Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

Free Communications

Pituitary, neuroendocrinology and puberty 1

hrp0097fc6.1 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Methylome analysis in idiopathic central precocious puberty girls

Palumbo Stefania , Giurato Giorgio , Cirillo Grazia , Miraglia del Giudice Emanuele , Palumbo Domenico , Grandone Anna

Background: Although the transition from the pre-pubertal condition to puberty occurs physiologically within a bounded age range, recent data indicate a central role for epigenetics in the regulation of several genes that could mediate an alteration of pubertal onset. Moreover, changes occurring during this developmental stage have often been associated with susceptibility to a wide range of diseases in later life. To identify changes in DNA methylation profil...

hrp0097fc6.2 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

The role of body composition and appetite-regulating hormones in idiopathic central precocious puberty and their changes during GnRH analogue therapy.

Tarçın Gürkan , Bayramoğlu Elvan , Güneş Kaya Didem , Karakaş Hasan , Turan Hande , Evliyaoğlu Olcay

Aim: This study aimed to compare the levels of appetite-regulating hormones (ghrelin, leptin, peptide-YY (PYY), neuropeptide-Y (NPY)) in girls with idiopathic central precocious puberty (ICPP) before treatment with prepubertal girls, and to evaluate changes in these hormone levels and body composition during leuprolide acetate (LA) treatment.Methods: This prospective, cross-sectional study included girls with ICPP, isola...

hrp0097fc6.3 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Is the 24-hour urinary gonadotropin assay an effective diagnostic tool in central precocious puberty? A retrospective study of threshold setting and validation in two cohorts.

Janot Clément , Perrin Pauline , Bretones Patricia , Malburet-Testori Sarah , Perge Kevin , Raverot Véronique , Robert Zoé , Roucher-Boulez Florence , Villanueva Carine , Nicolino Marc , Plotton Ingrid

Background and Aims: Central Precocious Puberty (CPP) caused by the early activation of the hypothalamic-pituitary-gonadal axis is a rare affection that occurs in 0.2% in girls. Clinical signs are suggestive and LHRH-test could be sometimes difficult to use and not always contributive. Gonadotropin assay in twenty-four hours-urinary collection could be an interesting option. The present work intended to evaluate the diagnostic interest of 24-hour urinary gonad...

hrp0097fc6.4 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Sleeptime-excreted total urinary luteinizing hormone concentrations reveal that the onset of central puberty occurs at around the same time in boys and girls: a longitudinal study

Demir And , Hero Matti , Juul Anders , M. Main Katharina

Objectives: We designed a longitudinal study to investigate the association between central pubertal activation with age at the appearance of clinical signs of puberty. We, therefore, assessed nocturnal gonadotropin secretion which can be detected in the form of total luteinizing hormone (LH) immunoreactivity in the daytime- and sleeptime-excreted urine.Methods: Thirty healthy volunteers (17 boys and 13 girls, aged 3.4&n...

hrp0097fc6.5 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Clinical characteristics of 213 children with early pubertal development complicated with pineal cyst

Yuan Shuxian , Lin Yifan , Zhao Yixuan , Chen Yongxing , Wei Haiyan

Background: Previous studies have speculated that melatonin secreted by the pineal gland plays a role in the regulation of puberty, and pineal cyst may affect its secretory function, thus causing early pubertal development. However, there are few studies on early pubertal development with pineal cyst and its clinical features are not clear. This study aims to explore its clinical features and the relationship with cyst size to further improve the understanding...

hrp0097fc6.6 | Pituitary, neuroendocrinology and puberty 1 | ESPE2023

Serum Kisspeptin and DLK1 levels as a tool for diagnosis and monitoring of central precocious puberty treatment in Thai girls

Onsoi Witchuwan , Numsriskulrat Nattakarn , Srilanchakon Khomsak , Aroonparkmongkol Suphab , Supornsilchai Vichit

Background: Kisspeptin and Delta-like 1 homolog (DLK1) are neuropeptides that regulate pubertal timing by activating and inhibiting the hypothalamic-pituitary-gonadal axis; consequently, measuring these biomarkers could potentially distinguish central precocious puberty (CPP) from premature thelarche (PT) girls and monitor CPP treatment.Objectives: To compare baseline serum kisspeptin and DLK1 levels in girls with CPP at...