Diabetes and Insulin

hrp0097p1-31 | Diabetes and Insulin | ESPE2023

Metabolic trajectories during treatment of diabetic ketoacidosis described by breath analysis

Awchi Mo , Dev Singh Kapil , Bachmann-Brenner Sara , Burckhardt Marie-Anne , Hess Melanie , Zumsteg Urs , Zeng Jiafa , N. Datta Alexandre , Frey Urs , Szinnai Gabor , Sinues Pablo

Objective: This feasibility study aimed to investigate the anabolic effect of insulin on metabolites captured in exhaled breath during acute diabetic ketoacidosis (DKA) for a better pathophysiological understanding.Research Design and Methods: Children and adolescents with type 1 diabetes (T1D) with DKA (n=5) and without DKA (n=7) and children with epilepsy without ketogenic diet (n=18) were re...

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hrp0097p1-32 | Diabetes and Insulin | ESPE2023

Continuous Glucose Monitoring: A possible aid to detect hypoglycemia event during insulin challenge tests

Yeun Sim Soo , Jin Park Su , Bae Ahn Moon , Suh Byung-Kyu

Combined pituitary function test is a dynamic function test used to evaluate the anterior pituitary gland in patients suspected with hypopituitarism. The test comprises insulin challenge test where intravenous insulin injection in order to induce symptomatic hypoglycemia (serum blood glucose <40mg/dL). Insufficient increase in growth hormone and cortisol after the stimulation confirms the diagnosis of growth hormone deficiency and/or adrenal function insufficiency. However,...

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hrp0097p1-33 | Diabetes and Insulin | ESPE2023

Health-Related Quality of Life in Children and Adolescents with Type1 Diabetes Mellitus

Alkhouli Laila , Al Remeithi Sareea , Al Jeneibi Sara

Background: HRQoL has been acknowledged as an essential health outcome measure. Studies have shown that enhancing the HRQoL and well-being of children with diabetes is as important as metabolic control in preventing secondary morbidity. Objectives: to evaluate HRQoL of children and adolescents with T1D managed at our institute and investigate factors (patient and disease-related) associated with HQoL scores.Methods: a cr...

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hrp0097p1-34 | Diabetes and Insulin | ESPE2023

Evaluation of Mitochondrial Bioenergetic Function in Mitochondrial and Type 1 Diabetes

Gurpinar Tosun Busra , Francisco Annelise , D. C. Navarro Claudia , Seven Menevse Tuba , Polat Hamza , Ozturk Hismi Burcu , Kahveci Ahmet , Turan Serap , Haliloglu Belma , Mine Yilmaz Ayse , Karademir Yilmaz Betul , Bereket Abdullah , F. Castilho Roger , Guran Tulay

Background and hypothesis: Mitochondrial disorders are multisystemic conditions associated with sensorineural hearing loss, encephalomyopathy, lactic acidosis, and non-autoimmune diabetes. The majority of molecular etiologies involve mutations in the genes encoding the oxidative phosphorylation system's components. Superoxide generation is significantly increased and causes oxidative damage in the affected tissues in these disorders. The establishment of ...

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hrp0097p1-35 | Diabetes and Insulin | ESPE2023

Effects of insulin therapy on respiratory functions, pulmonary exacerbation and nutritional status in cystic fibrosis-related diabetes

Vuralli Dogus , Alboga Didem , Senkalfa Burcu , Gozmen Onur , Yalcin Ebru , Dogru Ersoz Deniz , Ozcelik Ugur , Kiper Nural , Gonc Nazli , Ozon Alev

Background and Aim: Cystic fibrosis-related diabetes (CFRD) is a common extrapulmonary comorbidity in patients with cystic fibrosis (CF). Since CFRD is clinically silent in the early period, it is recommended to evaluate glucose metabolism with an oral glucose tolerance test (OGTT) annually in CF patients aged 10 years and older. Insulin therapy is thought to improve lung function and nutritional status in patients with CFRD. In this study, we aimed to evaluat...

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hrp0097p1-36 | Diabetes and Insulin | ESPE2023

Incidence of Newly Diagnosed Childhood Diabetes and Severity at Onset Between Pre-Pandemic and Pandemic COVID-19 Eras in Northern Thailand

Sinthuprasith Pattharaporn , Wejaphikul Karn , Puttawong Dolrutai , Tang-Ngam Hataitip , Sanrattana Naphatsorn , Unachak Kevalee , Dejkhamron Prapai

Background: The incidence rate (IR) of childhood diabetes is increasing globally. These upward trends were also found in Thailand. However, newly diagnosed childhood diabetes incidences are not updated, especially in Northern Thailand. There are possibilities that COVID-19 pandemic affects the development of acute diabetes after infection and the severity of the first clinical presentation of childhood diabetes. However, data are also conflicting regarding the...

