Fat, Metabolism and Obesity

Background: Prader–Willi syndrome (PWS) is a rare genetic disorder associated with hyperphagia, and excessive weight gain. Patients with PWS are at elevated risk of developing morbid obesity and associated life-threatening complications. Although gut microbiota has been suggested to play a role in disease phenotypes, little is known about its composition and how it relates to hyperphagia.Objective: The aim of this ...

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hrp0097p1-51 | Fat, Metabolism and Obesity | ESPE2023

GLP1 agonists improve glycaemic dysregulation, satiety levels and quality of life in adolescents with obesity

Apperley Louise , Parkinson Jennifer , Senniappan Senthil , Patrizia Bruzzi

Introduction: GLP-1 receptor agonists (GLP1A) have been shown to be effective in achieving weight loss in adolescents with obesity and improve glycaemic control in type 2 diabetes mellitus (T2DM). We aimed to investigate the glycaemic alterations and satiety levels in patients treated with the GLP1A, liraglutide. To the best of our knowledge, this is the first study of its kind.Methods: In total, 22 patients managed in a...

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hrp0097p1-52 | Fat, Metabolism and Obesity | ESPE2023

Effects of Relaxation of COVID-19 restriction measurements on glucose and insulin metabolism in overweight and obesity youth

Matonti Lorena , Trisi Giulia , Mastromauro Concetta , Di Pietro Giada , Chiarelli Francesco , Giannini Cosimo , Mohn Angelika

Background: COVID-19 restriction measurements have determined profound alterations in glucose and insulin metabolism in children with overweight and obesity. However, to date few data have explored the effects of the relaxation of restrictions in the pediatric population. Thus, we compared anthropometric and OGTT data in children with overweight and obesity during the two years after (2021-2023) compared to the two years during (2020-2021) and before (2018-201...

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hrp0097p1-53 | Fat, Metabolism and Obesity | ESPE2023

First results from the ongoing Med4Youth European study: comparing Mediterranean diet with a Low-Fat Diet for adolescents with obesity

Petraroli Maddalena , Shulhai Anna-Mariia , Messina Giulia , Rosi Alice , Bertolotti Elena , Maria Roberta Esposito Susanna , Scazzina Francesca , Elisabeth Street Maria

Obesity is increasing, and the related complications are well known. Clinical Trials related with specific diets are currently lacking in paediatrics. There is an increasing interest in Mediterranean diet (MD). The Med4Youth European study* has enrolled 240, 13- to 16-year-old subjects with a BMI above the 90th percentile(WHO curves) in a multicenter randomized controlled trial (Italy, Spain and Portugal) to evaluate the effects of MD. We present the data relative to the 80 su...

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hrp0097p1-54 | Fat, Metabolism and Obesity | ESPE2023

Early corneal nerve fiber regeneration in children with obesity and impaired glucose tolerance treated with the GLP-1 agonist Liraglutide

Gad Hoda , Dauleh Hajar , Pasha Maheen , A. Malik Rayaz , Hussain Khalid

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists are approved for the treatment of T2DM and obesity and high dose liraglutide is FDA approved for chronic weight management in pediatric patients aged 12 and older who are obese. GLP-1R may also have a beneficial effect on the central and peripheral nervous system. Corneal Confocal Microscopy (CCM) has been used to show early nerve fiber regeneration in adults with obesity with and without diabetes....

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hrp0097p1-55 | Fat, Metabolism and Obesity | ESPE2023

Association between serum uric acid and blood pressure in children and adolescents: A systematic review-meta regression

Beng Hui Ng Nicholas , Han Luke , Tan Rachel , Ven Yap Qai , Huak Chan Yiong

Background: Hyperuricaemia has been associated with increased risk of metabolic syndrome in adults and children. Elevation in serum uric acid (SUA) is hypothesized to be a critical initiator of the development of essential hypertension. The exact relationship between SUA and blood pressure (BP) has not been established in the pediatric population. We conducted a systematic review to evaluate the association between SUA and BP in well, obese/overweight and hype...

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hrp0097p1-56 | Fat, Metabolism and Obesity | ESPE2023

Lipoma slice cultures as a new model to examine the effects of PI3K inhibitors on lipid accumulation

Maria Merz Lea , Kallendrusch Sonja , Winter Karsten , Klöting Nora , Krause Kerstin , Le Duc Diana , Kiess Wieland , Garten Antje

Introduction: PTEN hamartoma tumor syndrome (PHTS) is a rare genetic disorder caused by germline mutations in the tumor suppressor gene Phosphatase and tensin homologue (PTEN), a negative regulator of the phosphoinositide-3 kinase (PI3K)/AKT/ mechanistic target of rapamycin (mTOR) pathway. Children with PHTS frequently develop adipose tissue overgrowth, so called lipomas that can lead to loss of organ function due to displacing lipoma growth. Currently, except...

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hrp0097p1-57 | Fat, Metabolism and Obesity | ESPE2023

Trends in prevalence of overweight, obesity and severe obesity among Norwegian children from 2010 to 2022.

Balthasar Melissa , Roelants Mathieu , Brannsether-Ellingsen Bente , Benedikt Júlíusson Pétur

Aim: Data on weight status are essential to guide the development of preventive measures, which can reduce adverse consequences for health. The aim of this study was to estimate trends, from 2010 to 2022, in the prevalence of overweight, obesity and severe obesity, using the International Obesity Task Force cut-off values. Weight trends were explored in children between 2 and 14 years in the municipality of Bergen, Norway.Methods...

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hrp0097p1-58 | Fat, Metabolism and Obesity | ESPE2023

Neck circumference and metabolic score before and after long-term impact of a lifestyle intervention in patients with abdominal obesity

Azcona-Sanjulian Cristina , Ana Catalan , Ana Ojeda-Rodriguez , Chueca María , Sara Berrade , Marti Amelia

Aim: to assess and follow-up neck circumference and its relationship with a metabolic score in patients with abdominal obesity after a lifestyle intervention.Patients, Material and Methods: 122 children and adolescents with abdominal obesity, aged 7 to 16 years, were included in a control randomized intervention study (NCT031472). Abdominal obesity was diagnosed using the waist circumference. The intervention included an...

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hrp0097p1-59 | Fat, Metabolism and Obesity | ESPE2023

Diagnostic value of soluble LEPR levels in the serum of patients with disease-causing biallelic LEPR variants

Zorn Stefanie , Tews Daniel , von Schnurbein Julia , Flehmig Bertram , Pridzun Lutz , Wabitsch Martin , Malene IV , Chantana Yay , Khun Leang Chhun , Ban Manet , Tyla Martin , Ngee Lek

Introduction: The soluble leptin receptor (sLR) is the main binding protein of leptin in the serum. It reflects the amount of membrane-bound leptin receptors (LEPR) as the sLR is produced by proteolytic cleavage of the extracellular domain of membrane-bound LEPR. Low sLR but high leptin levels were measured in patients with severe obesity. In patients with monogenic obesity caused by biallelic LEPR variants, sLR levels were found to be either undetect...

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hrp0097p1-60 | Fat, Metabolism and Obesity | ESPE2023

Clinical usefulness of bioimpedance analysis in children and adolescents with severe obesity. Preliminary results of the Polish-German study project on severe early-onset obesity.

Kostrzeba Ewa , Bik-Multanowski Mirosław , Brandt Stephanie , Flehmig Bertram , Małecka-Tendera Ewa , Mazur Artur , B. Ranke Michael , Wabitsch Martin , Wójcik Małgorzata , Zachurzok Agnieszka , Petriczko Elżbieta

Aim: Childhood obesity has become extremely important issue worldwide. The aim of this study was to determine associations between data from bioimpedance analysis with the antrophometric measurements and biochemical results obtained from children and adolescents with severe obesity.Study population and Methods: Study group consisted of 128 children recruited in four regional reference centers including 70 girls (54.7%) a...

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hrp0097p1-61 | Fat, Metabolism and Obesity | ESPE2023

Incidental Sitosterolemia on Genetic testing in Saudi Youth Presenting with Bony lesions, A Case Study

Mulla Jaazeel , Aljuraibah Fahad , Aldubayee Mohammad , Alswaid Abdulrahman , Alharbi Talal

Background: Sitosterolemia, a rare autosomal recessive defect in lipid metabolism, is caused by mutations in the transporter genes ABCG5 and ABCG8 coding receptors on the luminal surface of enterocytes. Thus, hyperabsorption of non-digestible plant sterol in tissue and blood resulting in cardiovascular (CVD) sequalae. Here we report a case of Sitosterolaemia incidentally diagnosed on whole exome sequencing (WES) for bony lesions in a young Saudi girl with asym...

