Previous issue | Volume 97 | ESPE2023

61st Annual ESPE (ESPE 2023)

The Hague, Netherlands
21 Sep 2023 - 23 Sep 2023

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The 61st ESPE Annual Meeting will now be taking place in The Hague, The Netherlands

Poster Category 1

Fetal, Neonatal Endocrinology and Metabolism

hrp0097p1-84 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Impact of bariatric surgery on newborn growth parameters

Nicolas Georges , Aoun Rayen

Keywords: Bariatric surgery, Pregnancy, Maternal obesity, Small for gestational age, fetal growth, Nutritional deficiencies.Background: Maternal obesity is known to have many detrimental effects on pregnancy. Bariatric surgery represents the most efficient therapy for severe obesity. Although it is known to positively impact many pregnancy outcomes, bariatric surgery can disturb fetal growth due to nutritional deficienci...

hrp0097p1-85 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Associations of eating behavior and metabolic status in young children and variants of energy metabolism genes

Prylutskaya Veranika , Pavlovich Tatyana , Solntsava Anzhalika

Objectives: The aim of the study was to evaluate the associations of metabolic status and eating behavior (EB) in young children and variants of energy metabolism genes.Materials and Methods: A longitudinal study of 106 children in the dynamics of the first 2 years of life was carried out. Groups of children were identified taking into account BW at birth (large-weight by gestation (n=50), underweight by gestati...

hrp0097p1-86 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Measurements of Growth Hormone using dried blood spots in preterm neonates: reference values and longitudinal evaluation.

Federico Giacchetti , Orsenigo Chiara , Vizzari Giulia , Tarricone Silvia , Vantaggiato Chiara , Rodari Giulia , Napolitano Filomena , Sangiorgio Andrea , Morniroli Daniela , Colombo Lorenzo , Profka Eriselda , Collini Valentina , Risio Alessandro , Lorella Giannì Maria , Arosio Maura , Mantovani Giovanna , Mosca Fabio , Ceriotti Ferruccio , Vidali Matteo , Giavoli Claudia

Background and aim: Congenital growth hormone deficiency (cGHD) is a rare but life-threatening condition whose diagnosis is challenging in the absence of reliable reference values, both in healthy neonates and in preterm ones. We recently estimated GH reference interval in 1036 healthy, at-term newborns (HN) form dried blood spot samples using a previously validated analytical method.Aim: of this study is to provide valu...

hrp0097p1-87 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

A novel CACNA1D mutation leading to severe diazoxide unresponsive CHI

Melikyan Maria , Gubaeva Diliara , Novokreschennih Evgeniya

Introduction: Approximately 25% of congenital hyperinsulinism (CHI) patients are unresponsive to medical therapy. These cases are usually associated with inactivating ABCC8/KCNJ11 genes mutations or rarely with dominant GCK variants. Activating dominant mutations in the CACNA1D gene were recently found to cause mild form of CHI, muscle hypotonia and autistic features.Objectives: Herein we descr...

hrp0097p1-88 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

The variable outcome of childhood growth in congenital hyperinsulinism

Väätänen Oona , Saari Antti , Huopio Hanna , M.E. Männistö Jonna

Background: There is limited knowledge about the natural history of growth in patients with congenital hyperinsulinism (CHI). The disease itself, as well as its treatment methods with common long-term sequalae in terms of pancreatic endocrine and exocrine dysfunction have the potential to affect growth. We investigated longitudinal height growth of CHI patients in a large Finnish cohort.Materials and methods: In this cro...

hrp0097p1-89 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Maternal, placental and fetal IGF-1/IGFBP in Diabetic pregnancies and their effect on fetal/infantile growth

Soliman Ashraf Alaaraj Nada , Ahmed Shayma , Alyafei Fawzia , Soliman Ashraf

Introduction: In diabetic pregnancies, data about the interaction between maternal, placental, and fetal IGF1/IGFBP in relation to newborn size is not clear,Aim: To review research papers published in Pubmed, Google scholar, Research gate, and Scopus in the past 20 years on the relation between placental IGF1/IGFBP-1 and fetal/infantile/childhood growth in pregnancies associated with maternal diabetes.<p class="abste...