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hrp0097p1-37 | Diabetes and Insulin | ESPE2023

Dietary Intake in Children and youth with Type 1 Diabetes from Different Ethnic Backgrounds and its Relation to Different Metabolic Parameters

M. Heifetz Eliyahu , Avnon- Ziv Carmit , Auerbauch Adi , Dagan Tal , Hershkop Karen , Levy-Khademi Floris

Background: Medical nutrition therapy is one of the cornerstones of the treatment of type 1 diabetes. Nutrition is affected by many factors including ethnicity, socioeconomic background, and culture.Objectives: To evaluate the nutritional status in a cohort of children with type 1 diabetes from different ethnic backgrounds and to seek differences among the groups. In addition determine the effect of nutrition on metaboli...

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hrp0097p1-38 | Diabetes and Insulin | ESPE2023

Efficacy of faster aspart in insulin pumps in children and adolescents with Type 1 Diabetes Mellitus: A single-center study with real-world data

Sotiriou Georgia , Christelia Katerina , Stamati Athina , Dimitriadou Meropi , Christoforidis Athanasios

Aim: To assess the efficacy of faster aspart (FIAsp) in paediatric population with type 1 diabetes mellitus (T1DM) and insulin pumps in real-world settings.Methods: We conducted a prospective analysis of 16 children and adolescents with T1DM on insulin pump that switched from Aspart to FIAsp from September 2019 to June 2020. We performed within groups and between groups analyses in three time points: 3 months before FIAs...

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hrp0097p1-39 | Diabetes and Insulin | ESPE2023

Prevalence of Insulin-induced Lipohypertrophy (LD) in children and Adolescents with Type 1 Diabetes Mellitus in relation to important risk factors: Review of literature in the past 15 years in 11 countries

Soliman Ashraf , De Sanctis Vincenzo , Alaaraj Nada , Ahmed Shayma , Hamed Noor , Alyafei Fawzia

Abstract: Epidemiological and clinical data on LD in children and adolescents with T1DM are growing since 2010 because of the introduction of new insulin analogs and the use of insulin pumps (CSII). Many risk factors predispose to the occurrence of LD.Objectives and Methods: We performed an electronic search in PubMed, Google scholar and Web of Sciences to evaluate the global prevalence and possible risk factors of LD in...

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hrp0097p1-40 | Diabetes and Insulin | ESPE2023

Neopterin and tryptophan pathways in children with type 1 diabetes: isoxanthopteridine as a marker of endothelial dysfunction

Evliyaoğlu Olcay , Özer Yavuz , Kıykım Ertuğrul , Serif Cansever Mehmet , Turan Hande , Bayramoglu Elvan , Ceyhun Emre , İşat Esra , Zübarioğlu Tanyel , Cigdem Aktuglu Zeybek Ayse

Introduct&idot;on: Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by damage to β cells in the pancreas. Neopterins and indolamine 2,3-dioxygenase (IDO) activity, which is shown by the ratio of kynurenine to tryptophan, can be used as an indicator in the regulation of cellular immunity. Oxidative stress produced by xanthine oxidoreductase has been shown to be associated with vascular endothelial dysfunction. It uses the conversion of p...

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hrp0097p1-41 | Diabetes and Insulin | ESPE2023

ADIPOQ gene (adiponectin) causing neonatal diabetes mellitus in a Palestinian newborn

Abu-Libdeh Abdulsalam , Zanged David

Background: Monogenic diabetes is a type of diabetes resulting from mutations of a single gene that may be spontaneous de novo or autosomal dominant or recessive. Reported incidence is 1-4% and confirmed by molecular genetic testing. Transient neonatal diabetes is usually diagnosed within the first week of life and resolves around 12 weeks. Permanent neonatal diabetes should be considered in all children presenting with diabetes in first month of age, and do n...

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hrp0097p1-42 | Diabetes and Insulin | ESPE2023

Type 1 diabetes in the covid pandemic: what changed?

Diogo Rui , Rua Inês , Cardoso Rita , Dinis Isabel , Mirante Alice , Serra-Caetano Joana

Introduction: The COVID-19 pandemic adversely impacted general access to healthcare. An association between SARS-CoV-2 infection and new-onset type 1 Diabetes (T1D), a more severe disease at diagnosis and a worsening diabetes control have been described.Aim: To evaluate COVID-19 pandemic’s impact in incidence and presentation of T1D on paediatric patients.Material and Methods:</strong...

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hrp0097p1-43 | Diabetes and Insulin | ESPE2023

Our experience in neonatal diabetes mellitus: clinical and molecular characterisation

Salamanca Fresno Luis , Gomes Porras Mariana , Pozo Román Jesús , Del Pozo Ángela , Rodríguez Jiménez Carmen , González Casado Isabel , Campos Barros Ángel

Introduction: Neonatal Diabetes Mellitus (NDM) is characterised by severe hyperglycaemia, usually diagnosed in the first 6 months of life. Genetic diagnosis helps distinguishing between its different causes and between transient (TNDM) and permanent (PNDM) forms, with repercussions on the therapeutic approach and follow-up.Aim: Clinical and molecular characterisation of a series of NMD cases under endocrinological follow...

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hrp0097p1-44 | Diabetes and Insulin | ESPE2023

New-onset DKA in a child complicated by hypertriglyceridemia and acute pancreatitis.