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hrp0097p1-62 | Fat, Metabolism and Obesity | ESPE2023

Effect of metreleptin on metabolic changes in patient with congenital generalized lipodystrophy

Rakhimzhanova Marzhan , Issabayeva Assel , Umerzakova Aigerim , Alzhaxina Alina

Background: Congenital generalized lipodystrophy is a rare and serious genetic disorder that has a profound impact on the quality of life of individuals. The worldwide prevalence of disease is estimated at 1 in 12 million people. It causes significant metabolic abnormalities and may reduce the life expectancy of children and young adults due to the late diagnosis and absence of adequate treatment. Below, we report the case of an 8-year-old boy with Berardinell...

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hrp0097p1-63 | Fat, Metabolism and Obesity | ESPE2023

The effectiveness of novel E-Health applications for the management of obesity in childhood and adolescence during the COVID-19 outbreak in Greece

Ramouzi Eleni , Koutaki Diamanto , Paltoglou Georgios , Tragomalou Athanasia , Vourdoumpa Aikaterini , Manou Maria , Kassari Penio , Tzounakou Anastasia , Charmandari Evangelia

Background: The prevalence of childhood obesity has recently increased, particularly during the COVID-19 pandemic, which has led to lifestyle changes as a result of public health regulations and guidelines introduced by governments worldwide.Objective: To investigate the effectiveness of novel e-Health applications in addressing childhood obesity prior to and during the Covid-19 outbreak.Pa...

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hrp0097p1-64 | Fat, Metabolism and Obesity | ESPE2023

Abstract withdrawn...

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hrp0097p1-65 | Fat, Metabolism and Obesity | ESPE2023

Natural history of corpulence in patients carrying heterozygous pathogenic variants in the five major genes of the leptin-melanocortin pathway.

Nicaise Clarisse , Dubern Béatrice , Poitou Christine , Clement Karine , Tounian Patrick , Lemale Julie , COURBAGE Sophie , Le Bihan Johanne

Introduction: The leptin-melanocortin pathway plays a key-role in weight control. Pathogenic variants in the five major genes (LEP, LEPR, POMC, PCSK1, MC4R) are associated with early severe obesity. However, the specific associated phenotype with presence of mono-allelic variants and especially BMI trajectories are not well known.Objective: In order to identify specific profiles, we compared BMI trajectories during the f...

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hrp0097p1-66 | Fat, Metabolism and Obesity | ESPE2023

Leptin treatment affects adipose progenitor cells physiology

Jasaszwili Mariami , Fuchs Lasse , Richter Sandy , Kirstein Anna , Kiess Wieland , Le Duc Diana , Garten Antje

Introduction: Leptin, an adipokine secreted mainly by adipose tissue, is a regulator of energy balance acting through central mechanisms on the hypothalamus. However, leptin has many functions regulating e.g., immune system and reproduction. Leptin exerts its biological effects through its receptor, the expression of which has been demonstrated in several tissues. There are several leptin receptor isoforms, but activation of only one of them, the long form, re...

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hrp0097p1-67 | Fat, Metabolism and Obesity | ESPE2023

Percentage of Appendicular Skeletal Muscle Mass Reference and Association with Metabolic Syndrome in Korean Adolescents

Hye Lee Da , Kang Sung-Chan , Hwang Seung-sik , Jeong Lee Yun , Young Kim Hwa , Yong Lee Seong , Ho Shin Choong , Kim Jaehyun

Purpose: The association between appendicular skeletal muscle mass (ASM) and cardiometabolic risk has been emphasized. We estimated reference values of the percentage of ASM (PASM) and investigated its association with metabolic syndrome (MS) in Korean adolescents.Methods: Data from Korea National Health and Nutrition Examination Survey performed between 2009 and 2011 was used. Tables and graphs of reference PASM were ge...

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hrp0097p1-68 | Fat, Metabolism and Obesity | ESPE2023

The association of triglyceride glucose-body mass index with transient elastography in pediatric non-alcoholic fatty liver disease

Tae Hwang Il , Young Kim Eun

Background: Triglyceride glucose (TyG) index combined with body mass index (BMI) were reported to be superior to TyG index alone in predicting non-alcoholic fatty liver disease (NAFLD) in youths. Transient elastography (TE) uses pulsed echo ultrasound to measure the hardness of the liver, showing excellent accuracy in the assessment of fibrosis, and is considered a useful test in NAFLD. Objects: This study aims to investigate the association between TyG-BMI an...

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hrp0097p1-69 | Fat, Metabolism and Obesity | ESPE2023

Difference of nafld frequency between younger and older children with obesity

Stanikova Daniela , Vitariusova Eva , Kosnacova Jana , Cierna Iveta , Stanik Juraj

Background: Non-alcoholic Fatty Liver Disease (NAFLD) is a frequent complication of obesity in both adults and children and there is an alarming increase in prevalence of both. Studying of risk factors for NAFLD in children and adolescents might help to select vulnerable groups to start an early intervention.Objectives: The aim of our study was to detect the prevalence of NAFLD in pediatric obese patients (0-18.9 years, ...

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hrp0097p1-70 | Fat, Metabolism and Obesity | ESPE2023

Association of Serum Uric Acid Levels with Metabolic Syndromes in Children and Young Adolescents

Suk Shim Young , Seo Young-Jun , Sang Lee Hae , Rim Jeong Hwal , Sub Lim Jung , Soon Hwang Jin

Purpose: We investigated uric acid reference values and their association with cardiometabolic risk among children and adolescents using the Korea National Health and Nutrition Examination Survey (KNHANES).Methods: A total of 2,462 participants, aged 10-18 years, from the KNHANES 2016-2018 were included.Results: Serum uric acid (SUA) levels varied with sex and age. In male subjects...

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hrp0097p1-71 | Fat, Metabolism and Obesity | ESPE2023

Obesity prevalence and gender incongruence – Results from a systematic literature review

Winner Kay , Brandt Stephanie , Wabitsch Martin

Introduction: Elevated obesity prevalence among transgender individuals compared to cisgender control groups or general population have been reported in some studies. Whether there is a higher prevalence for obesity in transfeminine and transmasculine persons at different age groups has not yet been systematically studied.Methods: We performed a systematic literature search using Pubmed and Google Scholar. Following sear...

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hrp0097p1-72 | Fat, Metabolism and Obesity | ESPE2023

GLP-1 analogues in therapy of obese adolescents. Early real-life experience with liraglutide treatment

Krenek Malikova Jana , Lebl Jan

Introduction: GLP-1 analogues are promising agents for the pharmacotherapy of obesity due to their combined effect on metabolic signalization and eating behavior. The GLP-1 analog liraglutide is registered in Europe for therapy of obese adolescents aged 12-17 years since 2021. According to clinical studies, liraglutide administration leads to a mean weight loss 4.6%. We summarize early real-life experience with this novel therapy.<strong...

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hrp0097p1-73 | Fat, Metabolism and Obesity | ESPE2023

Insulin as a treatment modality for familial chylomicronemia syndrome in resource-limited settings- A Case series

Jebaseeli Hoole Thabitha , Suntharesan Jananie , Jayasundara Imalka , Siriwardne Dinendra , Naotunna Chamidri , Jasinghe Eresha , Atapattu Navoda

Introduction: Familial chylomicronemia syndrome (FCS) is an extremely rare monogenic disease with a prevalence of 1-2:1,000,000. Defects in lipoprotein lipase (LPL) are the main cause. Recurrent acute pancreatitis is a life-threatening complication of FCS. Insulin therapy is known to be a mode of treatment for hypertriglyceridemia.Case series: We present four children with genetically confirmed LPL deficiency followed up...

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hrp0097p1-74 | Fat, Metabolism and Obesity | ESPE2023

A novel mutation of leptin gene in two siblings with early onset obesity

Deodati Annalisa , amodeo mariaelisa , mirra giulia , pampanini valentina , cianfarani stefano

Background: Congenital leptin deficiency is a rare cause of early-onset severe obesity. Clinical features of congenital leptin deficiency include early-onset severe obesity, marked hyperphagia, endocrine and metabolic alterations. Some patients have immune dysregulation.Case report: We describe two siblings from Libya referred for severe obesity. A boy (patient 1) referred at the age of 4 years and 3 months and a girl (p...

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hrp0097p1-75 | Fat, Metabolism and Obesity | ESPE2023

Newer anthropometric indexes predicting insulin resistance in Greek children and adolescents with overweight and obesity

Giza Styliani , Ntouma Stergianna , P Kotanidou Eleni , Rengina Tsinopoulou Vasiliki , Kampani Eleftheria , I Sakellari Eleni , Galli-Tsinopoulou Assimina

Introduction: Body mass index (BMI) and waist circumference (WC) are the main anthropometric measures of obesity. However, their inability to take into account body fat distribution raises queries for their predictive value of insulin resistance (IR) in youth.Aim: The aim of this study is to compare BMI and WC with latest anthropometric indices in the assessment of IR in a paediatric Greek population with overweight and ...

