ESPE2022 Poster Category 2 Fetal, Neonatal Endocrinology and Metabolism (16 abstracts)
Placental Weight and their relation to Infant Birth weight and Gender, Gestational Age, and Maternal Age: (A Population-Based Retrospective Data Analysis (n = 80722)
Fawzia Alyafei , Mai Al-qubasi , Ashraf Soliman , Hamdy Ali , Tawa Olukade , Mohamed Alturk , Nada Alaaraj , Noor Hamed & Shayma Ahmed
Hamad General Hospital, Doha, Qatar
Introduction: Many potential factors can affect or be influenced by placental size. These include gestational age, maternal age, race, socioeconomic status, and gender of the baby.
Aim: We investigated the possible association/s between placental weight on the one hand and birth weight, gestational age, maternal age, and gender of the baby in a large cohort of newborns (n = 80722)
Methods: This population-based analysis comprised of a 4-year cohort data (January 2016 to December 2019) for births conducted in all HMC hospitals. These hospitals account for about 90% of all births in the country. The inclusion criterion for this analysis was term singleton live births, 37+0 to 42+6 weeks gestation (sample size = 80722).). Pearson correlation coefficients explored the relationship between placental weight and other variables. The effect point estimates with 95% CI and R2 were obtained.
Results: The placental weight continued to increase through 41 weeks' gestation in all the studied newborns. The mean placental weights were significantly heavier in boys vs girls. Small, appropriate, and large for date infants demonstrated a consistent increase in placental size until 41 weeks of gestation with a mild but significant decrease in the 42nd week. Placental weight was significantly correlated with birth weight (r = 0.596, P< 0.001) and gestational age (r = 0.15, P<0.001). (Table 2) Placental weight accounted for 43.4% of the explained variability in birth weight. Birth weight was correlated significantly with the gestational age (r = 0.324, P<0.001) and decreased significantly after maternal age of 35 years.
| Gestational age (wk) | Mean Pl wt (g) | SD |
| 37.00 | 629.95 | 115.51 |
| 38.00 | 648.66 | 108.61 |
| 39.00 | 661.39 | 101.22 |
| 40.00 | 677.34 | 95.14 |
| 41.00 | 687.74 | 98.08 |
| 42.00 | 672.69 | 103.56 |
| Birth wt. | Placenta wt. | Gestation age | Maternal age | |
| Birth wt. | 1.000 | |||
| Placenta wt. | 0.597* | 1.00 | ||
| Gestation age | 0.324* | 0.153* | 1.00 | |
| Maternal age | 0.07 | 0.04 | -0.12 | 1.00 |
| *P< 0.01 | ||||
Conclusions: Reference standards of our large national cohort were achieved. Newborn infants demonstrated a consistent increase in placental weight until 41 weeks of gestation with a mild but significant decrease in the 42nd week.
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