Mustafa Manal

Introduction: DKA is one of the most common pediatric emergencies. Hypertriglyceridemia and acute pancreatitis are infrequent complications of DKA. We present a 9-year-old female with new-onset DKA who presented with acute pancreatitis and hypertriglyceridemia and resolved on follow-up.Case presentation: A 9-year-old female, previously healthy, non-obese, presented to the hospital with breathing difficulty, abdominal pai...

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hrp0097p1-45 | Diabetes and Insulin | ESPE2023

Common challenges of one uncommon syndrome - single center experience with Congenital Generalized Lipodystrophy

Slavcheva - Prodanova Olga , Archinkova Margarita , Yaneva Natasha , Modeva Iskra , Dimova Ivanka , Savova Radka

Aim: To present some therapeutic difficulties in patients with congenital generalized lipodystrophy (CGL) - a rare autosome recessive disorder characterized by complete absence of adipose tissue. For many years therapy was aimed only at metabolic consequences. In the past few years new pathophysiologic treatment has become available.Methods and materials: We present four girls – currently 25, 22, 16 and 15 years ol...

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hrp0097p1-46 | Diabetes and Insulin | ESPE2023

Associated autoinmmunity in children and adolescents with type 1 diabetes mellitus

Reinoso Andrea , García Rusca Elizabeth , Rosa Moreno Maria , Claudia Pérez María , Fasano Victoria , Balbi Viviana , Morín Analía , Pietropaolo Guadalupe

Introduction: Autoimmune thyroid diseases (ATD) are the most common autoimmune disorders associated with type 1 diabetes (T1D). Most patients present hypothyroidism. Although hyperthyroidism is less frequent, severe forms of thyrotoxicosis coexisting with diabetic ketoacidosis (DK) have been described in children with either preexisting diabetes, thyroid disease, or both. Celiac disease (CD) incidence is higher and ranges from 0.6-16.4%....

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hrp0097p1-47 | Diabetes and Insulin | ESPE2023

The retrospective/blind glucose monitoring (bCGM) system is valuable tool for hyperglycemic and hypoglycemic states

Demirbas Ozgecan , Denkboy Ongen Yasemin , Eren Erdal

Introduction: The retrospective/blind glucose monitoring (bCGM) system or glucose sensors commonly used for type 1 diabetes management. The approach to hyperglycemic and hypoglycemic states is an urgent and essential issue in terms of diagnosis/treatment. Many tests are performed for the diagnostic process. We aimed to evaluate the effectiveness of bCGM (iPro™2 system) in the follow-up and treatment of patients to our clinics with hypoglycemia/hyperglyce...

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hrp0097p1-48 | Diabetes and Insulin | ESPE2023

Changing Diabetes in Children Indonesia: Public-private partnership to improve healthcare access for children and adolescents with type 1 diabetes mellitus

B. Pulungan Aman , Amalia Gassani , Septira Salsabila , Vathania Nabila , Faizi Muhammad , Fadiana Ghaisani

Background: In 2022, 1.52 million children and adolescents worldwide were diagnosed with type 1 diabetes mellitus (T1DM). During COVID-19, diabetic ketoacidosis (DKA) episodes in newly-onset and established cases increased in 44.2% and 30.1% of paediatric diabetes centres, respectively. In 2017-2019, 1,249 children were diagnosed with T1DM in Indonesia, and 70% were diagnosed with DKA at diagnosis in 2017. Changing Diabetes in Children (CDiC) is a public-priva...

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hrp0097p1-49 | Diabetes and Insulin | ESPE2023

Quantiferon test versus Tuberculin test to screen for Latent Tuberculosis in Type 1 diabetic children: a single center experience.

Abdel Hamid Ehab , Khater Doaa , Abdelmeguid Yasmine , Mansour Saad , Rabie Rehab , Ibrahim Naglaa

Background: Type 1 DM (T1DM) is a chronic condition characterized by persistent hyperglycemia; which can impair immunity and increase susceptibility to infections. Latent TB infection (LTBI) is a subclinical infection caused by Myobactaeria tuberculosis antigens without clinical, bacteriological or radiological evidence of manifest TB disease. Tuberculin test (TST) is an inexpensive test used to identify LTBI status, but has limitations. False positive TST can...

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hrp0097p1-228 | Diabetes and Insulin | ESPE2023

Secondary PREvention of Diabetes Type 1 with oral CALcitriol and analogs, the PRECAL study

T. Papadimitriou Dimitrios , Dermitzaki Eleni , Christopoulos Panagiotis , Papagianni Maria , Kleanthous Kleanthis , Papadimitriou Anastasios , Mastorakos George

Type 1 diabetes (T1D) hits about 1:300 with rising incidence affecting increasingly younger children. Population screening at ages 2-6yrs with T1D associated autoantibodies (T1Ab) has been recently proven sensitive. While potential treatments to prevent or delay T1D are currently in development, a population based cost-effective preventive strategy is still lacking. Hence, 2000IU cholecalciferol daily in a large birth cohort study published in 2001 reduced by 80% the risk of T...

