background: The differential diagnosis of partial precocious puberty (PPP) and central precocious puberty (CPP) is vital to the prompt intervention and administration, but their specific biomarkers are still unavailable. The potential harmful effects of environmental factors on children's growth and development attract great concern and require urgent investigation.

Objective: The metabolic differences and connection of PPP and CPP girls were investigated to elucidate their respective pathogenesis and screen the serum-specific biomarkers for early diagnosis. The relationship between serum perfluorinated compounds (PFCs), clinical indicators and specific biomarker was explored to reveal the environmental consequences on the occurrence of precocious puberty (PP).

Methods: A nuclear magnetic resonance (NMR)-based comparative metabolomic analysis was performed on serum from 146 PP girls. The metabolic characteristics of PPP and CPP were derived from the uni- and multi-variate statistic and metabolic network analyses. LC-MS/MS was used to measure the serum PFCs of PPP and CPP, and correlation analysis was performed to deeply explore the relationships between PFCs, clinical indicators and specific biomarkers in PPP and CPP girls.

Results: Eight and eleven serum-specific potential biomarkers were screened for PPP and CPP girls, respectively, and their sensitivity and specificity were investigated by random forest-based ROC curve. The disturbed pyruvate metabolism and butyrate metabolism were shared by PPP and CPP. PFHpA and PFHA were statistically different between PPP and CPP girls. The correlations between PFCs, clinical indicators and the specific biomarkers revealed the different pathogenesis of CPP and PPP girls and their differential responses to environmental effects.

Conclusions: Formate, ethanol, and 3-hydroxybutyrate probably can be used as early diagnostic indicators for PP girls. The serum-specific biomarkers could facilitate the differential diagnosis of CPP and PPP girls. PFCs may be involved in the occurrence and development of PP mainly by disturbing the endocrine homeostasis of girls.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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