ESPE Abstracts (2022) 95 P1-75

ESPE2022 Poster Category 1 Fat, Metabolism and Obesity (73 abstracts)

The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents

Ji Hyun Kim 1 , Jong Bin Lee 2 & Jung Sub Lim 3


1Dongguk University Ilsan Hospital, Goyang, Republic of South Korea; 2Konyang University Hospital, Daejeon, Republic of South Korea; 3Korea Cancer Center Hospital, Seoul, Republic of South Korea

Purpose: Metabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the association between hsCRP and MetS and its components in Korean children and adolescents.

Methods: We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2017. This study defined MetS and its components using the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria.

Results: The mean hsCRP level was 0.86 ± 1.57 mg/dL (median and interquartile range: 0.37 and 0.43 mg/dL). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/dl, P<0.001). With the higher quartile value of hsCRP, the prevalence of MetS increased. Compared to the lowest quartile, the odds ratio (ORs) for having MetS in the highest quartile was 7.34 (3.07-17.55), adjusting for age and sex. In the top quartile of hsCRP, the risk of having abdominal obesity and low HDL was high after adjusting for age, sex, and other components of the MetS. Additionally, the ORs for having prediabetes (HbA1c ≥5.7%) in the highest quartile was 2.70.

Conclusions: Serum hsCRP level is positively associated with MetS and prediabetes even using NCEP-ATP III criteria. Among the MetS components, abdominal obesity and low HDL were highly correlated with hsCRP in Korean children and adolescents.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.