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hrp0097p1-229 | Diabetes and Insulin | ESPE2023

Trajectories of glycemic control in transition-aged patients with type 1 diabetes

Jee Kim Min , Jeong Lee Yun , Ho Shin Choong , Ah Lee Young

Objectives: We investigated the trajectories in hemoglobin A1C (A1C) levels among transition-aged patients (age from 15 to 22 years) with type 1 diabetes (T1D).Methods: Among the patients diagnosed with type 1 diabetes in pediatric age between 2001 and 2013 in Seoul National University Children’s Hospital, 119 patients (54 males and 65 females) with a diagnostic age for under 14 and measurement of A1C at least once...

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hrp0097p1-230 | Diabetes and Insulin | ESPE2023

Motivational interviewing from the pediatricians' perspective: assessments after a 2-day training for physicians caring for adolescents with chronic medical conditions (CMCs)

Kammering Hannah , Antony Cruz Jennifer , Lena Platzbecker Anna , Reinauer Christina , Viermann Rabea , Förtsch Katharina , Krassuki Lisa , Meissner Thomas , Domhardt Matthias , Baumeister Harald , Staab Doris , Minden Kirsten , Sandra Mueller-Stierlin Annabel , W. Holl Reinhard , Warschburger Petra

Background: Counselling adolescents with chronic diseases can be challenging when it comes to appropriate interview techniques and the doctor's attitude towards the patient. Successful communication can be a key element of treatment. Motivational interviewing (MI) is widely applicable in the management of behavioural problems and illnesses, as it increases patients' motivation for lifestyle changes. This plays a particularly important role in the tre...

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hrp0097p1-231 | Diabetes and Insulin | ESPE2023

Children with Type 1 Diabetes and Obesity show biochemical changes associated with insulin resistance

Hayes Eadaoin , Cody Declan , E Hogan Andrew

Children with Type 1 diabetes are experiencing higher levels of overweight and obesity as a consequence of intensive insulin therapy as well as background socioeconomic and environmental factors that are contributing to excess adiposity in the general population. The consequences of obesity in people with type 1 diabetes are of particular concern, as obesity in adults increases the risk of both diabetes-related and obesity-related complications, including cardiovascular diseas...

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hrp0097p1-232 | Diabetes and Insulin | ESPE2023

A Case with Alstrom Syndrome with a Novel Pathogenic Variant In ALMS1 gene as a Rare Cause of Diabetes Mellitus

Dağdeviren Çakır Aydilek , Gizem Bolaç Özyılmaz Leyla , Uçar Ahmet

Introduction: Alstrom syndrome (ALMS) is an autosomal recessive disorder characterized by multiple organ involvement, including progressive cone-rod dystrophy, sensorineural hearing loss, childhood obesity, and type 2 diabetes mellitus. Pathogenic variants in the ALMS1 gene are the known cause for the occurrence of this devastating condition. Here, we reported a case of Alstrom syndrome with a novel homozygous variant in the ALMS gene, who presented to our cli...

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hrp0097p1-233 | Diabetes and Insulin | ESPE2023

Diabetes Behind the Mask

Gürpınar Gözde , Koçyiğit Esra , Hürmüzlü Közler Selen , Kilci Fatih , Gür Aykut Gizem , As Yeşilorman Sıdıka , Küçükkeskin , Huw Jones Jeremy , Mine Çizmecioğlu Jones Sema Filiz

Keywords: diabetes, MODY, atypicalIntroduction: Type 1 Diabetes (T1D) is the most common cause of diabetes in childhood, but Type 2 Diabetes (T2D) and monogenic diabetes has attracted increasing attention recently. Cases with atypical diabetes may be challenging for diagnosis, treatment and follow-up management. The purpose of this study was to present the characteristics of atypical diabetes cases from a tertiary referr...

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hrp0097p1-234 | Diabetes and Insulin | ESPE2023

Health services for children with diabetes mellitus in Dnipro, Ukraine

Yenhovatova Viktoria , Globa Evgenia , Zelinska Natalia

As of 2022, the Ukraine Pediatric Diabetes Register (UPDR) contained children aged <18 years with DM1- 11014 (1 in 677), with DM2 – 51 (1 in 146274), with neonatal diabetes (ND) – 69 (1 in 108115), and 59 cases (1 in 126440) with MODY. Most studies focus on such parameters as HbA1c, acute complications and quality of life, whereas investigations of the frequency of chronic DM1 complications and glycemic control for internally displaced persons (IDP) have not bee...

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hrp0097p1-235 | Diabetes and Insulin | ESPE2023

Recurrence Risk Of T1DM In First Or Second Degree Relatives: First Indian Report

Godbole Tushar , Gogate Yashpal

Objective: Lifetime risk of having Type 1 Diabetes Mellitus [T1DM] increases when having a blood relative with T1DM. A Finish study reports 12.2% and 11.9% of T1DMs having a first degree relative [FDR] and second degree relative [SDR] with T1DM[1]. Data from India regarding proportion of children with T1DM FDR/SDR is non-existent. Objective is to find out the same.Methods: We examined the electronic database of 902 T1DM ...