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hrp0097p1-76 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of Clinical Characteristics of Patients Diagnosed with Syndromic Obesity

Özalp Kızılay Deniz , Gül Balkı Hanife , Arslan Emrullah , Turkut Tan Türkan , Jalilova Arzu , Işık Esra , Gökşen Damla , Darcan Şükran , Özen Samim

Keywords: Syndromic Obesity, Child, GeneticsObjective: Syndromic obesity is accompanied by dysmorphic findings, motor and mental retardation, and organ anomalies. In this study, we aimed to evaluate the patients who were followed up with a diagnosis of syndromic obesity in our clinic.Materials and Methods: Demographic, clinical, and biochemical data of the patients followed up betwee...

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hrp0097p1-77 | Fat, Metabolism and Obesity | ESPE2023

Association between Steroid Therapy and Lipid Profiles in Children with Chronic Disease

Mayasari Lubis Siska , Deliana Melda

Background: Steroid is a standard treatment for several chronic diseases in children, such as autoimmune or rheumatology disease. However, despite its benefit, steroids have many side effects, including dyslipidemia. Dyslipidemia in childhood increases the risk of atherosclerosis development that can progress into cardiovascular disease. Dyslipidemia is diagnosed using the lipid profile of the patient. The aim of this study was to determine the association bet...

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hrp0097p1-78 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of Τri-Ponderal Mass Index as a reflector of adiposity among pediatric cancer survivors

P Kotanidou Eleni , Rengina Tsinopoulou Vasiliki , Giza Styliani , I Sakellari Eleni , Douma Stergianna , Antari Vasiliki , Palampougiouki Maria , Ioannidou Maria , Tragiannidis Athanasios , Hatzipantelis Emmanouil , Galli-Tsinopoulou Assimina

Objectives: Modern treatments lead to increased survival rates from childhood cancer. Childhood cancer survivors (CCS) are a growing population group, which is at high risk for cardiometabolic disorders including metabolic syndrome, type 2 diabetes and cardiovascular disease. Obesity is one of the major drivers of these adverse outcomes, resulted from corticosteroids, radiotherapy, sedentary behavior, and precancer obesity. Assessment of obesity could identify...

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hrp0097p1-79 | Fat, Metabolism and Obesity | ESPE2023

Features of exogenous-constitutional obesity in children and adolescents of the Uzbek population depending on age.

Rakhimova Gulnara , Azimova Shaxnoza , Alimova Nasiba , Egamberdieva Maftuna , Siddikov Abdulbosit

Objective of The Study: To study the characteristics of carbohydrate and lipid metabolism in obese children and adolescents depending on the age.Materials and Methods: We examined 171 children and adolescents aged from 6 to 16. Among them, there were 100 children and adolescents with ECO and 71 healthy children and adolescents. ECO patients were divided into 2 groups: group 1 including children with ECO aged 6-<10 yea...

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hrp0097p1-80 | Fat, Metabolism and Obesity | ESPE2023

Leukocyte, platelet counts and the neutrophil-to-lymphocyte ratio (NLR) are related to insulin resistance in obese and overweight children

Lauriola Federico , Mastromauro Concetta , Mascioli Ilaria , Chiarelli Francesco , Mohn Angelika , Giannini Cosimo

Background and aims: The development of insulin resistance (IR) may be influenced by inflammation in overweight/obese individuals. To identify indicators of IR, new markers of inflammation and systemic inflammation such as leukocyte (WBC) and platelet counts (PLT), the neutrophil-to-lymphocyte ratio (NLR) have been suggested. This study aims to investigate the association between these markers and IR in a group of overweight and obese.<s...

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hrp0097p1-81 | Fat, Metabolism and Obesity | ESPE2023

Comparison of HbA1c and OGTT for the identification of type 2 diabetes in obese children above 10 years of age.

A. M. Dimarsha de Silva U. , Askin Shereen , Jayamanne Bdw , Atapattu Navoda

Background: Childhood obesity is a growing global problem that linked with health issues including type II diabetes. Early screening and diagnosis using OGTT and/or HbA1c of obese children is recommended in order to minimize type II diabetic risk. OGTT requires fasting and two venesections impeding the child’s compliance. In contrast, hemoglobin A1c (HbA1c) is a convenient test and evaluation of HbA1C as a diagnostic tool of type II diabetes in the obese...

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hrp0097p1-82 | Fat, Metabolism and Obesity | ESPE2023

Leptin receptor’s mutation in a patient with childhood obesity and hyperphagia

Partenope Cristina , Dondi Elena , De Marchi Irene , Antoniotti Valentina , Monteleone Giorgia , Bianco Carlo , Montafia Ilaria , Pagliero Federica , Aquisti Giulia , Petri Antonella , Rabbone Ivana , Prodam Flavia , Bellone Simonetta

Introduction: Genetic factors play an important role in determining individual susceptibility to weight gain and obesity. In the last few years, several genetic variants have been identified as monogenic forms of obesity. Among them, Leptin (LEP) and its receptor on hypothalamic neurons (LEPR) are key players in the regulation of body weight, food intake and energy homeostasis. Pathogenic variants in the LEPR gene cause severe childhood-onset obesity with an a...

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hrp0097p1-83 | Fat, Metabolism and Obesity | ESPE2023

Improvement in Health-Related Quality of Life scores in Children and Young people with Obesity following intervention and support from a Tertiary MDT Weight Management Service

Ramya Gokul Pon , Apperley Louise , Parkinson Jennifer , Clarke Ellie , Gubaeva Diliara , Clark Kate , Lund Kim , Owens Meghan , Senniappan Senthil

Introduction: Obesity is a significant public health concern affecting children and young people (CYP) worldwide. The impact of obesity on CYP is multi-faceted and can have a significant effect on their lives. They are at risk of being stigmatized and discriminated against, leading to poor academic performance and social functioning. It is crucial to assess the impact of obesity on the lives of CYP through tools such as Health-related quality of life (HRQOL) q...

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hrp0097p1-246 | Fat, Metabolism and Obesity | ESPE2023

Obesity Caused by Mutations in the Melanocortin 4 Pathway: Experience From a Teaching Hospital

Gupta Sanjay , Dalpathadu Sanjalee , Mathew Verghese , Greetham Sandra

Introduction: The role of genetics in obesity is a much under discussed area. Whilst it is undeniable that environmental factors play a major role in obesity in most cases, there is a small proportion of cases where genetic mutations are the main underlying cause. This includes novel monogenic conditions involving mutations in the Melanocortin-4 receptor (MC4R) signalling pathway. In a healthy individual, the post-meal increase in leptin (LEP) stimulates melan...

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hrp0097p1-247 | Fat, Metabolism and Obesity | ESPE2023

Th17 lymphocytes and peripheral complete blood count alterations in obese children

Artemniak-Wojtowicz Dorota , M. Kucharska Anna , Stelmaszczyk-Emmel Anna , Majcher Anna , Rumińska Małgorzata , Pyrżak Beata

Introduction: Obesity is considered one of the most common chronic diseases worldwide which is associated with chronic, low-grade, sterile inflammation. It leads to variable changes in metabolic and hormonal homeostasis. The aim of our study was to evaluate the impact of obesity associated chronic inflammation on peripheral complete blood count alterations.Material and Methods: 27 overweight/obese and 15 normal-weight ch...

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hrp0097p1-248 | Fat, Metabolism and Obesity | ESPE2023

Single Gene Variations in Etiology in Children with Severe Obesity

Kahveci Ahmet , Kelestemur Elif , Kurt Ilknur , Guran Tulay , Turan Serap , Bereket Abdullah , Haliloglu Belma

Background: Obesity is a multifactorial disease caused by environmental and genetic factors. Single gene defects explain approximately 5-13% of early-onset obesity and these rates vary according to genetic panel used and the rate of consanguinity in the population studied. As the new treatment modalities emerge for monogenic obesity, it is important to identify the molecular etiology of obesity.Materials and Methods: Buc...

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hrp0097p1-249 | Fat, Metabolism and Obesity | ESPE2023

Association of chemokine network profile with albuminuria in obese children

Spehar Uroic Anita , Filipovic Masa , Krnic Nevena , Sucur Alan , Grcevic Danka

Childhood obesity has increased in epidemic proportions worldwide. Complications of obesity represent a growing proportion of childhood morbidity. Albuminuria resulting from endothelial damage was recognized as a complication of obesity, implying higher cardiovascular risk.Aim: to investigate the association of albuminuria in obese children with metabolic and inflammatory parameters.Materials and Methods:</...

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hrp0097p1-250 | Fat, Metabolism and Obesity | ESPE2023

Sitosterolemia – An underdiagnosed and heterogeneous lipid disorder. A Case Series from The Children’s Hospital at Westmead NSW Australia.