hrp0097p1-90 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Low-Dose Diazoxide Therapy in Hyperinsulinaemic Hypoglycaemia

Yi-Lin Ng Amy , Agarwal Pankaj , Vijayan Roopa , B Arya Ved , R Kapoor Ritika , Shah Pratik

Background: Diazoxide therapy is used as first line treatment in hyperinsulinaemic hypoglycaemia (HH). Apart from a single study reporting efficacy of low dose diazoxide in small for gestational age (SGA) infants, diazoxide has been reported to be used in doses of 5-20 mg/kg/day [1].Objective: To report the outcomes of infants with HH responsive to low dose diazoxide (≤5mg/kg/day).Method...

hrp0097p1-91 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Short- and Long-term Outcomes of Diazoxide Unresponsive Infants with Diffuse Hyperinsulinism

Rafferty Deborah , Truong Lisa , Nedrelow Jonathan , Uffman Chip , Pugenent Burton , Sanchez Irene , Thornton Paul

Background: Severe diazoxide unresponsive hyperinsulinism (DUHI) is most often caused by autosomal recessive variants in the KATP channel genes. Because of the limited medical treatments available, many patients are treated with 98% pancreatectomy. This results in a high rate of diabetes by the age of 15 years. Many centers now try to avoid surgery to prevent the inevitable transition to post-surgical diabetes.Objectives:</strong...

hrp0097p1-92 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Relationship between birth body weight< centile (sga) and insulin-like growth factor binding protein-3: relevance of birth chest circumference / birth body weight ratio independently of birth gestational age, insulin-like growth factor binding protein-1 and -2 in the not-life threatened newborn

Terzi Cesare , Virdis Raffaele , Magnani Cristiana , Tridenti Gabriele , Cerioli Andrea , Riani Marco , Garavelli Lidia , Luigi De Angelis Gian , Bernasconi Sergio , F. Blum Werner , Banchini Giacomo

Birth chest circumference(CC) shows often, like birth gestational age(GA), tight direct relations to birth body weight(BW). However distinct connections of hypoxia/undernutrition with different body structures might be suspected based on brain-, heart- and adrenal-sparing following intrauterine growth restriction and, postnatally, on higher chest size for body mass observed at high altitude. Growth retarded fetuses gestated by hypoxic pregnant animals may present increments of...

hrp0097p1-93 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Incidence and etiology of congenital hyperinsulinism in Slovakia

Lobotkova Denisa , Minova Martina , Ferenczova Juliana , Dankovcikova Adriana , Sevecova Maria , Tarnokova Simona , Huckova Miroslava , Skopkova Martina , Gasperikova Daniela , Stanik Juraj

Background: Congenital hyperinsulinism (CHI) is the most common cause of the persistent hypoglycemia in children and occurs in approximately 1 in 50,000 live births. Genetic testing provides information on the pancreatic histological subtype (i.e. focal vs diffuse) and determines further management and prognosis of the patients. At least 11 known monogenic forms and several syndromes have been associated with CHI. Mutations in ABCC8 and KCNJ11 genes coding pot...

hrp0097p1-94 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Thyroid function in small for gestational age and appropriate for gestational age preterm infants admited to the NICU at Notre Dame Des Secours - University Medical Center

Nicolas Georges , Achkar Joy

Keywords: Preterm newborn, Small for gestational age, Thyroid hormones, Thyroid-stimulating hormone, Thyroid dysfunctions, Thyroid function tests.Background: A common cause of neurodevelopmental impairment in children is congenital hypothyroidism, but can be preventable with adequate screening and proper management. Preterm newborns are more likely to have thyroid dysfunction, with small for gestational age (SGA) being a...