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hrp0097p1-236 | Diabetes and Insulin | ESPE2023

The impact of covid-19 pandemic on the incidence type 1 diabetes in children

Kurmacheva Nataliia , Svinarev Michail , Chernenkov Yuriy , Gumeniuk Olga , Aranovich Vera

Viral infections may increase the risk of developing type 1 diabetes (T1D), and recent reports suggest that Coronavirus Disease 2019 (COVID-19) might have increased the incidence of pediatric T1D (M. Rahmati et al., 2022). In general, the course of viral infection in children is mild, the question of the long-term effects of COVID-19 on a child and adolescent, in particular, on pancreatic beta cells, remains unclear.Purpose: To ...

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hrp0097p1-237 | Diabetes and Insulin | ESPE2023

Effects of the COVID-19 pandemic on anthropometric data, glycemic control, and lipid levels in children and young people with type 1 diabetes: two years of follow-up

Iughetti Lorenzo , Candia Francesco , Stefanelli Francesca , Trevisani Viola , F. Madeo Simona , Bruzzi Patrizia , Predieri Barbara

Introduction: The beginning of the COVID-19 pandemic encouraged a sedentary lifestyle and “covibesity” was reported. Concerns for consequences on anthropometric data, glycemic control, and lipid profile in subjects with type 1 diabetes (T1D) were raised.Objectives: Longitudinal and observational study aimed to investigate the 2-years effects of the COVID-19 pandemic on BMI, glycemic control, and lipid profile...

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hrp0097p1-238 | Diabetes and Insulin | ESPE2023

MiniMed 780G Advanced Hybrid Closed Loop System Outcomes According to Pubertal Status - Awesome Study Group Real-Life Experience

Rachmiel Marianna , Lebenthal Yael , Kineret Mazor-Aronovitch Kineret , Brener Avivit , Levek Noah , Polishuk-Yakobi Talia , Tal Ben Tal , Abiri Shirli , Landau Zohar , Pinhas-Hamiel Orit

Background and aims: Achieving good glycemic control is a major challenge for adolescents with type 1 diabetes (TID). The introduction of the MiniMed 780G system, an advanced hybrid closed-loop (AHCL), that enables an automatic correction of insulin, gave hope for improved glycemic outcomes in adolescents. We assessed specific characteristics associated with glycemic measures in youth with T1D switching to Minimed 780G.Methods:</...

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hrp0097p1-239 | Diabetes and Insulin | ESPE2023

Epidemiology of Type 1 Diabetes among children under 15 years of age in Navarre (Northern Spain) between 2012-2022

J. Chueca Maria , Berrade Sara , Andres Carlos , Elcano Leire , Bello Paula , Burillo Elisabet

The incidence of TIDM varies greatly between different countries and regions. In Navarre, located in the north of Spain, at the western end of the Pyrenees, there has been a clear increase in the incidence of TIDM, from 13,5 cases per 100000 in the decade 1990-2000 to 20,1 cases per 100000 between 2006-2011. We wonder if this upward trend has continued in recent years. Our hospital is a reference center for Pediatric Endocrinology in Navarre.Obje...

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hrp0097p1-240 | Diabetes and Insulin | ESPE2023

Age differences in the distribution of diabetes-specific antibodies in children and adolescents with type 1 diabetes mellitus

Schweizer Roland , Mayer David , Bung Julia , Liebrich Franziska , Neu Andreas , Ziegler Julian

Background: The assignment to type 1 diabetes mellitus (T1DM) can be confirmed by the determination of diabetes-specific autoantibodies. Five different antibodies can be determined. The determination of several antibodies is more expensive than the determination of a single antibody. In times of scarce resources, the sequential determination of antibodies could save costs. The aim of this study was to determine the frequency of antibodies and their age and gen...

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hrp0097p1-241 | Diabetes and Insulin | ESPE2023

Association between osteocalcin and secretory function of islet beta cells in diabetic pediatric population: a pivotal study

Lombardo Fortunato , Passanisi Stefano , Lombardo Cristina , Salzano Giuseppina , Bombaci Bruno , Lugarà Cecilia , D' Amico Federica , Grasso Loredana , Aguennouz M'Hammed , Catalano Antonino , Valenzise Mariella

Background: Osteocalcin plays a role in glucose metabolism in mice, but its relevance in human energetic metabolism is controversial. Few data are available on osteocalcin in pediatric patients with T1DM. The aim of our monocenter observational study was to evaluate the role of the main remodelling bone biomarkers in the regulation of glucose metabolism at the time of type 1 diabetes diagnosis and to evaluate their potential relationship with insulin sensitivi...

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hrp0097p1-242 | Diabetes and Insulin | ESPE2023

Prevalence of Insulin-induced Lipohypertrophy (LD) in Type 1 Diabetes Mellitus (T1DM): CSII versus MDIT and Children versus adults.: Review of literature in the past 15 years in 10 countries.

Soliman Ashraf , De Sanctis Vincenzo , Ahmed Shayma , Hamed Noor , Alyafei Fawzia , Alaaraj Nada

Lipohypertrophy (LD) represents the most common cutaneous complication of insulin therapy worldwide. Epidemiological and clinical data on LD in children and adolescents with T1DM are growing since 2010 because of the introduction of new insulin analogs and the use of insulin pumps (CSII).Objectives and Methods: We performed an electronic search in PubMed, Google scholar and Web of Sciences to evaluate the global prevalence and possible r...

