Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

Free Communications

Diabetes and insulin 2

hrp0097fc9.1 | Diabetes and insulin 2 | ESPE2023

Reference values for the insulin response to glucose challenge enable the early detection of emerging (pre)diabetes in children and young adults with obesity

Stein Robert , Vogel Mandy , Stanik Juraj , Kratzsch Jürgen , Stumvoll Michael , Blüher Matthias , Kiess Wieland , Körner Antje

Background: The course of type 2 diabetes is more severe among children with obesity than among adults. Therefore, children at high risk for glycemic deterioration should be detected early enough to guide preventive (and interventional) clinical management.Methods: We established age- and puberty-specific reference values for 7 different indexes addressing the insulin response during oral glucose tolerance testing upon 4...

hrp0097fc9.2 | Diabetes and insulin 2 | ESPE2023

Characterization of pediatric patients with type 2 diabetes and trends in their pharmaceutical management 2000-2022 in German-speaking countries: Analysis based on the DPV registry

Becker Marianne , Wiegand Susanna , Schmid Stefanie , Weghuber Daniel , Weihrauch-Blüher Susann , Reinehr Thomas , Kapellen Thomas , Tauschmann Martin , Denzer Christian , Körner Antje , W Holl Reinhard

Introduction: The prevalence of pediatric type 2 diabetes (T2D) increased over the last 2 decades, related to the rise in obesity. Meanwhile, treatment options for T2D have evolved considerably. Therefore, we analyzed changes in treatment approaches for pediatric T2D over two decades.Material and Methods: Patients with T2D from 321 pediatric diabetes centers (Austria 24, Switzerland 2, Luxemburg 1, Germany 290) were reco...

hrp0097fc9.3 | Diabetes and insulin 2 | ESPE2023

A novel case of hypoglycaemia secondary to a pro-insulin processing disorder

Amin Nadia , Wark Gwen , Church David , Burling Keith , Barker Peter , Williams Gemma , O'Rahilly Stephen

Background: Hypoglycaemia in patients with a high concentration of insulin and low concentration of C-peptide can be secondary to administration of exogenous insulin. This often results in safeguarding measures, with significant consequences for the patient and family. We report a novel case of a patient with symptomatic hypoglycaemia. Initial results suggested high insulin and low C-peptide levels, but subsequent testing revealed a pro-insulin processing diso...

hrp0097fc9.4 | Diabetes and insulin 2 | ESPE2023

The high proportion of INS-MODY in Chinese children with MODY

Ding Yu , Zhang Qianwen , Li Niu , Chang Guoying , Li Juan , Chen Yao , Yao Ru-en , Yu Tingting , Wang Xiumin

Background: The incidence rate of maturity onset diabetes of the young (MODY) and the proportion of different types of MODY will be different in different countries and races. GCK, HNF1A, and HNF4A are the three most common types of MODY, but the occurrence of other rare MODY subtypes in Chinese children is unknown. Therefore, studying the case group of MODY in Chinese children can help deepen understanding of MODY, early identification, and precise treatment....

hrp0097fc9.5 | Diabetes and insulin 2 | ESPE2023

A case of NARS1 deficiency resulting in diabetes mellitus with liver cirrhosis and pancreatic atrophy

Higuchi Shinji , Kitayama Kana , Yorifuji Tohru , Mori Jun

Background: Aminoacyl tRNA synthetases (ARSs) are enzymes that bind amino acids to tRNAs, and many of their genetic variants are known to be pathogenic. Asparaginyl Aminoacyl tRNA synthetase (NARS1) deficiency was first reported as a cause of microcephaly in 2020. NARS1 deficiency is characterized by microcephaly, psychomotor retardation, epilepsy, congenital abnormalities of the limbs and skeleton, and a peculiar facial appearance. However, there have been no...

hrp0097fc9.6 | Diabetes and insulin 2 | ESPE2023

Puberty and Gonadal function in Wolfram Syndrome: A retrospective single centre study

Cunningham Olivia , Newell Laura , McCarthy Liam , Williams Denise , Barrett Timothy , Dias Renuka

Background: Wolfram Syndrome (WS) is a rare progressive neurodegenerative disorder characterised by early-onset diabetes and optic atrophy as well as a variable spectrum of other clinical features. It is caused by mutations in the WFS1 gene. There is currently limited published literature on pubertal progression and gonadal function in WS.Aims: To review the gonadal function and pubertal progression of a cohort of adoles...