ESPE Abstracts (2023) 97 P1-443

ESPE2023 Poster Category 1 Diabetes and Insulin (55 abstracts)

To study the prognostic significance of the molecule intercell adhesion type 1 (ICAM1 – intercellularadhesion molecule type 1, CD54) and adhesion moleculesvascular endothelium type 1 (VCAM1 - vascularcell adhesion molecule type 1, CD106) in children with type 1 diabetes mellitus after COVID 19 infection

Malika Aripova , Feruza Khaydarova , Nasiba Alimova , Anna Alieva & Aqida Sadikova

Centr of Endocrinology, Tashkent, Uzbekistan

The study was aimed at assessing the relationship between increased titers of intercellular adhesion molecules ICAM VCAM in order to assess the risk of developing vascular lesions in children with type 1 diabetes

Introduction: COVID-19 induces a systemic inflammatory response, including dysregulation and misexpression of many inflammatory cytokines [1]. Inflammatory cell recruitment and activation depends on the expression of many classes of inflammatory mediators such as cytokines (interleukin [IL]-1, IL-6, and IL-18), chemokines (fractalkin [FKN]), and adhesion molecules. (intercellular adhesion molecule 1 [ICAM-1)] and vascular cell adhesion molecule-1 [VCAM-1]) [2]. The aim of the study: To study the level of ICAM and VCAM in the blood serum of children with type 1 Diabetes mellitus after a Covid infection.

Research Methods: The titers of ICAM and VCAM in blood serum were determined by enzyme immunoassay in 60 children with type 1 Diabetes mellitus who had Covid infection. Reultats: 60 children with type 1 diabetes mellitus who had COVID infection were examined. In 75.9% of children, covid was asymptomatic. It was possible to identify such children by interviewing and collecting anamnesis. They had an outbreak in their family. The titers of antibodies to COVID in parents and patients are increased. The titers of antibodies to SARS CoV were 559.7 ±117.9 (norm >1.0). In the blood serum, the ICAM titer was 45.9 ± 3.9 at the norm (0.84 – 8.45 ng/ml), the VCAM titer was 665.1 ± 120.1 (5.08 – 47.72 ng/ml), which indicates a significant increase in these indicators.

Conclusion: Many studies have been conducted to assess the informativeness of the ICAM 1 VCAM-1 definition in various infectious pathologies. But there is little data for an increase in ICAM VCAM in children with diabetes mellitus after a covid infection. Which once again suggests the idea of further studying this phenomenon and predicting future complications.

Volume 97

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

European Society for Paediatric Endocrinology 

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