ESPE Abstracts (2022) 95 P2-154

ESPE2022 Poster Category 2 GH and IGFs (14 abstracts)

Predictive Factors of Adult Height After 2 Years of GH Replacement Therapy in Children with Growth Hormone Deficiency (GHD)

Concetta Mastromauro 1 , Nella Polidori 1 , Cristina Gentile 1 , Francesco Chiarelli 1,2 , Angelika Mohn 1,2 & Cosimo Giannini 1,2

1Department of Pediatrics, Chieti, Italy; 2University of Chieti, Chieti, Italy

Introduction: Growth Hormone Deficiency (GHD) represents the most common hormone deficiency during childhood accounting for 3% of causes of short stature. Although growth hormone (GH) replacement therapy is available, several studies have shown a different response in terms of height. Therefore, some reports have tried to characterize predictive factors able to define growth gain during treatment.

Objective: Therefore, the purpose of this study was to evaluate the possible predictive factors of change in height SDS in GHD children after at least 2 years of GH therapy.

Results: Data from 77 normal weight children and adolescents with GHD (age: 12.1±2.7 years; Girls/Boys: 24/53) have been included in the study. A complete anthropometric measures (weight, height, BMI, target height, bone age) and biochemical factors (IGF-1, lipid profile, glucose metabolism) at baseline and at follow up were evaluated. A Spearman correlation between height SDS at follow up and the main variables of interest at baseline was performed. A significant difference between baseline and follow up measures was documented for the main anthropometric measures (weight, height, BMI). In addition, a significant increase of IGF-1 values was documented at follow-up. The height SDS at follow up was significantly related with target height, target height-SDS, height, height-SDS, weight, weight SDS; in addition a negatively correlation was documented with GH values obtained during GH stimulation test and IGF-1 values at baseline.

Conclusions: In this study we demonstrated that the main predictive factors of GH therapy are anthropometric measurements and changes in IGF-1 values during treatment. Therefore, both IGF-1 and anthropometric measurements, should be taken into account to provide optimal management of the patient with short stature and to predict therapeutic success.

Volume 95

60th Annual ESPE (ESPE 2022)

Rome, Italy
15 Sep 2022 - 17 Sep 2022

European Society for Paediatric Endocrinology 

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