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hrp0097p1-243 | Diabetes and Insulin | ESPE2023

A comparison of Quality of Life in Children with Diabetes Type 1 in Cyprus treated with Multiple daily injections of insulin to children utilizing CGM as adjutant to MDI and to children treated with Continuous Subcutaneous Insulin Infusion.

Sotiriou Elena , Skordis Nicos

Background: Insulin remains the mainstay treatment for diabetes type 1(T1D), more recently several technological advances have been introduced to assist with the treatment. Continuous Subcutaneous insulin infusion (CSII) devices and continues glycose monitors (CGM) have gained a lot of popularity and are thought to help patients achieve better glycaemic control. HbA1c levels can be used to assess glycaemic control. There are conflicting reports on whether thos...

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hrp0097p1-244 | Diabetes and Insulin | ESPE2023

Knowledge of healthcare practitioners before and after paediatric T1DM diagnosis and management training

B. Pulungan Aman , Faizi Muhammad , Amalia Gassani , Septira Salsabila , Vathania Nabila , Fadiana Ghaisani , Citra Ismail Ismi , Sugih Arto Karina , Mayasari Lubis Siska , Deliana Melda , Dewi Saraswati , Nuri Ahmad

Background: An underestimated figure of 1,249 children with type 1 diabetes mellitus (T1DM) was diagnosed in Indonesia from 2017 to 2019. In 2021, there were around 0.05 paediatricians per 1,000 children in Indonesia. Only 1.2% (n=54) were pediatric endocrinologists practising in 17 out of 38 provinces populating urban areas in Indonesia. Therefore, Changing Diabetes in Children (CDiC) Indonesia, a public-private partnership, has delivered training fo...

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hrp0097p1-245 | Diabetes and Insulin | ESPE2023

Combination of mutations in the HNF1A and ABCC8 genes: clinical polymorphism in members of the same family.

Eremina Irina , Raykina Elizaveta , Titovich Elena , Peterkova Valentina , Laptev Dmitry

Mutations in HNF1A gene underlie the development of maturity onset diabetes of the young type 3 (MODY3). Mutations in ABCC8 gene are the cause of neonatal DM and the rare MODY12, which is clinically similar to MODY3. In these forms of MODY, there is a high sensitivity to sulfonylurea. Patient A, 17 y.o. He was born to woman with gestational DM. At the age of 12.5, fasting hyperglycemia of 13 mmol/l was detected. Insulin therapy was not prescribed due to the parent’s refu...

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hrp0097p1-427 | Diabetes and Insulin | ESPE2023

Quality Improvement Initiative to Improve Influenza Vaccination Uptake Rates in Paediatric Patients with Diabetes Mellitus

Shan Carey Lim Yun , Yin Loke Kah , Seng Lee Yung , Andrew Sng Anjian , Su Annette , Yang Xiuji , Li Cindy Ho Wei , Yvonne Lim Yijuan , Hui Nicholas Ng Beng

Introduction: The annual incidence of severe influenza infections reaches 5 million cases globally. Patients with diabetes mellitus (DM) are known to suffer more severe influenza infections, with increased mortality. Despite vaccination being recommended as standard of care, vaccination uptake rates have remained low for our DM patients. We undertook a quality improvement (QI) initiative to improve influenza vaccination uptake rates in our paediatric DM clinic...

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hrp0097p1-428 | Diabetes and Insulin | ESPE2023

Abstract Withdrawn...

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hrp0097p1-429 | Diabetes and Insulin | ESPE2023

Increased Incidence of New-Onset Type 1 Diabetes and Diabetic Ketoacidosis in Children and Adolescents During Coronavirus Pandemic

Milioni Luciano Thais , Govêa Machado Gabriela , Peduti Hallah Oharomari Mariana , Antonini Sonir , Del Roio Liberatore Jr Raphael , Tereza Alves Sarti Mariana

Introduction: Since the beginning of the coronavirus pandemic, an increase in cases of new-onset type 1 diabetes (T1D) in children and adolescents has been observed in many countries, including Brazil.Objectives and Methods: In this descriptive study, we aimed to investigate the frequency of new-onset T1DM and the frequency and severity of diabetic ketoacidosis (DKA) in a referral Brazilian University Hospital, 38 months...

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hrp0097p1-430 | Diabetes and Insulin | ESPE2023

What do they eat? Calculation of carbohydrate, fat and protein intake in children with type 1 diabetes (T1D) by use of an image based analysis by smartphone.

Bachmann Sara , Steiner Gioia , Claude Fabien , Hess Melanie , Szinnai Gabor , Burckhardt Marie-Anne

Background: Carbohydrate counting is essential in diabetes management to match insulin doses to carbohydrate intake. Though recommendations concerning macronutritient composition exist (ISPAD Clinical Practice Consensus Guidelines 2022: Nutritional management in children and adolescents with diabetes), fat and protein intake is usually not calculated. Therefore, little is known if these recommendations are followed. Lower carbohydrate intake is reported to be ...