Gamage Dilhara , Chisholm Kerryn , Srinivasan Shubha

Background: Sitosterolaemia, or phytosterolaemia, is a disorder of increased plant sterol levels in the body leading to a variable presentation including hypercholesteremia, xanthoma, atherosclerosis and haematological manifestations. Although considered rare, the prevalence is likely underestimated due to the variable phenotype. It is caused by recessively inherited mutations in ABCG5 or ABCG8 which encode the sterol efflux transporters in the gut. Hyperchole...

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hrp0097p1-251 | Fat, Metabolism and Obesity | ESPE2023

Overweight and obesity in childhood and adolescence is associated with an increased fracture risk - Results of a systematic literature review

Brandt Stephanie , Schroth Viola , Wabitsch Martin

Introduction: Up to now, no systematic literature review has studied whether overweight or obesity compared to normal weight in childhood and adolescence is associated with an increased fracture risk (fractures overall and by site).Methods: The systematic literature search was conducted in PubMed/Medline, Embase, Cochrane Library, BIOSIS databases using defined keywords and MeSH terms. 1,677 publications were identified ...

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hrp0097p1-252 | Fat, Metabolism and Obesity | ESPE2023

Dietary and physical activity habits of children and adolescents after a personalized intervention for the management of obesity

Ioannou Georgia , Petrou Ioulia , Manou Maria , Papadopoulou Marina , Tragomalou Athanasia , Kassari Penio , Charmandari Evangelia

Introduction: Obesity in childhood and adolescence has been recognized by the WHO as a global epidemic and a major public health problem. Greece, is one of the main countries in Europe where the problem of childhood obesity has increased rapidly. This rise can be attributed to dietary and physical activity risk factors. Recently, there has been a need for a detailed recording and assessment of the lifestyle habits of children and adolescents receiving personal...

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hrp0097p1-253 | Fat, Metabolism and Obesity | ESPE2023

Effect of growth hormone on thermogenic and endocrine activity of brown adipose tissue and on the lipidome of children born small for gestational age

Murillo-Vallés Marta , González-López Lorena , Valls-Llussà Aina , González-Riaño Carolina , Cereijo-Tellez Rubén , Jimenez-Pavón David , Barbas Coral , Villarroya Francesc , Sánchez-Infantes David

Introduction: Brown adipose tissue (BAT) secretes molecules capable of modulating systemic metabolism. Growth hormone (GH) has hyperglycemic action, produces lipolysis and increases muscle mass. However, there are no human studies on its effect on the BAT and lipidome.Aim: To evaluate the effect of GH on BAT and lipidome in small for gestational age (SGA) patients and its relationship with adherence to treatment.<p c...

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hrp0097p1-254 | Fat, Metabolism and Obesity | ESPE2023

The early identification of glycaemic dysregulation with the use of continuous glucose monitoring in children and young people with obesity

Apperley Louise , Parkinson Jennifer , Senniappan Senthil

Introduction: Impaired glucose tolerance and type 2 diabetes mellitus are known complications associated with childhood obesity. At present, an oral glucose tolerance test (OGTT) is the gold standard investigation. Continuous glucose monitors (CGM) are used in children and young people (CYP) with type 1 diabetes mellitus. The aim of our study is to investigate whether the use of a CGM is more effective in identifying glycaemic dysregulation, compared to an OGT...

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hrp0097p1-255 | Fat, Metabolism and Obesity | ESPE2023

Comparison of triglyceride-glucose index and HOMA-IR for predicting severity of nonalcoholic fatty liver disease in Korean children and adolescents

Young Kim Eun , Tae Hwang Il

Background: Triglyceride-glucose (TyG) index is known as a reliable insulin resistance surrogate marker to identify non-alcoholic fatty liver disease (NAFLD). Ultrasonographic fatty liver indicator (US-FLI) is proposed as a non-invasive, semi-quantitative method for predicting hepatitis in patients with NAFLD and accurately identifies histological severity. Few studies have compared the TyG index to homeostasis model assessment of insulin resistance (HOMA-IR) ...

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hrp0097p1-256 | Fat, Metabolism and Obesity | ESPE2023

Serum leptin concentrations in a pooled cohort of 6.105 children and adolescents: Reference values as a function of dependence on sex, age, pubertal stage and BMI-SDS

Brandt Stephanie , Vogel Mandy , Kratzsch Jürgen , Tews Daniel , Pridzun Lutz , Flehmig Bertram , B Ranke Michael , Körner Antje , Kiess Wieland , F Blum Werner , Wabitsch Martin

Background: Current reference values for leptin in childhood and adolescence are presented separately for girls and boys, and as a function of age without considering the variability of fat mass. This complicates the interpretation of measured serum leptin concentrations since fat mass is the major determinant of circulating leptin concentrations. To fill this gap, we aimed at pooling existing data (age, BMI, sex, tanner stage (TS), serum leptin concentrations...

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hrp0097p1-257 | Fat, Metabolism and Obesity | ESPE2023

Risk Factors for becoming adult with obesity in survivors of childhoodcancer

Delacourt Laurene , Allodji Rodrigue , Chappat Juliette , Haddy Nadia , El-Fayech Chiraz , Demoor-Goldschmidt Charlotte , Journy Neige , Bolle Stephanie , Thomas-Teinturier Cécile , Zidane Monia , Rubino Carole , Veres Cristina , Vu-Bezin Giao , Berchery Delphine , Pluchart Claire , Bondiau Pierre-Yves , Dumas Agnès , Bougas Nicolas , Grill Jacques , Dufour Christelle , Fresneau Brice , Pacquement Helene , Diallo Ibrahima , Doz François , De Vathaire Florent

Purpose: The aim of this study was to identify risk factors for adult obesity in childhood solid cancer or lymphoma survivors (CCS).Patients and Methods: The study included 3199 patients of the French Childhood Cancer Survivor Study Cohort (FCCS) with 303 obese patients who had returned self-questionnaire. Analyses were adjusted on social deprivation index and sex.Results: CCS bein...

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hrp0097p1-258 | Fat, Metabolism and Obesity | ESPE2023

An interesting case of combined familial hyperlipidaemia and high lipoprotein (a) in a 20-month-old girl

Karabouta Zacharoula , Simeoforidou Elpida , Georgoulia Konstandina , Koniari Eleni , Bisbinas Alexia , Chrousos George

Introduction: Familial hypercholesterolaemia(FH) is a genetic disorder affecting approximately 1 in 250 people, resulting in high levels of low-density lipoprotein Cholesterol(LDL-C), increasing the likelihood of developing cardiovascular disease(CVD) at a younger age. Lipoprotein (a)(Lp(a)) is another risk factor for atherosclerosis, elevated in 20-25% of people and 90% genetically determined, only slightly reduced by diet, exercise and medication.<p clas...

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hrp0097p1-259 | Fat, Metabolism and Obesity | ESPE2023

Exploring the Relationship between Muscle-to-Fat Ratio and Surrogate Markers of Nonalcoholic Fatty Liver Disease in Children with Overweight and Obesity

Uretzky Adi , Zaitoon Hussein , Ben Simon Asaf , Cohen-Sela Eyal , Yackobovitch-Gavan Michal , Midlij Eyas , Borger Ophir , Interator Hagar , Amir Achiya , Moran-Lev Hadar , Brener Avivit , Lebenthal Yael

Background: We previously reported on the strong predictive value of the muscle-to-fat ratio (MFR) z-score in the development of early-onset metabolic syndrome components in children with overweight/obesity. Data on the role of the balance between muscle and fat in the development of childhood onset nonalcoholic fatty liver disease (NAFLD) are sparse. In the current study we explored the interplay between MFR and surrogate markers of NAFLD in children with ove...

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hrp0097p1-260 | Fat, Metabolism and Obesity | ESPE2023

Early onset obesity due to Melanocortin 4 receptor (MC4R) defect; Successful treatment with Semaglutide

Ramya Gokul Pon , Apperley Louise , Parkinson Jennifer , Seniappan Senthil

Introduction: Childhood obesity is a growing concern worldwide, and it has been linked to several nutritional and genetic factors. In some patients, monogenic causes can be identified, which are due to single gene mutations in specific pathways related to appetite regulation. One of the most common monogenic causes of obesity is heterozygous mutations in Melanocortin 4 receptor (MC4R), with a prevalence ranging from 2% to 6% in juvenile-onset obesity. We repor...

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hrp0097p1-261 | Fat, Metabolism and Obesity | ESPE2023

Decreased physical fitness in children is associated with increased cardiovascular risk determined by increased carotid intima-media thickness

Drole Torkar Ana , Plesnik Emil , Dovc Klemen , Jazbinsek Soncka , Mlinaric Matej , Groselj Urh , Battelino Tadej , Starc Grogor , Kotnik Primoz

Background: Early vascular aging is driven by modifiable lifestyle risk factors, including physical inactivity. Early identification of children at risk of atherosclerosis (AS) is needed for implementing primary preventive measures addressing vascular health. The aim of the study was to determine the association between objectively determined physical fitness (PF) and carotid intima-media thickness (cIMT), used as a reliable noninvasive biomarker of AS in a po...

