ESPE2022 Poster Category 1 Fetal, Neonatal Endocrinology and Metabolism (30 abstracts)
Introduction and objectives: Imprinted genes have been broadly related to prenatal growth regulation. PEG10 is a maternally imprinted gene involved in cellular proliferation that is mainly expressed in the placenta and in some adult tissues. In mice, mutations in this gene have been related to growth restriction of both the embryo and the placenta. Nevertheless, its role in postnatal growth has not yet been established. We aimed to study prospectively the relationship between PEG10 methylation in the placenta and postnatal growth in children at 6 years of age.
Subjects and methods: The study population consisted of a cohort of pregnant women and their newborn infants who were followed from birth until 6 years of age. All mothers and newborns were healthy, with term pregnancies and infants’ weights appropriate for gestational age. PEG10 methylation levels were analyzed by pyrosequencing in 104 placental samples. Associations between methylation percentage of PEG10 and offspring growth, anthropometric and metabolic parameters in the offspring from birth to 6 years of age were sought by correlation analyses, with adjustment for cofounding variables in multiple regression analyses.
Results: PEG10 methylation correlated with anthropometric parameters in the infants during the first year of life and at follow-up at 6 years of age. Specifically, PEG10 methylation correlated negatively with ponderal index (PI) at 2 and 4 months of age (P=0.002 to P=0.005). At follow-up at 6 years of age, PEG10 methylation correlated negatively with body mass index (BMI) and with weight and BMI SDS (z-score) changes from birth to 6 years of age (P=0.04 to P=0.005). After adjusting for cofounding variables, placental PEG10 methylation remained significantly associated with PI at 2 and 4 months, and with weight and BMI SDS (z-score) changes from birth to 6 years of age (β from -0.382 to -0.235, all P<0.02).
Conclusions: PEG10 methylation may have an important role in offspring development, by regulating postnatal growth during the first years of life. Specifically, PEG10 methylation may affect weight gain early in life, ultimately decreasing the risk of developing obesity in children.
15 Sep 2022 - 17 Sep 2022