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hrp0097p1-431 | Diabetes and Insulin | ESPE2023

Telemedicine usefulness in the follow-up of young people with diabetes 1 diabetes 2-years after the spread of COVID-19

Predieri Barbara , Candia Francesco , Stefanelli Francesca , Vandelli Sara , Lucaccioni Laura , Bruzzi Patrizia , Iughetti Lorenzo

Introduction: Telemedicine was adopted during the lockdown due to the COVID-19 pandemic in the follow-up of patients with type 1 diabetes (T1D). Because of its potential to reinforce self-management support outside health care settings it was used still after the lockdown.Objectives: Longitudinal and observational study aimed to investigate effectiveness of telemedicine in the follow-up of young people with T1D over the ...

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hrp0097p1-432 | Diabetes and Insulin | ESPE2023

Prevalence of sleep disorders in children and adolescents with type 1 diabetes and its relation to glycemic control: A single center study

Fawzy Hesham , Elziny Magdy , Aboelenin Hadil , Laymoun Wafaa

Background: Poor sleep quality has been linked to insulin resistance and impaired glucose metabolism, but little is known about sleep and type 1 diabetes (T1D). People with T1D experience higher rates of sleep disturbances than people without diabetes, and these disturbances have negative implications on glycemic control, as well as psychosocial and cognitive outcomes.Objective: To study the prevalence of sleep disorders...

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hrp0097p1-433 | Diabetes and Insulin | ESPE2023

Effects of triple cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy on glucose metabolism in cystic fibrosis patients

Yesquen Pamela , Campos Ariadna , Mogas Eduard , Yeste Diego , Gartnet Silvia , Clemente María

Introduction: Triple CFTR modulator therapy has been shown to improve lung function and quality of life in patients with at least one F508del mutation in the CFTR gen. However, effects on glucose metabolism are not yet well defined. This paper aims to describe the effects of this treatment on glucose metabolism in CF patients.Methodology: Ambispective study.Inclusion criteria: pati...

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hrp0097p1-434 | Diabetes and Insulin | ESPE2023

Monogenic Diabetes gene variants in 323 Greek MODY patients: Targeted NGS increases diagnostic accuracy and allows identification of rare MODY subtypes.

Mertzanian Anny , Sertedaki Amalia , Fylaktou Irene , Binou Maria , Dolianiti Maria , Nikolaides Nikolas , Anargyros Vasilakis Ioannis , Kanana-Gantenbein Christina

Introduction: Maturity Onset Diabetes of the Young (MODY) is clinically and genetically heterogeneous type of Monogenic Diabetes (MD) and to date 14 genes have been associated with different MODY subtypes. It is a rare disease characterized by early onset hyperglycemia, autosomal dominant inheritance, and defect in β cell insulin secretion, often misclassified as T1DM or T2DM.Materials and Methods: Genetic analysis ...

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hrp0097p1-435 | Diabetes and Insulin | ESPE2023

Management of severe diabetic ketoacidosis with extremely high doses of insulin in a girl with severe insulin resistance syndrome due to compound heterozygous mutations in the insulin receptor gene

Kamrath Clemens , Genthner Nora , Rakicioglu Hande , Wudy Stefan

We report a girl born small for gestational age with a birth weight of 1970g. At the age of 2 years she developed marked dystrophy, height was -4.39 SDS and BMI was -3.1 SDS. Later she developed severe insulin restistance and hyperglycaemia due to compound heterozygous mutations in the insulin receptor gene: exon 16: c.2986A>G (paternal) and intron 9: c.2029+1G>T (maternal). Clinical findings included severe acanthosis nigricans, mild hypertrophic cardiomyopathy, abnorma...

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hrp0097p1-436 | Diabetes and Insulin | ESPE2023

Should the diagnostic criteria of childhood obesity depend on the nutritional status of national pediatric population? A lesson form assessment of Ukrainian children with type 1 diabetes in Poland after Russian aggression against Ukraine.

Smyczyńska Joanna , Suchowiński Michał , Kopeć Kacper , Seliga Przemysław , Olejniczak Aleksandra , Szadkowska Agnieszka

Introduction: Childhood overnutrition is a global challenge of public health. Both WHO and different countries have prepared BMI charts for pediatric population. Proper assessment of nutritional status is particularly important in children with type 1 diabetes (DM1). Due to Russian aggression, some Ukrainians with DM1 have to continue treatment in Poland.Aim: to compare HbA1 concentrations and the incidence of overnutrit...

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hrp0097p1-437 | Diabetes and Insulin | ESPE2023

Efficacy of the Tubeless Insulin Management System on Glycemic Control in Children and Adolescents with Type 1 Diabetes Previously Treated with Multiple Daily Injections and Flash Glucose Monitor Over the First 12 Weeks of Use

Elbarbary Nancy

Introduction: Assessment of real-world use of diabetes technology recently introduced in the region can provide information on clinical outcomes to help with advancement of care in a developing country like Egypt.Objectives: This prospective pilot study included patient-reported clinical outcomes on glycemic metrics in pediatric and adolescent patients with T1DM before (baseline) and 12 weeks after (follow up) the initia...