hrp0097p1-277 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Severe neonatal hypoglycemia ≤30 mg/dl is associated with adverse neurodevelopment in mid-childhood

Roeper Marcia , Hoermann Henrike , Koerner Lisa , Mayatepek Ertan , Kummer Sebastian , Meissner Thomas

Introduction: Neonatal hypoglycemia (NH) affects about 15% of all neonates and about 50% of neonates born with risk factors, including maternal diabetes, large- or small for gestational age, or prematurity. Although it is known that hypoglycemia in congenital hyperinsulinism can lead to brain injury, it is still not clear to what extent transitional NH is tolerated during the first days of life without brain damage. Thus, treatment thresholds and management st...

hrp0097p1-278 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Exploration of O-link protein biomarkers in children born after IUGR and early impaired developmental changes in heart function

Änghagen Olov , Rudholm Feldreich Tobias , Ärnlöv Johan , Bang Peter

We recently assessed systolic heart function in children from IUGR and normal control pregnancies and reported early developmental impairment of left ventricular longitudinal strain – a sensitive echocardiographic measure – during the first 3 months of life in IUGR children. In accordance with previous studies, this suggest that the increased cardiovascular risk later in life imposed by IUGR/SGA may, at least to some extent, be primary and not entirely secondary to...

hrp0097p1-279 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

A Year-Long, National Trial of Prospective CGM Use in Families with Hyperinsulinism

Worth Chris , Worthington Sarah , Auckburally Sameera , Ahmad Sumera , O'Shea Elaine , Ferrera-Cook Chris , F Betz Stephen , Salomon-Estebanez Maria , Banerjee Indraneel

Introduction: Congenital hyperinsulinism (CHI) is the commonest cause of severe hypoglycaemia in early childhood but glycaemic characterisation remains scarce. Continuous glucose monitoring (CGM) offers a deep understanding of glycaemic control to understand disease burden, individualise patient care and inform therapeutic trials in CHI. Preliminary studies suggest inadequate accuracy and no efficacy of standalone CGM to reduce hypoglycaemia. Provision is hist...

hrp0097p1-280 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

The Metabolism of 11-Oxy Androgens by Fetal CYP3A7 and CYP3A4 is Less Efficient Compared to Classical Androgens

du Toit Therina , E Flück Christa , V Pandey Amit , Groessl Michael

Steroidogenic enzyme expression in the fetal adrenal and the placenta hints at the production and metabolism of adrenal-derived 11-oxy androgens (11OxyAs) in the fetal-placental unit. Thus, 11OxyAs are present in placental tissue, fetal cord blood and neonatal serum, and could have a particular role during fetal development. The metabolism of the 11OxyAs in the fetal unit, therefore, presents as a focal point of investigation. Adrenal androgens are primarily metabolized by the...

hrp0097p1-281 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Steroid secretion and morphological aspects of fetal adrenal before/after freezing/thawing and 14 days in organotypic culture

Renault Lucie , Labrune Elsa , Giscard d'Estaing Sandrine , Bideault Valeska , Schneider Grégoire , Mure Pierre-Yves , Lalli Enzo , Doghman-Bouguerra Mabrouka , Dijoud Frédérique , Lejeune Hervé , Plotton Ingrid

Introduction: The human fetal adrenals (HFA) produce high levels of steroids. The gland is distinguishable from the 7th gestational week and can be separated in two zones: the fetal zone in the center which correspond of 80 % of the gland and the definitive zone in the periphery. At this time of the development, neural crest cells are reaching the adrenal primordium, producing catecholamines. A third zone, the transitional zone appears later in the early 2nd t...

hrp0097p1-282 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Measurement of fetal subcutaneous fat in the diagnosis of fetal macrosomia in pregnancies with diabetes mellitus

Victor Svetlana , Prylutskaya Veranika , Kurlovich Ivan , Vashchilina Tatyana

Background and aim: Pregnancy with diabetes mellitus is associated with obstetric and neonatal complications, including the development of fetal macrosomia. Fetal macrosomia of diabetic origin is characterized by a disproportionate distribution of subcutaneous fat with predominant localization in the upper half of the fetus body. The cause of excess fetal growth is maternal hyperglycemia, regardless of the type of diabetes in the mother. The aim of study was t...