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hrp0097p1-262 | Fat, Metabolism and Obesity | ESPE2023

16p11.2 microdeletion: a common copy number variation (CNV) identified in a Portuguese pediatric cohort with syndromic obesity.

Rosmaninho-Salgado Joana , B. Sousa Sergio , M. Pires Luis , Ferreira Susana , B. Melo Joana , M. Carreira Isabel , M. Saraiva Jorge

Background: 16p11.2 microdeletion is most common chromosomal anomaly associated with syndromic obesity. The presence of a large number of flanking segmental duplications/low-copy repeat sequences with a high degree of sequence identity in the short arm of chromosome 16 (16p) leads to recurrent deletions and duplications as a consequence of non-allelic homologous recombination. A recurrent 600kb microdeletion is one of the most frequent genomic imbalances in 16...

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hrp0097p1-263 | Fat, Metabolism and Obesity | ESPE2023

Evaluating genotype-phenotype relations in pediatric obesity: a single centre experience.

Giordano Benedetta , Caporotondi Benedetta , Susca Francesco , Napoli Flavia , Fava Daniela , Casalini Emilio , Pistorio Angela , Tantari Giacomo , Camia Tiziana , d'Annunzio Giuseppe , Maghnie Mohamad

Background: Childhood-onset obesity is a multifactorial disease with a lifelong health burden. In many cases, obesity is the result of the interaction between genetic predisposition and environmental factors. Aim of our study was to define phenotypic features of obese children and adolescents and to find possible associations between clinical phenotype and genetic variants.Patients and Methods: We recruited obese childre...

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hrp0097p1-264 | Fat, Metabolism and Obesity | ESPE2023

Implementation of the EOSS-P Risk Scale in children and adolescents living with obesity

Gonzalez Diego , Rodriguez Roberto , Garibay-Nieto Nayely , Villanueva-Ortega Eréndira , Aguilar-Cuarto Karina , Pedraza Karen , Fuentes Zendy , Ruiz Alejandra , María Hernandez Ana , Prado Edith , Ruiz Arturo

Body Mass Index (BMI) has a high association with body fat percentage and direct association with a higher degree of comorbidities. Categorizing patients only by the degree of obesity, as has been done over time, restricts the possibility of detecting and giving timely treatment to other aspects. The Edmonton Obesity Staging System for Pediatrics (EOSS-P) has been proposed as a tool to categorize obesity not only by BMI, but also by assessing metabolic complications, functiona...

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hrp0097p1-265 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of Clinical and Genetic Characteristics of Non-Syndromic Monogenic Obese Patients

Özalp Kızılay Deniz , Durmaz Asude , Arslan Emrullah , Jalilova Arzu , Gül Balkı Hanife , Aykut Ayça , Gökşen Damla , Darcan Şükran , Özen Samim

Keywords: Non-syndromic obesity, single gene disorder, child.Objective: This study aimed to evaluate the clinical characteristics, molecular genetic analysis results, and obesity-related comorbidities of patients with non-syndromic monogenic obesityMaterials and Methods: The results of a targeted next-generation sequence analysis panel (Clinical Exome Solution v2 - SOPHiA GENETICS)...

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hrp0097p1-266 | Fat, Metabolism and Obesity | ESPE2023

Abdominal fat measured with nutritional ultrasound as a risk screening for non-alcoholic hepatic steatosis (NASH) in obese children

Diez-Lopez Ignacio , Sarasua-Miranda Ainhoa , Maeso Mendez Sandra , Garcia Casares Zuriñe , Erika Calvo Saez A

NASH is an increasingly relevant finding in the pediatric population affected by obesity. In adults, its evolution from this steatosis to fibrosis and its correlation with metabolic syndrome is increasingly significant. The existence of a rapid and validated screening tool in consultation would be very useful.Main objective: To evaluate if the measurement of intraperitoneal fat measured through nutritional ultrasound, allows the diagnosi...

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hrp0097p1-267 | Fat, Metabolism and Obesity | ESPE2023

Seven Years Follow Up of a Child with Familial Chylomicronemia Syndrome: Disease Course and Effectiveness of Gemfibrozil Treatment: Case Report and Literature Review.

Mustafa Manal , Almheiri Mira

Keywords: Hypertriglyceridemia; Familial Chylomicronemia Syndrome; GemfibrozilBackground: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disease affecting lipoprotein metabolism. The condition is characterized by hypertriglyceridemia, which may predispose patients to acute pancreatitis. FCS is estimated to occur in 1 in 1 - 2 million individuals [1] and can be diagnosed at any age, affecting all ge...

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hrp0097p1-268 | Fat, Metabolism and Obesity | ESPE2023

The 2016–2021 Korea National Health and Nutrition Examination Survey for Metabolic Alteration in children and adolescent during the COVID-19 Pandemic

Kim Min-Ji , Kim Minji , Yoo Sukdong , Kun Cheon Chong

Purpose: Since the COVID-19 outbreak, the number of obese children and adolescents has increased rapidly. Obesity acts as a gateway to chronic adult diseases, so proper management during childhood and adolescence is essential. We aimed to identify the interannual changes in the prevalence of obesity, diabetes mellitus, dyslipidemia, and hypertension, and to investigate factors contributing to these changes before and during the COVID-19 pandemic.<p class="...

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hrp0097p1-269 | Fat, Metabolism and Obesity | ESPE2023

Impact of bariatric surgery on obesity complications in children and adolescents: Evaluation of a large cohort within a specialized French obesity center

Mosser Camille , Dagher Ibrahim , De Filippo Gianpaolo , Thebaut Alice , Linglart Agnès , Lambert Anne-Sophie

Summary: Severe obesity with various complications is a growing public health problem in childhood. Due to the lack of available hygienic and dietary therapeutic solutions, bariatric surgery has become, in recent years, one of the only effective treatments for severe obesity to induce persistant weight loss and reduce complications.Material and method: We analyzed a cohort of 162 patients followed in the specialized obes...

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hrp0097p1-270 | Fat, Metabolism and Obesity | ESPE2023

MC4R deficiency in a portuguese pediatric cohort study

C Mendes Ariana , Pereira Janet , Mirante Alice , M Saraiva Jorge , R. Soares Ana , B. Sousa Sérgio , Rosmaninho-Salgado Joana

Background: Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of non-syndromic obesity. MC4R is a seven transmembrane G-protein coupled receptor implicated in central regulation of body weight. The loss-of-function mutations in MC4R gene will contribute to early-onset obesity associated with hyperinsulinemia, hyperphagia and “binge eating”. We aim to determine the prevalence of MC4R variants in a Pediatrics...

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hrp0097p1-271 | Fat, Metabolism and Obesity | ESPE2023

Investigation of LDL Cholesterol in Children from Seiiku Cohort for Children and Mothers

Doi Hibiki , Yoshii Keisuke , Naiki Yasuhiro , Horikawa Reiko

Background: LDL cholesterol (LDL-C) levels can be high in familial hypercholesterolemia or other dyslipidemia, and the elevated levels are often found in the pediatric setting.Objective: To create a pediatric reference using data of a prospective birth cohort study at our hospital (Seiiku Cohort for Children and Mothers) and to examine its association with possible predisposing factors.Resu...

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hrp0097p1-272 | Fat, Metabolism and Obesity | ESPE2023

Various clinical manifestations found in 3 cases with Progeria syndrome

Igarashi Mizuho , Ota Tomoko , Doi Hibiki , Kashima Takemoto , Kosaki Rika , Yoshii Keisuke , Naiki Yasuhiro , Horikawa Reiko

Background: Progeria syndromes caused by LMNA gene variants consist of Hutchinson-Gilford progeria syndrome (HGPS) and Atypical progeroid syndrome (APS). Various phenotypes of APS are previously reported, whereas HGPS shows relatively unique phenotype.Objective: To investigate the spectrum of clinical manifestations in three cases of Progeria syndrome.Methods: The history ...

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hrp0097p1-273 | Fat, Metabolism and Obesity | ESPE2023

Congenital Leptin Receptor deficiency: A Novel LEPR gene mutation (LEPR):c.1752G>A (p.Lys584=) in an Indian family producing severe early onset monogenic obesity

Patil Prashant , Monterio Joewin

Introduction: Congenital deficiency of the leptin receptor is an extremely rare cause of early-onset monogenic obesity with rapid weight gain and compulsive overeating. LEPR mutations is responsible for extreme form of obesity associated with other endocrine abnormalities and respiratory tract infection. Till date, approximately 50 families have been reported to have mutations in the leptin receptor gene.Case: 9-year-old...