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hrp0097p1-438 | Diabetes and Insulin | ESPE2023

A qualitative study of knowledge, attitudes and perceptions of new diabetes technologies in A&E department

Alexopoulou Vasiliki , McCaffrey Liana , Mccabe Miranda , May Ng Sze

Background: In August 2022, the National Institute of Health and Care Excellence recommended that all adults and children with type 1 diabetes (T1DM) should have access to Continuous Glucose monitoring systems (CGM). This guidance will increase the number of T1DM patients who present in the A&E department and the use the new diabetes technologies in clinical practice. In addition, hybrid closed-loop (HCL) systems which integrate CGM and insulin pumps to au...

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hrp0097p1-439 | Diabetes and Insulin | ESPE2023

Determinants And Characteristics Of Insulin Dose Requirements In Children And Adolescent With New-Onset Type 1 Diabetes: Insights From The INSENODIAB Study

Beckers Maude , Lysy Philippe , Polle Olivier , Bernard Noémie , Gallo Paola

Aims: In children with new-onset type 1 diabetes mellitus (T1D), insulin dose regimens vary substantially. According to current ISPAD recommendations, the initial total daily dose (TDD) should range from 0.7 to 1.0 IU/kg BW/day. Adjusting TDD to achieve normal blood glucose concentration can take several days. The primary objectives of our INSENODIAB (INsulin SEnsitivity in New Onset type 1 DIABetes) study were to assess how patient characteristics influence i...

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hrp0097p1-440 | Diabetes and Insulin | ESPE2023

Monogenic forms of neonatal diabetes: our casuistics and evolution

Ángeles Santos Mata María , Pacheco Carrillo Aitana , Ruiz Ocaña Pablo , Macías López Francisco

Neonatal diabetes (ND) occurs in 1/100,000-150,000 newborns with hyperglycemia in the first six months of life, requiring insulin treatment for at least two weeks, with no autoimmune basis. Two forms are described, transitory (TND) and permanent (PND). In 50% cases of TND, remission presents within the first year of life, only to relapse later before puberty in 50% of cases.CASE 1: Newborn with sustained hyperglycemia since the third day of life, requiri...

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hrp0097p1-441 | Diabetes and Insulin | ESPE2023

A Case Series of Two Adolescents with HNF1B MODY and Multisystem Disorders

Vourdoumpa Aikaterini , Paltoglou George , Sertedaki Amalia , Sakou Irini-Ikbale , Karanasios Spyridon , Karavanaki Kyriaki , Charmandari Evangelia

Introduction: HNF1B gene (OMIM*189907) encodes the transcription factor HNF1B, which is expressed early in embryogenesis, controls gene expression and is involved in multiple tissue and organ development. Mutations of HNF1B account for a complex disorder with multisystemic manifestations (Renal Cysts and Diabetes syndrome, OMIM #137920). Congenital urinary tract abnormalities and HNF1B MODY, a rare cause of diabetes mellitus (DM) (≤5% of M...

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hrp0097p1-442 | Diabetes and Insulin | ESPE2023

Identification of GCK-MODY in case of neonatal hyperglycemia

Hakobyan Nina , Avetisyan Susanna , Markosyan Renata

Neonatal Diabetes mellitus (NDM) is a rare genetic disease. In this report, we presented a case of NDM due to mutation in GCK gene. A male baby born to a non-consanguineous parent at 42 weeks of gestation with a birth weight of 3.2 kg. The mother was diagnosed with gestational diabetes; no special treatment was given. The first episode of hyperglycemia was registered at the age of 13 days at hospitalization due to bronchitis /blood glucose -6.2⁓7.9 mmol/l. Due to mild h...

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hrp0097p1-443 | Diabetes and Insulin | ESPE2023

To study the prognostic significance of the molecule intercell adhesion type 1 (ICAM1 – intercellularadhesion molecule type 1, CD54) and adhesion moleculesvascular endothelium type 1 (VCAM1 - vascularcell adhesion molecule type 1, CD106) in children with type 1 diabetes mellitus after COVID 19 infection

Aripova Malika , Khaydarova Feruza , Alimova Nasiba , Alieva Anna , Sadikova Aqida

The study was aimed at assessing the relationship between increased titers of intercellular adhesion molecules ICAM VCAM in order to assess the risk of developing vascular lesions in children with type 1 diabetesIntroduction: COVID-19 induces a systemic inflammatory response, including dysregulation and misexpression of many inflammatory cytokines [1]. Inflammatory cell recruitment and activation depends on the expression of many classes...

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hrp0097p1-444 | Diabetes and Insulin | ESPE2023

From human insulin to insulin analogues: what impact on the BMI of children with type 1 diabetes?

Marzouk Asma , Laajili Mariem , Zouari Noura , Bouguila Jihene , Bouaziz ASma

Introduction:Despite the widely proven value of insulin analogs in the treatment of children with type 1 diabetes (T1D), pediatric studies of Increased weight gain in T1D are complicated by the age-dependency and gender-dependency of BMI, and also by a trend towards obesity in the general population.Objective: to assess the impact of switching from Humain Insulin (HI) to insulin analogues on the BMI of children with T1D....

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ESPE Abstracts

61st Annual ESPE (ESPE 2023)

BiosciAbstracts