hrp0097p1-283 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Developing a Collaborative Research Network to Accelerate the Understanding and Treatment of the Rare Disease Congenital Hyperinsulinism

Pasquini Pasquini Tai , Raskin Julie , De León-Crutchlow Diva , Banerjee Indi , Christesen Henrik , Conwell Louise , Dastamani Antonia , Flanagan Sarah , Gillis David , Kalish Jennifer , Lord Katherine , Stanley Charles , Zangen David , Thornton Paul

Background: Congenital Hyperinsulinism International (CHI) is an international non-profit organization focused on improving the lives of patients and families living with hyperinsulinism (HI). Despite many advances in the care of patients with HI, long term neurologic outcomes have not significantly improved, highlighting the need for CHI’s goals for robust and rapidly translatable research. We describe the development of a collaborative research network...

hrp0097p1-284 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Neonatal hypoglycemia at one and four hours of life: incidence and associated factors

Nicolas Georges , Khalil Rita

Key words: neonates, hypoglycemia, size for gestational age, gender, mode of delivery.Introduction: Neonatal hypoglycemia is one of the most common treatable metabolic disorders. Universal newborn screening for hypoglycemia is primordial in detecting persistent hypoglycemia and asymptomatic episodes in order to save neonates from adverse neurological outcomes and brain injury.Objectives:</s...

hrp0097p1-285 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Severe Neonatal Donohue Syndrome: Extreme Hyperinsulinemia, Progressive Hypertrophic Cardiomyopathy (HCM) and Failure to Thrive

Lämmer Constanze , Langer Johanna , de Potzolli Brigitte , Liebl Stefanie , M.K. Völkl Thomas

Introduction: Donohue syndrome (DS) is presenting as the most severe form of insulin resistance. Most of the patients are dying within the first two years of life. As potential treatment has been described the administration of rhIGF1 (Mecasermin) to stimulate the pathway of insulin-like action. An improved metabolic control was reported with continuous subcutaneous administration of rhIGF1 instead of twice daily injections [Plamper 2018].<p class="abstext...

hrp0097p1-286 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Aetiology and Outcome of Hypoglycaemia in Young Children

Yean Chai Xin , Guftar Shaikh M. , D. McNeilly Jane

Background: Hypoglycaemia is one of the most common presenting complaints at paediatric emergency department. There are many distinct causes of hypoglycaemia, ranging from nutritional insufficiency, infectious origins, to metabolic disorders. A thorough investigation can help differentiate the cause of hypoglycaemia, with subsequent tailored management. All patients with hypoglycaemia should have a full clinical assessment and together with a hypoglycaemia scr...

hrp0097p1-287 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Mutations in exon 28 of ABCC8 gene in Egyptian patients with congenital hyperinsulinism

Abdelghaffar Shereen , Madani Hanan , Ashour Mohammed , Ahmed Yomna , Abdou Maryz

Background: Congenital hyperinsulinism in infancy (CHI) is the most frequent cause of persistent hypoglycemia in infants. The most common and severe form of monogenic CHI is caused by inactivating mutations in ABCC8 and KCNJ11 genes located on chromosome 11p15.1. On the ABCC8 gene; previous studies have shown that mutations were reported to be mostly localized in exon 28. There is no sufficient research in Egyptian population about different mutations in conge...

hrp0097p1-477 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Newborn screening for Congenital adrenal hyperplasia in Pakistan; Pioneering the way forward

Memon Fozia , Ahmed Sibtain , Arif Muzna , Haider Maryam , Kirmani Salman , Nuzhat Humayun Khadija

Objective: This study aims to evaluate the effectiveness and efficiency of weight-based threshold levels for 17-hydroxyprogesterone (17-OHP) in screening newborns for 21 hydroxylases deficiency-congenital adrenal hyperplasia (CAH)Design: In April 2021 CAH screening was incorporated into the ongoing newborn screening program at aga khan university Hospital Karachi Pakistan,17OHp was assayed through Spectro fluorometry of ...

hrp0097p1-478 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Whole-exome sequencing results in patients with congenital hyperinsulinism.