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hrp0097p1-274 | Fat, Metabolism and Obesity | ESPE2023

Breakfast skipping is associated with poor diet quality in children with overweight/obesity

Androutsos Odysseas , Tsiampalis Thomas , Georgiou Alexandra , Manou Maria , I. Kosti Rena , Charmandari Evangelia

Introduction: Daily breakfast consumption is recommended as part of a healthy lifestyle in children and adolescents. The present study aimed to report the frequency of breakfast consumption and explore the associations between breakfast consumption and diet quality in children with overweight/obesity.Methods: In total, 1335 children/adolescents 2-18 years old were recruited in a weight-management out-patient clinic in th...

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hrp0097p1-275 | Fat, Metabolism and Obesity | ESPE2023

Child with AR sitosterolemia with no hematological manifestations.

Alkhalaf Abeer , Aldubayee Mohammed , Alzaben Abdullah

Sitosterolemia is an autosomal recessive disorder affecting lipid metabolism which is characterized by decreased biliary excretion and increased absorption of plant sterols and cholesterol, leading to significantlyelevated serum levels of plant sterols. Approximately 80 homozygous or compound heterozygous variants in adenosine triphosphate-binding cassette subfamily G genes (ABCG5/ABCG8) genes have been described in patients with genetically confirmed sitosterolemia. Clinicall...

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hrp0097p1-276 | Fat, Metabolism and Obesity | ESPE2023

A novel mutation in LPL gene in two Brazilian children with familial chylomicronemia syndrome

Scheidemantel Aline , Nesi-França Suzana , Ângela Ramires De Carvalho Julienne , Teixeira Benevides Fernanda , Bento Radominski Rosana , Eduardo Cruvinel Pinto Luís , Junqueira Soares Gabriel , Cardoso-Demartini Adriane

Case Report: Patient 1: a 3.6-yr-old girl presented with very severe hypertriglyceridemia (serum triglyceride level >1000mg/dL) in random sampling in the first year of life. She presented with recurring episodes of abdominal pain, and splenomegaly. There is no history of consanguineous marriage. Maternal and paternal family had history of coronary events at an early age. A genetic panel showed homozygous variant chr8:19.953.365 C>T (p.Ala162Val) in the l...

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hrp0097p1-445 | Fat, Metabolism and Obesity | ESPE2023

Impact of early-life overweight/obesity trajectory on insulin resistance at age 8: a prospective cohort study

Jin Lee Hye , Jeong Lee Yun , Lim Youn-Hee , Hong Yun-Chul , Ho Shin Choong , Ah Lee Young

Objective: To investigate whether the early-life overweight/obesity trajectory from ages 2, 4, to 8 affects insulin resistance (IR) in 8-year-old prepubertal children.Methods: From the Environment and Development of Children (EDC) cohort, 262 prepubertal children (147 boys and 115 girls) who visited Seoul National University Children’s Hospital for anthropometric measurements at ages 2, 4 and 8 were included. At ag...

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hrp0097p1-446 | Fat, Metabolism and Obesity | ESPE2023

The evolution of diagnosis and care over time in children with Prader-Willi syndrome, born between 2005 and 2021, included in the French database.

Faye Sandy , Molinas Catherine , Brochado Cathy , Valette Marion , Desprez Clémence , Diene Gwenaelle , Arnaud Catherine , Tauber Maithé

Introduction: The French Reference Centre PRADORT set up a national Access® database in 2005 for children diagnosed with Prader-Willi Syndrome (PWS). The medical, socio-demographic and family data of 813 patients were then collected.Method: We aim to analyse the evolution of diagnosis and care over time, according to the birth year of patients by comparing 3 groups (patients born between 2005 to 2009, 2010 to 2014 an...

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hrp0097p1-447 | Fat, Metabolism and Obesity | ESPE2023

A comparison of the usefulness of two indices of insulin resistance: IRIHOMA (calculated from fasting glucose and insulin values) and IRIBelfiore (calculated from OGTT results) in diagnosis of metabolic complications and determining indications for possible dietary or pharmacological treatment in children

Łupińska Anna , Kolasa-Kicińska Marzena , Jeziorny Krzysztof , Smalczewska Paula , Rajewska Sylwia , Krasińska Joanna , Stawerska Renata , Lewiński Andrzej

Introduction: The increasing prevalence of obesity in children and adolescents is contributing to the increasing diagnosis of insulin resistance (IR) in these individuals. However, it remains a worldwide problem to establish diagnostic criteria of IR in the developmental-age population. IRIHOMA and the IRIBelfiore are the well-known indices used in clinical practice. The aim of the study was to compare the usefulness of IRIBelfiore and IRIHOMA in the early dia...

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hrp0097p1-448 | Fat, Metabolism and Obesity | ESPE2023

The Association between Vitamin D deficiency and Hepatosteatosis in Obese Children and Adolescents. (Underreview in Hormone Research Journal- HRP-2023-1-19)

Anil Korkmaz Huseyin , Bhushan Arya Ved , Barisik Vatan , Atila Dincer , Coskunol Fulya , Alci Serra , Ertug Cekdemir Yasin , Torlak Derun , Ozkan Behzat

Objective: To compare the serum 25-hydroxy Vitamin D [25(OH)D] concentrations in children and adolescents with obesity with and without hepatosteatosis, and investigate the relationship between serum 25(OH)D concentrations and severity of hepatosteatosis. We also aimed to assess the effect of vitamin D treatment after 6 months on hepatosteatosis and liver biochemistry.Methods: One hundred thirty-three obese patients with...

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hrp0097p1-449 | Fat, Metabolism and Obesity | ESPE2023

Body composition following initiation of daily glucocorticoid in Duchenne Muscular Dystrophy: Identifying the timing of increase of fat mass to introduce intensive weight management strategies

McQuillan Erin , Dunne Jennifer , Mochrie Rachel , Horrocks Iain , Joseph Shuko , Choong Wong Sze

Background: Glucocorticoid (GC) therapy is standard of care of management of Duchenne Muscular Dystrophy (DMD) but its use is associated with a range of side-effects. Weight gain leading to significant obesity is common in GC treated boys. There are limited studies evaluating body composition in DMD following initiation of GC, and the timing of increase in fat mass is not known.Aim(s): To evaluate changes in growth param...

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hrp0097p1-450 | Fat, Metabolism and Obesity | ESPE2023

Longitudinal analysis of CCDC3 methylation in placenta and peripheral blood in school-age children: association with gestational obesity and childhood obesity

Niubó-Pallàs Maria , Gómez-Vilarrubla Ariadna , Mas-Parés Berta , Carreras-Badosa Gemma , Bonmatí Alexandra , Ortega Martínez Paz , Martínez-Calcerrada Jose-María , de Zegher Francis , Ibañez Lourdes , López-Bermejo Abel , Bassols Judit

Introduction: The CCDC3 gene encodes for a protein expressed in endothelial cells and adipose tissue. Insulin increases its expression and, in turn, CCDC3 positively regulates adipogenesis and lipid accumulation. CCDC3 expression is increased in visceral adipose tissue from subjects with obesity. Gestational obesity can modify the metabolic programming in the offspring through epigenetic mechanisms. However, it is unknown whether the...

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hrp0097p1-451 | Fat, Metabolism and Obesity | ESPE2023

Diagnostic Journey with an 80-gene Panel in Non-syndromic Early-Onset Severe Obesity: Association of Outcomes with Metabolic Status and Hyperphagia

Tercan Ummahan , Yildiz Melek , Dilruba Aslanger Ayca , Derya Kardelen Al Asli , Poyrazoglu Sükran , Bas Fİrdevs , Darendeliler Feyza

Background: Monogenic defects are among the significant causes of early-onset non-syndromic severe obesity in childhood. Identifying the genetic cause of obesity can guide for treatment. The aim of our study is to investigate the clinical and biochemical features of patients with early-onset severe obesity and evaluate the underlying molecular diagnosis.Materials and Methods: A total of 39 patients (M/F: 22/17) with non-...

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hrp0097p1-452 | Fat, Metabolism and Obesity | ESPE2023

Single center experience on using Liraglutide in adolescents with obesity +/- Type 2 diabetes

Dauleh Hajar , Pasha Maheen , Gad Hoda , Harris Basma , Khalifa Amal , Petroveski Goran , Afyoni Houda , Shehzad Saira , Chirayath Shiga , Mohamadsalih Ghassan , Mohammed Shaymaa , Malik Rayaz , Hussain Khalid

Background: Childhood obesity is recognized as a chronic illness with limited therapeutic options. Addressing this condition through lifestyle interventions has proven to be challenging, particularly for adolescents, with only minimal outcomes observed. The use of GLP-1 agonists (such as Liraglutide) for reducing body weight in pediatric patients has yielded conflicting results. To date, no studies conducted in the Middle East have reported on the outcomes of ...

