ESPE Abstracts

Introduction: Obesity is a rapidly growing health problem, with increasing worldwide prevalence. Obesity is accompanied by numerous metabolic and endocrine dysregulation. Thyroid dysfunction is one of the many metabolic aberrations that are associated with obesity. Thyroid dysfunction can be related to obesity, insulin resistance, and dyslipidemia. We aimed to study the thyroid function in children and adolescents with obesity and the metabolic parameters.

Methods: A total of 60 children with BMI over 95th percentile for their age and sex, were included in the obesity group, and 52 healthy children without obesity (BMI less than 85th percentile) were enrolled in the control group. Thyroid function tests including TSH, T4, and T3 were measured. The levels of insulin, fasting blood sugar (FBS), cholesterol, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and triglyceride (TG) of the patients were also assessed.

Results: Thyroid function tests were not significantly different between the obesity and the control groups. Additionally, they did not have any significant correlation with the metabolic parameters, neither in the subjects with obesity nor in the control subjects.

Conclusion: Despite the central role of thyroid hormones in the modulation of metabolism, their levels are not influenced by the obesity status