Melikyan Maria , Gubaeva Diliara , Bolmasova Anna , Kolodkina Anna , Tiulpakov Anatoly , Bogdanov Viktor , Peterkova Valentina

Background: Congenital hyperinsulinism (CHI) is a heterogeneous group of disorders, characterized by hypoglycemia due to inappropriate insulin secretion. Despite huge progress in understanding the pathophysiology of CHI, its etiology remains unknown in about 30% of cases.Aim: To perform whole-exome sequencing in patients with CHI.Results: A total of 314 patients with congenital hyp...

hrp0097p1-479 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Early-life exposure to phthalates and minipuberty: is there any relationship?

Lucaccioni Laura , Palandri Lucia , Trevisani Viola , Righi Beatrice , Calandra Bonaura Filippo , Predieri Barbara , Righi Elena , Iughetti Lorenzo

Background: Nowadays, the role of minipuberty in influencing pubertal development is well documented. Phthalates are ubiquitous environmental contaminants and endocrine-disrupting chemicals (EDCs) with reproductive toxic effect. Aim of this study is to assess phthalate exposure within the first months of life in a cohort of healthy term infants and their mothers and the possible relationship with minipuberty.Methods: Sin...

hrp0097p1-480 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Grb10a Knockdown in Early Life Permanently Alters Growth, Cardiometabolic Phenotype, and the Co-ordination of the Whole Transcriptome in Zebrafish

Evans Bridget , Garner Terence , De Leonibus Chiara , Wearing Oliver , Shiels Holly , Hurlstone Adam , Clayton Peter , Stevens Adam

The ‘Developmental Origins of Health and Disease’ (DOHaD) hypothesis encapsulates the relationship between pre- and perinatal exposures causing altered growth and the development of later life disease. Mediators of this relationship have not been fully defined. We have used zebrafish [ZF] (Danio rerio) as a potential model for DOHaD, modifying expression of grb10a, an adapter protein that interacts with the insulin and IGF receptors, to act as a negative r...

hrp0097p1-481 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Treatment of Transient Hypothyroxinaemia Of Prematurity may improve premature newborns’ neurodevelopment. NEOTHYR, a multicentered retrospective cohort study about 373 subjects.

Bardet Angélique , Vincent Marine , Bretones Patricia

Background: Transient hypothyroxinaemia of prematurity (THOP), defined as low levels of FT4 without the expected TSH surge, may concern up to 50% of infants born <30 weeks’ gestational age. Most studies showed a link between THOP and impaired neurodevelopment, as shown in the review of Eerdekens. Data about the benefit of supplementation are scarce, with few randomised trials and inconclusive results. To date, there are no clear recommendations regard...

hrp0097p1-482 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Human milk short-chain fatty acids promote early myelination in a 2D human co-culture of oligodendrocytes and cortical neurons.

Elke Chie Stefanie , Szentpetery Zsofia , Natalucci Giancarlo , Consolata Miletta Maria

Background: Human milk is considered the most advantageous source of nourishment for infants. Although there is a growing body of evidence showing that human milk feeding fosters early neurodevelopment, the underlying process is still not completely known. Indeed, clinical and animal research has linked human milk to enhanced myelination in the infant's central nervous system, however, access to human oligodendrocytes and neurons in the early stages of develop...

hrp0097p1-483 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Incidence of Perinatal Stress Hyperinsulinism Requiring Diazoxide Treatment in Newborn Infants