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hrp0097p1-453 | Fat, Metabolism and Obesity | ESPE2023

Echocardiographic assessment of periaortic fat thickness and its relationship to cardiovascular risk factors in children with simple obesity

Abdelghaffar Shereen , M. Fattouh Aya , Ali Mohamed Ola , Arafa Noha

Key words: Childhood, Obesity, Periaortic fat thickness, Echocardiography, Cardiovascular risk.Aim: To assess the periaortic fat thickness (PAFT) by echocardiograpy in a cohort of children with simple obesity and to evaluate its relationship to clinical and metabolic cardiovascular risk factors.Methods: Fifty children and adolescents with simple obesity and 25 healthy sex and age m...

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hrp0097p1-454 | Fat, Metabolism and Obesity | ESPE2023

Identification of Distinct Metabolic Profiles in Childhood Hypercholesterolemia Using Metabolomics Analysis

Gu Pei-Shin , Su Kuan-Wen , Chiu Chih-Yung , Lo Fu-Sung

Background: Despite the importance of hypercholesterolemia in children, it is overlooked, and there are currently few metabolomics-based approaches available to understand its molecular mechanisms.Methods: Children from a birth cohort had their cholesterol levels measured with the aim of identifying the metabolites for the molecular biological pathways of childhood hypercholesterolemia. One hundred and twenty-five childr...

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hrp0097p1-455 | Fat, Metabolism and Obesity | ESPE2023

Non-Syndromic Monogenic Obesity and Psychiatric Disorders

Arslan Emrullah , Inan Kaleli Ipek , Ozalp Kızılay Deniz , Ata Aysun , Aykut Ayca , Jalilova Arzu , Goksen Damla , Ozbaran Burcu , Darcan Sukran

Introduction: Childhood obesity has been associated with many physical and mental health problems.A significant relationship has been reported between psychiatric disorders, especially attention deficit hyperactivity disorder(ADHD) in obese patients due to the melanocortin 4 receptor(MC4R) gene variant, and it has been claimed that these two conditions may share common molecular pathways. However, studies on this subject are quite insufficient.<p class="ab...

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hrp0097p1-456 | Fat, Metabolism and Obesity | ESPE2023

Higher levels of liver enzymes are associated with increased left ventricular mass in apparently healthy children. Potential role of HMW-adiponectin and epicardial fat

Vasileva Fidanka , Carreras-Badosa Gemma , Serrano-Ferrer Juan , Mas-Parés Berta , Gómez-Villarubla Ariadna , Osiniri-Kippes Inés , Bassols Judit , Prats-Puig Anna , López-Bermejo Abel

Introduction: An increase in liver enzymes predicts cardiac hypertrophy secondary to increased left ventricular mass in patients with cardiovascular disease. The mechanisms involved include decreased adiponectin concentration and increased epicardial fat in these subjects. We hypothesized that associations between these parameters would also be readily apparent in otherwise healthy children.Objectives: Our objective was ...

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hrp0097p1-457 | Fat, Metabolism and Obesity | ESPE2023

PCSK1 Heterozygous Gene Polymorphisms are Associated with Early Onset Morbid Childhood Class III Obesity Across Diverse Ethnic Groups.

Maharaj Vedatta , Bhangoo Amrit , Volcotrub Egor , Khurana Divya , Javier Aisenberg Javier , Ten Svetlana

Aim of the study: Correlate genetic data of patients heterozygous of PCSK1 gene variations with the clinical phenotype.Introduction: Heterozygous variants of the PCSK1 gene have been described in cases of early onset of morbid obesity in childhood. This gene encodes prohormone convertase 1/3 enzyme, a serine endoprotease expressed in neuroendocrine cells that converts inactive prohormones into functional hormones importa...

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hrp0097p1-458 | Fat, Metabolism and Obesity | ESPE2023

Dietary and physical activity habits in children and adolescents in Greece

Petrou Ioulia , Ioannou Georgia , Manou Maria , Papadopoulou Marina , Tragomalou Athanasia , Kassari Penio , Charmandari Evangelia

Introduction: Obesity in childhood and adolescence is a major problem with many adverse consequences in public health due to its increasing prevalence, as well as the burden on the health system. Recently, the need to find effective intervention and prevention strategies for the management of obesity has led to the development of e-health technologies, which record behavioral data objectively and correlate them with factors that increase body mass index (BMI)....

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hrp0097p1-459 | Fat, Metabolism and Obesity | ESPE2023

Digestive manifestations are frequent in iPPSD/Pseudohypoparathyroidism

Goy Berenice , Rothenbuhler Anya , Audrain Christelle , Berkenou Jugurtha , Linglart Agnes , Dubern Beatrice

Introduction: Pseudohypoparathyroidism (hereafter named iPPSD for inactivating PTH/PTHrP Disorder) is a rare disease characterized by hormonal resistance including PTH, subcutaneous ossifications, short stature, brachymetacarpy and early onset obesity. iPPSD type 2 and 3 are caused by genetic or epigenetic variations in the GNAS gene or its promoters. Although uncommon features have been identified such as severe asthma or sleep apnea, digestive manifestations...

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hrp0097p1-460 | Fat, Metabolism and Obesity | ESPE2023

Improvement of Depressive and Anxiety Symptoms in Children and Adolescents with Overweight and Obesity Following Implementation of a Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention Program

Vourdoumpa Aikaterini , Paltoglou George , Kassari Penio , Manou Maria , Papadopoulou Marina , Kolaitis Gerasimos , Charmandari Evangelia

Introduction: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems. Psychosocial problems noted in youngsters with excess adiposity persist for a long time. The aim of our study was to assess mental health symptoms in overweight and obese children and adolescents before and a...

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hrp0097p1-461 | Fat, Metabolism and Obesity | ESPE2023

Study on the correlation of metabolic syndrome with sex hormone binding protein and testosterone in obese boys

Yang Yu , Liang Yiwei

Objective: To explore the correlation of sex hormone-binding globulin (SHBG) and Total Testosterone (TT) with the development of Metabolic syndrome (MetS) in obese boys. To explore the relationship between components of MetS and TT levels in boys.Methods: A total of 439 boys aged 6-18 years old from April 2020 to February 2023, include boys who visited the Department of Endocrinology, Genetics and Metabolism in Jiangxi P...

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hrp0097p1-462 | Fat, Metabolism and Obesity | ESPE2023

Determinants of reduced insulin sensitivity in young adults born from preeclamptic pregnancies

Seppä Satu , Tenhola Sirpa , Jääskeläinen Jarmo , Voutilainen Raimo

Background: Maternal preeclampsia has been associated with increased risk for later metabolic disturbances in the offspring.Objective: We investigated whether maternal preeclampsia influences insulin sensitivity (IS) and low-grade inflammation in young adulthood and whether unfavourable metabolic features in childhood predict low IS at 20 years of age.Methods: Forty-seven 20-year-o...

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hrp0097p1-463 | Fat, Metabolism and Obesity | ESPE2023

Association between lean mass and metabolic syndrome risk in Korean children and adolescents

Suk Shim Young , Sang Lee Hae , Rim Jeong Hwal , Sub Lim Jung , Soon Hwang Jin

Introduction: Skeletal muscle plays a crucial role in glucose disposal, and studies have shown a positive relationship between muscle mass and insulin sensitivity. However, an elevated lean mass has also been associated with metabolically adverse outcomes. This study aimed to evaluate the association between the risk of metabolic syndrome (MetS) and lean mass using dual-energy X-ray absorptiometry (DXA) in a nationally representative sample from the Korea Nati...

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hrp0097p1-464 | Fat, Metabolism and Obesity | ESPE2023

Occurrence of cardiovascular risk factors in Polish children and adolescents with severe obesity. Preliminary results of the Polish-German study project on severe early-onset obesity

Stępniewska Anna , Szczudlik Ewa , Bik-Multanowski Mirosław , Brandt Stephanie , Flehmig Bertram , Małecka-Tendera Ewa , Mazur Artur , Petriczko Elżbieta , B. Ranke Michael , Zachurzok Agnieszka , Wójcik Małgorzata

It is estimated that 1-5% of children and adolescents in Europe suffer from severe obesity (corresponding to an adult BMI > 40 kg/m2). However, in risk stratification, the occurrence of metabolic complications is more important than BMI itself. The study aimed to assess the occurrence of cardiovascular risk factors in a cohort of children and adolescents with severe obesity.Patients and Methods: The analysis included 140 patients (75 ...

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hrp0097p1-465 | Fat, Metabolism and Obesity | ESPE2023

When a pandemic hits another pandemic: the rising overweight and obesity in children in North Macedonia

Arjeta Raufi , Maneva Konstandina Kuzevska , Konstantinova Marina Krstevska , Naser Durmishi

Key Words: Childhood obesity, Prevalence, Covid-19, N. Macedonia Abstract Childhood obesity is a growing concern and a worldwide pandemic. North Macedonia, a small middle-income country with a population of around 2 million, is among the top 10 countries in Europe with a high prevalence of overweight and obesity. The aim of this study is to observe how the COVID-19 pandemic ...

