ESPE2022 Rapid Free Communications Thyroid (6 abstracts)
Background: Preterm newborns (PN) are at risk of developing congenital hypothyroidism (CH) with a high reported incidence (1:300 vs 1:2000 for at term newborns). The study's objective was to determine the TSH percentiles at neonatal screening (NS) in PN and to analyze the incidence of permanent and transient CH in this population.
Materials and Methods: PN born in the Piedmont Region of Italy in the period 2019-2021 were included.
Results: NS was performed by TSH detection on Guthrie cards in 5930 PN. The first TSH analysis was made at 3.3 ±1.48, the second at 15±1.4 and the third at 26.8±15.4 days of life. TSH mean levels and percentiles are represented in Table 1.
|1st detection (n=5930)||2.3±0.02||0.2||0.4||1.17||1.9||3||6.4||8.5|
|2nd detection (n=5130)||1.77±0.02||0.3||0.4||1||1.5||2.2||4.5||5.7|
|3rd detection (540)||1.56±0.02||0.2||0.36||1.1||1.6||2.55||4.7||5.17|
TSH levels considering weight and gestational age (GA) are shown in Table 2 and 3, respectively.
|<1000 g||1000-1499 g||1500-2500 g||>2500 g||p||p|
|1st detection||2.08±0.15||2.01±0.08||2.28±0.03||2.41±0.03||P< 0.005||P< 0.005|
|2nd detection||2.13±0.11||2.32±0.23||1.93±0.04||1.62±0.02||P< 0.005||P< 0.005|
|22-<28 w||28-<32 w||32-<34 w||34-<37 w|
|1st detection||1.71±0.09||1.87±0.06||1.94±0.05||2.42±0.02||P< 0.005|
|2nd detection||1.89±0.11||2.15±0.21||2.2±0.16||1.75±0.02||P< 0.005|
NS results for each TSH detection are depicted in Table 4. CH incidence was 1:156; in those born in 2019-20 the percentage of transient CH was 65%.
|Normal||TSH re-evaluation by screening||Serum TSH evaluation||CH|
Conclusion: The incidence of CH in PN is much higher than in at term infants. In PN, targeted NS strategies are needed which should consider both neonatal weight and GA.
15 Sep 2022 - 17 Sep 2022