Rafferty Deborah , Truong Lisa , Nedrelow J , Thornton Paul

Background: The incidence of perinatal stress hyperinsulinism (PSHI) requiring diazoxide treatment is estimated to be 1:12,000 (Hoe et al., 2006). Diazoxide is used to treat PSHI, but it has been shown to have adverse effects including pulmonary hypertension. Gray et al, reported that of 1.25 million infants admitted to NICUs for hypoglycemia over a period of 18 years, only 1066 received diazoxide suggesting 1:1172 babies had HI however 92% o...

hrp0097p1-484 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Relationships between birth body weight< centile (SGA) and insulin-like growth factor-ii / insulin-like growth factor binding protein-3 ratio in the not-life threatened newborn: relevance of birth chest circumference / birth body weight ratio and oxygen supplementation

Terzi Cesare , F. Blum Werner , Magnani Cristiana , Tridenti Gabriele , Cerioli Andrea , Riani Marco , Chesi Elena , Luigi De Angelis Gian , Bernasconi Sergio , Virdis Raffaele , Banchini Giacomo

Direct relationships of estimated birth brain weight(BRW) to birth body weight (BW) ratios (BBR) and of BW< centile for GA(SGA) with blood serum Insulin-like Growth Factor-II(IG2) to blood serum Insulin-like Growth Factor Binding Protein-3 (IB3) ratios (IG2/IB3R), and inverse relations between BW-SDS and birth chest circumference(CC) / BW ratio (i.e., CC through BW; CC/BWR) have been detected by our group in the human newborn(NWB). We evaluated the possibility that CC...

hrp0097p1-485 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

A case of a newborn diagnosed with CMAMMA suspected of primary immunodeficiency

Oh Arum , Han Heon-Seok

Background and Aims: Combined malonic and methylmalonic aciduria (CMAMMA) is a rare genetic disorder that affects the body's ability to break down certain proteins and fats. It is caused by mutations in the ACSF3 gene, which provides instructions for making an enzyme involved in the metabolism of fatty acids. As a result of the enzyme deficiency, individuals with CMAMMA experience an accumulation of malonic and methylmalonic acids in their blood and urine...

hrp0097p1-486 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Severe hypercalcemia due to subcutaneous fat necrosis despite minimal skin lesions in a newborn: a case report

Berkenbosch Lizanne , Straetemans Saartje

Introduction: Subcutaneous fat necrosis of the newborn (SCFN) is a self-limiting panniculitis which can develop in the first weeks of life. The disorder is characterized by firm, red or purple subcutaneous nodules and plaques on the trunk, buttocks, cheeks, and extremities and is associated with perinatal stress. SCFN may lead to hypoglycemia, anemia, thrombocytopenia, hypertriglyceridemia and hypercalcemia. The proposed mechanism for the hypercalcemia is extr...

hrp0097p1-487 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

The Association of Maternal Pre-pregnancy BMI and Gestational Weight Gain on the Course of Pregnancy and Some Neonatal Parameters

Nicolas Georges , Rouhana Saly

Keywords: Pre-pregnancy BMI, gestational weight gain, pregnancy outcomes, neonatal outcomes.Background: Overweight and obesity epidemic is still expanding, and it is affecting women of childbearing age. Multiple studies have shown unmatched results concerning the effect of Body Mass Index (BMI) besides gestational weight gain (GWG) on pregnancy and neonatal outcomes.Objectives: Thi...

hrp0097p1-488 | Fetal, Neonatal Endocrinology and Metabolism | ESPE2023

Characteristics of the neonatal period in children with Prader-Willi syndrome

Prylutskaya Veranika , Trebka Ekaterina , Solntsava Anzhalika , Naumchik Irina , Demidovich Tatjana

Background and aim: Prader-Willi Syndrome (PWS) is a rare disease with various clinical signs in different age periods. Early diagnosis has a proven benefit in PWS, allows for timely diet therapy and prevention of obesity, early administration of growth hormone. The purpose of the study is to analyze the features of neonatal adaptation in children with PWS, to evaluate the diagnostic efficacy in the dynamics of the analyzed period.<stron...