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hrp0097p1-466 | Fat, Metabolism and Obesity | ESPE2023

The effect of lifestyle intervention on glycaemic variation, quality of life and satiety levels in children and young people with obesity

Apperley Louise , Senniappan Senthil

Introduction: Childhood obesity is associated with pre-diabetes and type 2 diabetes mellitus. The gold standard investigation for these is an oral glucose tolerance test (OGTT). The aim of our study is to investigate glycaemic dysregulation in children and young people (CYP) with obesity using continuous glucose monitoring (CGM) and evaluate the effect of intense lifestyle intervention on various complications.Methods: 3...

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hrp0097p1-467 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of concentrations of homocysteine in obese and overweight adolescents and its correlation with lipid and carbohydrate parameters

Rumińska Małgorzata , Witkowska-Sędek Ewelina , Krajewska Maria , Majcher Anna , Stelmaszczyk-Emmel Anna , Pyrżak Beata

Background: Metabolic and hemodynamic obesity-related disorders are a major risk factor for cardiovascular disease in children with excess body fat mass. Studies in adults suggest that serum homocysteine is a marker of atherosclerosis and is associated with vascular dysfunction. Studies in children are inconclusive. The aim of the study was to evaluate the association between homocysteine concentrations and lipid and carbohydrate metabolism parameters in obese...

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hrp0097p1-468 | Fat, Metabolism and Obesity | ESPE2023

Efficacy of zinc and myo-inositol on weight loss and metabolic features in a pediatric population with obesity

Antoniotti Valentina , Colombo Alice , Mancioppi Valentina , Solito Arianna , Partenope Cristina , Petri Antonella , Rabbone Ivana , Ferrante Daniela , Prodam Flavia , Bellone Simonetta

Pediatric obesity is constantly increasing and exposes to serious cardiovascular and metabolic risks. The first treatment against obesity is lifestyle change. Actually, any intervention seems to be effective on the evolution of this condition, especially in the long term. For this reason, the interest in non-pharmaceutical compounds is growing. Several studies mentioned the use of zinc and inositol as compounds acting on weight loss and insulin resistance. The aim of this stud...

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hrp0097p1-469 | Fat, Metabolism and Obesity | ESPE2023

Compound heterozygous SLC5A2-Mutation leading to familial renal glucosuria in an 11-year-old boy

Habacht Daniela , Zeitlhofer Petra , Hammer Karin , Haas Oskar , Riedl Stefan

Background: The SGLT2 (Sodium-Glucose Cotransporter 2) protein is responsible for the majority of glucose reabsorption in the proximal tubule. Mutations in SLC5A2, encoding SGLT2, have been first described in 2002, leading to familial renal glucosuria (FRG). Herein we describe the clinical course of an 11-year-old boy in whom a compound heterozygous SLC5A2-mutation was detected, who presented with glucosuria and vomiting with a suspected diagnosis of diabetes....

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hrp0097p1-470 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of the Frequency and Time Course of Side Effects Asscociated With Metformin Use In Obese Adolescents As Related to Weight Loss: A Prospective Single-Centre Observational Study

Mısırlı Özdemir Ebru , Dağdeviren Çakır Aydilek , Bilge Özakçe Mehmet , Uçar Ahmet

Background: Metformin is a well-known biguanide approved for treatment of Type2 Diabetes. Metformin is not considered as an anti-obesity drug despite its common off-label use. Currently, there are no data regarding the profile of metformin related gastrointestinal side effects (MRGSE) in obese adolescents.Aim: To identify the frequency and time course of MRGSE in obese adolescents and assess the presence of any associati...

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hrp0097p1-471 | Fat, Metabolism and Obesity | ESPE2023

Life-saving management and therapy in a growth-hormone naive superobese adolescent with Prader-Willi Syndrome: Very low energy diet, GLP-1 analog and nasal oxytocin.

Gürpınar Gözde , Kilci Fatih , Koçyiğit Esra , Hürmüzlü Közler Selen , Küçükkeskin Sema , Huw Jones Jeremy , Donaldson Malcolm , Mine Çizmecioğlu Jones Filiz

Introduction: Prader-Willi Syndrome (PWS) is characterized by severe neonatal hypotonia and feeding difficulty with subsequent hyperphagia, hypogonadism, and short stature. PWS has a prevalence of 1 in 10,000-30,000. Obesity-related complications occur from early childhood onwards. Liraglutide is a glucagon-like peptide-1 (GLP-1) analog that reduces appetite and body weight and improves glycemic control. Scarcity of oxytocin-producing neurons in the hypothalam...

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hrp0097p1-472 | Fat, Metabolism and Obesity | ESPE2023

First Case of Familial Partial Lipodystrophy Type 2 (FPLD2) from Kazakhstan Presenting with Life Threatening Arrhythmias and Dilated Cardiomyopathy

Nurbekova Akmaral , Ten Svetlana , Bhangoo Amrit

Background: Familial partial lipodystrophy type 2 (FPLD2) is a heterogeneous rare disease characterized by selective fat loss, mainly affecting the limbs. It is attributed to LMNA gene, which encodes lamins A and C, structural proteins components of the nuclear lamina. LMNA variants have been previously described with cardiac abnormalities with and without lipodystrophy in FPLD2.Case description: We describe a 1...

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hrp0097p1-473 | Fat, Metabolism and Obesity | ESPE2023

Metabolic Profile of Obese North Macedonian children and adolescents

Krstevska Konstantinova Marina , Kuzevska Maneva Konstandina , Sukarova-Angelovska Elena , Janchevska Aleksandra , Bojadzieva Sonja , Koceva Svetlana , Gjurkova Beti , Tankoska Maja , Raufi Arjeta , Paruleska Elena , Teov Bojan , Beqiri Ardiana

Introduction: Obesity in children and adolescents is increasing, and represents a global concern regarding future health related consequences. It has been classified as a disease that affects a large number of individuals.Materials and Methods: We have recruited 119 obese children and adolescents from our outpatient Pediatric Endocrine Clinic for metabolic evaluation between the year 2018-2022. There was a 2year disconti...

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hrp0097p1-474 | Fat, Metabolism and Obesity | ESPE2023

Identifying MAFLD and its metabolic risk factors in Polish children and adolescents with severe obesity. Preliminary results of the Polish-German study project on severe early-onset obesity.

Mierzwa Magdalena , Malczyk Żaneta , Bik-Multanowski Mirosław , Brandt Stephanie , Flehmig Bertram , Małecka- Tendera Ewa , Mazur Artur , Petriczko Elżbieta , B. Ranke Michael , Wabitsch Martin , Wójcik Małgorzata , Zachurzok

Agnieszka

Background: Fatty liver disease in children and adolescents is the most common cause of chronic liver disease in many countries. Criteria for a diagnosis of pediatric metabolic associated fatty liver disease (MAFLD) are based on hepatic steatosis in ultrasound, blood biomarkers or liver biopsy in association with one of the three criteria: excess adiposity (overweight, obesity or abdominal obesity), prediabetes or type 2 diabetes, or evidence of metabolic dysr...

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hrp0097p1-475 | Fat, Metabolism and Obesity | ESPE2023

A girl with ROHHAD syndrome – a rare cause of rapid-onset obesity and hypothalamic dysfunction

Galcheva Sonya , Hachmeriyan Mari , Krumova Darina , Georgiev Radoslav , Dancheva Zhivka , Begemann Matthias , Eggermann Thomas , Iotova Violeta

Background: The rapid-onset obesity with hypoventilation, hypothalamic, autonomic dysregulation (ROHHAD) is a long-known rare condition with a high morbidity and mortality rate, and still unknown etiology.Objective: We aim to present the clinical findings and treatment in a patient with ROHHAD syndrome.Case presentation: A 4-year-old girl had normal development until March 2022 whe...

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hrp0097p1-476 | Fat, Metabolism and Obesity | ESPE2023

Complications of excess weight (CEW) seen in tier-3 paediatric weight management services: A two-centre experience

Apperley Louise , Hawton Katherine , Parkinson Jennifer , Owens Meghan , Semple Claire , Fitzgerald Amy , Easter Shelley , Clark Kate , Lund Kim , Clarke Ellie , Giri Dinesh , Senniappan Senthil , Hamilton-Shield Julian

Background: Children and young people living with severe obesity experience a range of complications of excess weight (CEW), however the prevalence of complications is not well defined. We have evaluated baseline clinical characteristics and CEW of patients seen in two multi-disciplinary tier-3 paediatric weight management services in different regions of the UK.Methods: All new patients (n=185) aged 2-17 years ...

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ESPE Abstracts

61st Annual ESPE (ESPE 2023)

BiosciAbstracts